Vet Med - Czech, 2015, 60(10):539-543 | DOI: 10.17221/8492-VETMED

Post-calving administration of uterine stimulants does not improve reproductive performance in dairy cowsOriginal Paper

K. Holickova, R. Dolezel, S. Cech
University of Veterinary and Pharmaceutical Sciences Brno, Czech Republic

The aim of this study was to evaluate the effects of administration of oxytocin, in combination with dinoprost or ergometrin, after parturition on the occurrence of clinical endometritis and subsequent reproductive performance in dairy cows. The cows, without retained foetal membranes, were assigned to one of three groups. No treatment was performed in the control group (Group C, n = 229). However, intramuscular administrations of oxytocin (30 IU) on Days 1 and 2 post partum, in combination with dinoprost (25 mg, Group D, n = 123) or ergometrin (15 mg, Group E, n = 130) administered on Day 7 post partum, were performed in experimental groups. Vaginal discharge score (VDS, 1-5), uterine content score (UCS, 1-3) on Day14 to 21 post partum, number of treatment interventions (TI), proportion of non-treated cows (NT) because of endometritis, calving to first insemination interval (CI), first insemination conception rate (CR), and proportion of pregnant cows by Day 150 post partum (PC), were compared among groups. There was no significant difference among groups for any parameter. Average values were 2.08, 2.24 and 2.06 (VDS); 1.49, 1.51 and 1.45 (UCS); 0.86, 0.93 and 0.74 (TI); 59.4, 54.2 and 54.7% (NT); 73.9 ± 15.2, 75.4 ± 17 and 74.2 ± 17 days (CI); 41.4, 38.9 and 44.3% (CR); and 75.4, 77.7 and 80.5% (PC) for Groups C, D and E, respectively. There was no significant benefit of preventive administration of oxytocin, in combination with dinoprost or ergometrin, after parturition on reproductive performance in dairy cows.

Keywords: cow; endometritis; oxytocin; dinoprost; ergometrin; reproductive parameters

Published: October 31, 2015  Show citation

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Holickova K, Dolezel R, Cech S. Post-calving administration of uterine stimulants does not improve reproductive performance in dairy cows. Vet Med - Czech. 2015;60(10):539-543. doi: 10.17221/8492-VETMED.
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References

