Vet Med - Czech, 2006, 51(1):35-43 | DOI: 10.17221/5515-VETMED

Plasma insulin-like growth factor-1 concentration in dogs with chronic enteropathies

A.C. Spichiger1, K. Allenspach2, Y. Zbinden1, M.G. Doherr2, S. Hiss3, J.W. Blum1, S.N. Sauter1
1 Division of Nutrition and Physiology, Institute of Animal Genetics, Nutrition and Housing,
2 Department of Clinical Veterinary Medicine, University of Bern, Bern, Switzerland
3 Institute of Animal Science, Physiology and Hygiene, University of Bonn, Bonn, Germany

Plasma concentrations of insulin-like growth factor (IGF)-1 were examined in dogs suffering from food-responsive diarrhea (group FRD) or inflammatory bowel disease (group IBD) before and after treatment and compared with IGF-1 values in healthy dogs (group C). Blood of 76 dogs was sampled (FRDbefore treatment, n = 23; IBD before treatment, n = 11; C, n = 42) and after treatment (FRD, n = 15; IBD, n= 8) with a hypoallergenic diet combined with (group IBD) or without prednisolone (group FRD). A clinical score (Canine IBD Activity Index = CIBDAI) was applied to judge the health status in all dogs. Plasma concentration of IGF-1, of total protein, albumin, glucose, urea, non-esterified fatty acids (NEFA), and of the acute phase protein haptoglobin was measured in all dogs. The CIBDAI scores decreased during the treatment period in FRD and IBD (P < 0.05). IGF-1 concentrations were positively correlated with body weight (BW) (rsp = 0.65, P < 0.001) and values of IGF-1 were therefore normalized with BW. IGF-1/BW ratios were lower in FRD and IBD before treatment than in C (P < 0.01). IGF-1/BW ratios increased in FRD (P < 0.05) dogs during treatment. Plasma glucose concentration was lower in FRD dogs before treatment than in C (P < 0.05), and NEFA concentrations were higher in FRDdogs before and after treatment than in C (P < 0.001). Haptoglobin concentrations were higher in IBD dogs before and after treatment than in all other groups (P < 0.05). In conclusion, chronic enteropathies reduce the plasma IGF-1 status in dogs. The increase of the IGF-1/BW ratio after treatment suggests that plasma IGF-1 concentration may help to judge the outcome of chronic enteropathies in dogs.

Keywords: plasma insulin-like growth factor; metabolites; haptoglobin; food responsive diarrhea; inflammatory bowel disease

Published: January 31, 2006  Show citation

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Spichiger AC, Allenspach K, Zbinden Y, Doherr MG, Hiss S, Blum JW, Sauter SN. Plasma insulin-like growth factor-1 concentration in dogs with chronic enteropathies. Vet Med - Czech. 2006;51(1):35-43. doi: 10.17221/5515-VETMED.
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