Vet Med - Czech, 2007, 52(11):521-525 | DOI: 10.17221/2065-VETMED

Gynaecomastia in a tom-cat caused by cyproterone acetate: a case report

F. Jelinek1, R. Barton2, J. Posekana2, L. Hasonova3
1 Veterinary Histopathological Laboratory, Prague, Czech Republic
2 Veterinary Clinic of Small Animals, Ceske Budejovice, Czech Republic
3 Faculty of Agriculture, University of South Bohemia, Ceske Budejovice, Czech Republic

The contribution demonstrates gynaecomastia in an adult, noncastrated tom-cat, caused by an antiandrogenic preparation Androcur tablets (Schering AG, BRD), administrated at the dose of 5 mg/day for one week. Two months after the treatment, the enlargement of all mammary glands was apparent and one month later (i.e. three months after the end of drug administration) the mammary chains reached the size of 30 × 15 × 20 cm. The general health state of the animal was altered due to the conspicuous enlargement and inflammation of mammary glands. Radical mastectomy was done under general anaesthesia using Isoflurane Rhone-Poulenc inh. The weight of the extirpated mammary chains was 1.75 kg. The healing of operative wounds and convalescence occurred without complications. Fibroepithelial hyperplasia of mammary glands was diagnosed histologically.

Keywords: tom-cat; gynaecomastia; Androcur

Published: November 30, 2007  Show citation

ACS AIP APA ASA Harvard Chicago Chicago Notes IEEE ISO690 MLA NLM Turabian Vancouver
Jelinek F, Barton R, Posekana J, Hasonova L. Gynaecomastia in a tom-cat caused by cyproterone acetate: a case report. Vet Med - Czech. 2007;52(11):521-525. doi: 10.17221/2065-VETMED.
Download citation

References

  1. Bethlehem M., van der Luer R.J. (1993): Feline fibroepithelial hyperplasia in 3 castrated tomcats following treatment with progestagens. Tijdschrift Voor Diergeneeskunde, 15, 650-652.
  2. De Souza T.M., Fighere R.A., Langohr I.M., de Bartos C.S.L. (2002): Hiperplasia fibroepithelial mamaria em felinos: Cinco casos. Ciencia Rural, Santa Maria, 32, 891-894. Go to original source...
  3. Dolezel R., Vitasek R., Senior D.F. (2001): Disturbances of reproductive system. In: Svoboda M., Senior D.F., Doubek J., Klimes J. (eds.): Diseases in Dogs and Cats (in Czech). 2nd vol. Novico, Czech Small Animal Veterinary Association, Brno. 1253-1357.
  4. Doubek J., Klimes J., Senior D.F., Kohout P., Benak J., Svoboda M., Svobodova V. (2001): Practices of Laboratory Diagnostic. In: Svoboda M., Senior D.F., Doubek J., Klimes J. (eds.): Diseases in Dogs and Cats (in Czech). 1st.vol. Novico, Czech Small Animal Veterinary Association, Brno. 57-86.
  5. Gorlinger S., Kolostra H.S., van den Broek A., Oklene A.C. (2002): Treatment of fibroadenomatous hyperplasia in cats with aglepristone. Journal of Veterinary Internal Medicine, 16, 710-713. Go to original source... Go to PubMed...
  6. Foster R.A. (2007): Female reproductive system. In: McGavin M.D., Zachary J.F. (eds.): Pathologic Basis of Veterinary Disease. 4th ed. Mosby Elsevier, St. Louis, Missouri. 1263-1315.
  7. Hayden D.W., Johnston S.D., Kisny D.T., Johnson K.H., Barnes D.M. (1981): Feline mammary hypertrophy/fibroadenoma complex: clinical and hormonal aspects. American Journal of Veterinary Research, 42, 1699- 1703. Go to original source...
  8. Hayden D.W., Barnes D.M., Johnson K.H. (1989): Morphologic changes in the mammary gland of megestrol acetate-treated and untreated cats: a retrospective study. Veterinary Pathology, 26, 104-113. Go to original source... Go to PubMed...
  9. Hinton M., Gaskell C.J. (1977): Non-neoplastic mammary hypertrophy in the cat associated ether with pregnancy or with oral progestagen therapy. Veterinary Record, 100, 277-280. Go to original source... Go to PubMed...
  10. Loretti A.P., Ilha M.R.S., Breitsameter I., Faraco C.S. (2005): Clinical and pathological study of feline fibroadenomatous change associated with depot medroxyprogesterone acetate therapy. Journal of Feline Medicine and Surgery, 7, 43-52. Go to original source... Go to PubMed...
  11. MacDougall L.D. (2003): Mammary fibroadenomatous hyperplasia in a young cat attributed to treatment with megestrol acetate. Canadian Veterinary Journal, 44, 227-229.
  12. Meisl D., Hubler M., Arnold S. (2003): Treatment of fibroepithelial hyperplasia (FEH) of the mammary gland in the cat with the progesterone antagonist Aglepristone (Alizine). Schweizerische Archiv fur Tierheilkunde, 145, 130-136. Go to original source... Go to PubMed...
  13. Misdorp W. (2002): Tumors of the mammary gland. In: Meuten D.J. (ed.): Tumors in Domestic Animals. 4th ed. Iowa State Press. 575-606. Go to original source...
  14. Misdorp W., Else R.W., Hellmen E., Lipscomb T.P. (1999): Histological Classification of Mammary Tumors of the Dog and the Cat. Armed Forces Institute of Pathology, Washington, D.C. 58 pp.
  15. Mol J.A., VanGarderen E., Rutteman G.R., Rijnberk A. (1996): New insights in the molecular mechanism of protestin-induced proliferation of mammary epithelium: induction of the local synthesis of growth hormone (GH) in the mammary glands of dogs, cats and humans. Journal of Steroid Biochemistry and Molecular Biology, 57, 67-71. Go to original source... Go to PubMed...
  16. Romagnoli S., Concannon P.W. (2003): Clinical use of progestins in bitches and queens: a review. In: Concannon P.W., England G., Verstegen J., Linde-Forsberg C. (eds.): Recent Advances in Small Animal Reproduction. International Veterinary Information Service (www.ivis.org), Ithaca, New York, USA. A1206.0903.
  17. Suchopar J. (1997): Remedia Compendium. 2nd publication. Drugs used to therapy of diseases of endocrine system (in Czech). Panax, Praha.
  18. Vitasek R., Dendisova H. (2006): Treatment of feline mammary fibroepithelial hyperplasia following a single injection of proligestone. Acta Veterinaria Brno, 75, 295-297. Go to original source...
  19. Zertova H. (2001): Disorders of behaviour in dogs and cats. In: Svoboda M., Senior D.F., Doubek J., Klimes J. (eds.): Diseases in Dogs and Cats (in Czech). 2nd vol. Novico, Czech Small Animal Veterinary Association. 1645-1679.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International (CC BY NC 4.0), which permits non-comercial use, distribution, and reproduction in any medium, provided the original publication is properly cited. No use, distribution or reproduction is permitted which does not comply with these terms.