  1. Bajcsy AC, Szenci O, van der Weijden GC, Doornenbal A, Maassen F, Bartyik J, Taverne MAM (2006): The effect of a single oxytocin or carbetocin treatment on uterine contractility in early postpartum dairy cows. Theriogenology 65, 400-414. Go to original source... Go to PubMed...
  2. Barrett AJ, Murray RD, Christley RM, Dobson H, Smith RF (2009): Effects of the administration of oxytocin or carbetocin to dairy cows at parturition on their subsequent fertility. Veterinary Record 165, 623-626. Go to original source... Go to PubMed...
  3. Borsberry S, Dobson H (1989): Periparturient diseases and their effect on reproductive performance in five dairy herds. Veterinary Record 124, 217-219. Go to original source... Go to PubMed...
  4. Dolezel R, Vecera M, Palenik T, Cech S, Vyskocil M (2008): Systematic clinical examination of early postpartum cows and treatment of puerperal metritis did not have any beneficial effect on subsequent reproductive performance. Veterinarni Medicina 53, 59-69. Go to original source...
  5. Dubuc J, Duffield TF, Leslie KE, Walton JS, LeBlanc SJ (2011): Randomized clinical trial of antibiotic treatments for uterine health and reproductive performance in dairy cows. Journal of Dairy Science 94, 1325-1338. Go to original source... Go to PubMed...
  6. Fourichon C, Seegers H, Malher X (2000): Effect of disease on reproduction of the dairy cow: a meta-analysis. Theriogenology 53, 1729-1759. Go to original source... Go to PubMed...
  7. Gajewski Z, Thun R, Faundez R, Boryczko Z (1999): Uterine motility in the cow during puerperium. Reproduction in Domestic Animals 34, 185-191. Go to original source...
  8. Haimerl P, Heuwieser W, Arlt S (2013): Therapy of bovine endometritis with prostaglandin F2α: A meta-analysis. Journal of Dairy Science 96, 2973-2987. Go to original source... Go to PubMed...
  9. Hickey GJ, White ME, Wickenden RP, Armstrong DA (1984): Effects of oxytocin on placental retention following dystocia. Veterinary Record 25, 189-190. Go to original source... Go to PubMed...
  10. Hirsbrunner G, Kűpfer U, Burkhardt H, Steiner A (1998): Effect of different prostaglandins on intrauterine pressure and uterine motility during diestrus in experimental cows. Theriogenology 50, 445-455. Go to original source... Go to PubMed...
  11. Kaufmann TB, Westermann S, Drillich M, Plontzke J, Heuwieser (2010): Systemic antibiotic treatment of clinical endometritis in dairy cows with ceftiofur or two doses of cloprostenol in a 14-d interval. Animal Reproduction Science 121, 55-62. Go to original source... Go to PubMed...
  12. Kaya D, Ay SS, Kucukaslan I, Beceriklisoy HB, Agaoglu AR, Findik M, Ozyurtlu N, Aslan S (2012): The effectiveness of combined preventive treatment with ceftiofur, oxytocin and PGF2α on fertility parameters in cows. Revue de Medecine Veterinaire 163, 302-308.
  13. Kudlac E, Zamecnik B (1984): Effects of carbetocin (Depotocin inj. Spofa) on prevention of retained placenta in postpartum cows (in Czech). Biologizace a chemizace zivocisne vyroby - veterinaria 20, 131-140.
  14. McClary DG, Putnam MR, Wright JC, Sartin Jr JL (1989): Effect of early postpartum treatment with prostaglandin F2α on subsequent fertility in the dairy cow. Theriogenology 31, 565-570. Go to original source... Go to PubMed...
  15. McDougall S, Macaulay R, Compton C (2007): Association between endometritis diagnosis using a novel intravaginal device and reproductive performance in dairy cattle. Animal Reproduction Science 98, 9-23. Go to original source... Go to PubMed...
  16. McDougall S, de Boer M, Compton C, LeBlanc S (2013): Clinical trial of treatment programs for purulent vaginal discharge in lactating dairy cattle in New Zealand. Theriogenology 79, 1139-1145. Go to original source... Go to PubMed...
  17. McLaughlin CL, Stanisiewski EP, Risco CA, Santos JE, Dahl GE, Chebel RC, LaGrow C, Daugherty C, Bryson L, Weigel D, Hallberg J, Lucas MJ (2013): Evaluation of ceftiofur crystalline free acid sterile suspension for control of metritis in high-risk lactating dairy cows. Theriogenology 97, 725-734. Go to original source... Go to PubMed...
  18. Mollo A, Veronesi MC, Cairoli F, Soldano F (1997): The use of oxytocin for the reduction of cow placental retention and subsequent endometritis. Animal Reproduction Science 48, 47-51. Go to original source... Go to PubMed...
  19. Palomares RA, Gutierrez JC, Portillo G, Boscan JC, Montero M, Lopez Y, Maxwell HS, Carson RL, Soto E (2010): Oxytocin treatment immediately after calving does not reduce the incidence of retained fetal membranes or improve reproductive performance in crossbred Zebu cows. Theriogenology 74, 1414-1419. Go to original source... Go to PubMed...
  20. Sheldon IM, Lewis GS, LeBlanc S, Gilbert RO (2006): Defining post-partum uterine disease in cattle. Theriogenology 65, 1516-1530. Go to original source... Go to PubMed...
  21. Sheldon IM, Williams EJ, Miller ANA, Nash DM, Herath S (2008): Uterine diseases in cattle after parturition. Veterinary Journal 176, 115-121. Go to original source... Go to PubMed...
  22. Tsousis G, Sharifi AR, Hoedemaker M (2010): Increased risk of conception failure in German Holstein Friesian cows with chronic endometritis. Reproduction in Domestic Animals 45, 1114-1117. Go to original source... Go to PubMed...
  23. Williams EJ (2013): Drivers of post-partum uterine disease in dairy cattle. Reproduction in Domestic Animals 48, 53-58. Go to original source... Go to PubMed...
  24. Williams EJ, Fischer DP, Pfeiffer DU, England GCW, Noakes DE, Dobson H, Sheldon IM (2005): Clinical evaluation of postpartum vaginal mucus reflects uterine bacterial infection and the immune response in cattle. Theriogenology 63, 102-117. Go to original source... Go to PubMed...
  25. Young IM, Anderson DB (1986): Improved reproductive performance of dairy cows treated with dinoprost tromethamine soon after calving. Theriogenology 26, 199-208. Go to original source... Go to PubMed...

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