Veterinární medicína, 2025 (vol. 70), issue 7
Animal models of autism spectrum disorder: Insights into genetic, structural and environmental modelsReview
D Chivchibashi-Pavlova, K Bratoeva
Vet Med - Czech, 2025, 70(7):227-241 | DOI: 10.17221/87/2024-VETMED 
Autism spectrum disorder (ASD) is a group of human neurodevelopmental disorders with significant global prevalence. Deficits in social communication and interaction and repetitive, stereotyped patterns of behaviour characterise ASD. The aetiology of ASD is unclear, but several genetic and environmental risk factors, either alone or in combination, are implicated in its development. To date, the underlying pathogenic mechanisms of ASD remain incompletely understood due to its heterogeneity. To better understand the pathogenesis of ASD, various animal models have been developed. The use of animals in ASD research allows the exploration of the biological...
The use of parenteral application of ferric carboxymaltose in the prevention of iron deficiency anaemia in suckling pigletsOriginal Paper
M Svoboda, J Vasek, J Jarkovsky, V Skupien, V Vitkova
Vet Med - Czech, 2025, 70(7):242-246 | DOI: 10.17221/22/2025-VETMED
This study aimed to evaluate the effectiveness of ferric carboxymaltose injection in the prevention of anaemia in suckling piglets. In group A (n = 8), piglets were administered iron in the form of iron carboxymaltose complex (Ferinject®) at a dose of 200 mg i.m. (neck muscle) at the age of 3 days. In group B (n = 8), piglets were given iron in the form of iron dextran (Ferribion®) at a dose of 200 mg i.m. (neck muscle) at the age of 3 days. In group C (n = 8, anaemic control group), iron was not administered until the age of 10 days. During the study, no statistically significant differences were...
Exploring minocycline’s effect on retinal degeneration following N-methyl-N-nitrosourea exposure in ratsOriginal Paper
B Karabulut, H Eroksuz, Y Eroksuz, M Gul
Vet Med - Czech, 2025, 70(7):247-260 | DOI: 10.17221/122/2024-VETMED
Retinal degeneration (RD) is often associated with deficiencies or the inaccurate production of photoreceptor-specific proteins, which are encoded by various genes and characterised by the apoptotic and ongoing death of photoreceptor cells. This study involved administering a single intraperitoneal (i.p.) dose of 50 mg/kg of N-methyl-N-nitrosourea (MNU) to rats to induce RD. Some of these rats also received intraperitoneal minocycline at varying doses to prevent RD. Euthanasia was conducted at five intervals: at 12, 24, 48, and 72 h, and on the 7th day; and eye samples were taken. These samples were analysed using histopathology,...
Toxicity of oxalic acid and its toxic effect on antioxidative enzymes in honey bee larvaeOriginal Paper
T Majchrak, M Ratvaj, L Sabova, J Toporcak, L Molnar
Vet Med - Czech, 2025, 70(7):261-271 | DOI: 10.17221/18/2025-VETMED
The production of food of plant origin is critically dependent on the pollination ability of honey bees, whose health has been deteriorating for a long time, and whose population is declining. In our in vivo experiment on a honey bee brood at the 4-day larval stage, we tested the following concentrations of oxalic acid: 0% (control – applied distilled water), 0.87%, 1.75%, 3.5% and 7%, corresponding to doses of 0 mg, 2.61 mg, 5.25 mg, 10.5 mg, and 21 mg of oxalic acid per dm2 of honeycomb with the brood. The LC50 values (72 h) ranged between 3.17% and 3.33%. The different LC50 values obtained resulted from...