Vet Med - Czech, 2025, 70(7):242-246 | DOI: 10.17221/22/2025-VETMED

The use of parenteral application of ferric carboxymaltose in the prevention of iron deficiency anaemia in suckling pigletsOriginal Paper

M Svoboda1, J Vasek1, J Jarkovsky2, V Skupien3, V Vitkova3
1 Ruminant and Swine Clinic, Faculty of Veterinary Medicine, University of Veterinary Sciences Brno, Brno, Czech Republic
2 Institute of Biostatistics and Analyses, Faculty of Medicine, Masaryk University Brno, Brno, Czech Republic
3 Faculty of Veterinary Medicine, University of Veterinary Sciences Brno, Brno, Czech Republic

This study aimed to evaluate the effectiveness of ferric carboxymaltose injection in the prevention of anaemia in suckling piglets. In group A (n = 8), piglets were administered iron in the form of iron carboxymaltose complex (Ferinject®) at a dose of 200 mg i.m. (neck muscle) at the age of 3 days. In group B (n = 8), piglets were given iron in the form of iron dextran (Ferribion®) at a dose of 200 mg i.m. (neck muscle) at the age of 3 days. In group C (n = 8, anaemic control group), iron was not administered until the age of 10 days. During the study, no statistically significant differences were observed in the parameters of red blood cell count or blood plasma iron concentration between the group that received iron carboxymaltase and the group that received iron dextran. The results of haematological and biochemical examinations achieved in our study show that the application of iron carboxymaltase was successful in preventing iron deficiency anaemia in piglets. The results indicate comparable efficacy of iron carboxymaltase and iron dextran.

Keywords: carbohydrate complexes; haematocrit; haemoglobin concentration; swine

Received: March 26, 2025; Revised: March 26, 2025; Accepted: May 22, 2025; Prepublished online: July 25, 2025; Published: July 29, 2025  Show citation

ACS AIP APA ASA Harvard Chicago Chicago Notes IEEE ISO690 MLA NLM Turabian Vancouver
Svoboda M, Vasek J, Jarkovsky J, Skupien V, Vitkova V. The use of parenteral application of ferric carboxymaltose in the prevention of iron deficiency anaemia in suckling piglets. Vet Med - Czech. 2025;70(7):242-246. doi: 10.17221/22/2025-VETMED.
Share...
Download citation
  • BibTeX (.bib)
  • Bookends (.ris)
  • EasyBib (.ris)
  • EndNote (.enw)
  • EndNote 8 (.xml)
  • ISI WoS (.isi)
  • Medlars (.medlars)
  • Mendeley (.ris)
  • MODS (.xml)
  • Papers (.ris)
  • RefWorks (.txt)
  • RefManager (.ris)
  • RIS (.ris)
  • MS Word (.xml)
  • Zotero (.ris)
    • Open full article

    References

    1. Bhattarai S, Nielsen JP. Early indicators of iron deficiency in large piglets at weaning. J Swine Health Prod. 2015 Jan;23(1):10-7. Go to original source...
    2. Egeli AK, Framstad T, Morberg H. Clinical biochemistry, haematology and body weight in piglets. Acta Vet Scand. 1998;39(3):381-93. Go to original source... Go to PubMed...
    3. Evstatiev R, Marteau P, Iqbal T, Khalif IL, Stein J, Bokemeyer B, Chopey IV, Gutzwiller FS, Riopel L, Gasche C. FERGIcor, a randomized controlled trial on ferric carboxymaltose for iron deficiency anemia in inflammatory bowel disease. Gastroenterology. 2011 Sep;141(3):846-853.e1-2. Go to original source... Go to PubMed...
    4. Fishbane S, Ungureanu VD, Maesaka JK, Kaupke CJ, Lim V, Wish J. The safety of intravenous iron dextran in hemodialysis patients. Am J Kidney Dis. 1996 Oct;28(4):529-34. Go to original source... Go to PubMed...
    5. Geisser P, Burckhardt S. The pharmacokinetics and pharmacodynamics of iron preparations. Pharmaceutics. 2011 Jan 4;3(1):12-33. Go to original source... Go to PubMed...
    6. Haugegaard J, Wachmann H, Kristensen PJ. Effect of supplementing fast growing late-weaned piglets twice with 200 mg iron dextran intra-muscular. Pig J. 2008 Jan;61:69-73.
    7. Hirayama KJ, Yasutake K. Free radicals and trace elements. J Trace Elem Exper Med. 1998 Dec 7;11(2-3):209-17. Go to original source...
    8. Holmgren N. Polyarthritis in piglets caused by iron dextran. Proc 14th IPVS Congress; Bologna, Italy; 1996. 603 p.
    9. Hussain I, Bhoyroo J, Butcher A, Koch TA, He A, Bregman DB. Direct comparison of the safety and efficacy of ferric carboxymaltose versus iron dextran in patients with iron deficiency anemia. Anemia. 2013 Aug 29;2013:169107. Go to original source... Go to PubMed...
    10. Kaneko JJ. Clinical biochemistry of domestic animals. 4th edition. New York: Academic Press; 1993. 932 p.
    11. Keating GM. Ferric carboxymaltose: A review of its use in iron deficiency. Drugs. 2015 Jan;75(1):101-27. Go to original source... Go to PubMed...
    12. Koduru P, Abraham BP. The role of ferric carboxymaltose in the treatment of iron deficiency anemia in patients with gastrointestinal disease. Therap Adv Gastroenterol. 2016 Jan;9(1):76-85. Go to original source... Go to PubMed...
    13. Kolb E, Hoffmann U. Zur Frage der zweckmassigen Form der Anwendung von Fe-dextran, seiner Verwertung sowie des Mechanismus einer moglichen Schadigung der Ferkl [On the question of the appropriate form of application of Fe-dextran, its utilization, and the mechanism of possible damage to piglets]. Mh Vet Med. 1989;44:497-501. German.
    14. Maes D, Steyaert M, Vanderhaeghe C, Lopez Rodríguez A, de Jong E, Del Pozo Sacristan R, Vangroenweghe F, Dewulf J. Comparison of oral versus parenteral iron supplementation on the health and productivity of piglets. Vet Rec. 2011 Feb 19;168(7):188. Go to original source... Go to PubMed...
    15. Morris CJ, Earl JR, Trenam CW, Blake DR. Reactive oxygen species and iron - A dangerous partnership in inflammation. Int J Biochem Cell Biol. 1995 Feb;27(2):109-22. Go to original source... Go to PubMed...
    16. Patterson DS, Allen WM, Berrett S, Sweasey D, Done JT. The toxicity of parenteral iron preparations in the rabbit and pig with a comparison of the clinical and biochemical responses to iron-dextrose in 2 days old and 8 days old piglets. Zentralbl Veterinarmed A. 1971 Aug;18(6):453-64. Go to original source... Go to PubMed...
    17. Suveges T, Glavits R. Piglet losses due to parenteral application of iron-dextran preparations. Acta Vet Acad Sci Hung. 1976;26(3):257-62.
    18. Svoboda M, Vanhara J, Berlinska J. Parenteral iron administration in suckling piglets - A review. Acta Vet Brno. 2017 Oct;86(3):249-61. Go to original source...

    This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International (CC BY NC 4.0), which permits non-comercial use, distribution, and reproduction in any medium, provided the original publication is properly cited. No use, distribution or reproduction is permitted which does not comply with these terms.


    Return to the content