Vet Med - Czech, 2018, 63(1):36-39 | DOI: 10.17221/123/2017-VETMED
Unusual hyperthermia related to general anaesthesia in an Anatolian shepherd dogCase Report
- 1 Faculty of Veterinary Medicine, Istanbul, Turkey
- 2 Veterinary Surgeon, Bath, England
This case report describes the diagnosis, the treatment options available in the absence of dantrolene and outcome of anaesthesia-related hyperthermia seen for the first time in an Anatolian shepherd dog. The case consisted of a nine-month-old male Anatolian shepherd dog with bilateral antebrachium fractures. For surgical treatment, the patient was pre-medicated with xylazine; anaesthesia was induced using ketamine and maintained with isoflurane. Approximately 40 minutes after isoflurane administration, tachypnoea, tachycardia, increase in body temperature and rigidity in the forelegs and masseter muscles was noticed. Inhalation anaesthesia was discontinued and hyperventilation was performed with 100% O2. Due to its vasodilatory properties, diazepam was administered both to achieve muscle relaxation and to decrease body temperature. Alfentanil was used in an attempt to lower respiratory and heart rates. Intravenous administration of cold crystalloid solutions and external ice packs was used to lower body temperature. All these interventions kept the patient alive.
Keywords: hyperthermia; respiratory rate; heart rate; muscle rigidity; diazepam; alfentanil
Published: January 31, 2018 Show citation
References
- Adami C, Axiak S, Raith K, Spadavecchia C (2012): Unusual perianesthetic malignant hyperthermia in a dog. Journal of the American Veterinary Medical Association 240, 450-453.
Go to original source...
Go to PubMed...
- Antognini JF (1995): Creatine kinase alterations after acute malignant hyperthermia episodes and common surgical procedures. Anesthesia and Analgesia 81, 1039-1042.
Go to original source...
- Barhoumi R, Burghardt RC, Qian YC, Tiffany-Castiglioni E (2007): Effects of propofol on intracellular Ca+2 homeostasis in human astrocytoma cells. Brain Research 1145, 11-18.
Go to original source...
Go to PubMed...
- Brunson DB, Hogan KJ (2004): Malignant hyperthermia: a syndrome not a disease. Veterinary Clinics of North America. Small Animal Practice 34, 1419-1433.
Go to original source...
Go to PubMed...
- Chohan AS, Greene SA (2011): Anesthesia case of the month. Malignant hyperthermia. JAVMA-Journal of the American Veterinary Medical Association 239, 936-940.
Go to original source...
Go to PubMed...
- Fruen BR, Mickelson JR, Roghair TJ, Litterer LA, Louis CF (1995): Effects of propofol on Ca+2 regulation by malignant hyperthermia-susceptible muscle membranes. Anesthesiology 82, 1274-1282.
Go to original source...
Go to PubMed...
- Gronert GA, Milde JH (1981): Variations in onset of porcine malignant hyperthermia. Anesthesia and Analgesia 60, 499-503.
Go to original source...
- Kahraman NK, Kantarci G, Kahraman C (2009): Case report of an acute uremia secondary to rhabdomyolysis and hypovolemia. Turkish Nephrology, Dialysis and Transplantation Journal 18, 90-93.
- Kirmayer AH, Klide AM, Purvance JE (1984): Malignant hyperthermia in a dog - Case report and review of the syndrome. JAVMA-Journal of the American Veterinary Medical Association 185, 978-982.
Go to original source...
- Krause T, Gerbershagen MU, Fiege M, Weisshorn R, Wappler F (2004): Dantrolene - A review of its pharmacology, therapeutic use and new developments. Anaesthesia 59, 364-373.
Go to original source...
Go to PubMed...
- Lamont LA, Mathews KA (2007): Opioids, nonsteroidal anti-inflammatories, and analgesic adjuvants. In: Tranquilli WJ, Thurmon JC, Grimm KA (eds): Lumb and Jones' Veterinary Anesthesia and Analgesia. 4th edn. Blackwell Publishing, Iowa. 241-271.
- Lemke KA (2007): Anticholinergics and sedatives. In: Tranquilli WJ, Thurmon JC, Grimm KA (eds): Lumb and Jones' Veterinary Anesthesia and Analgesia. 4th edn. Blackwell Publishing, Iowa. 203-239.
- Migita T, Mukaida K, Kawamoto M, Kobayashi M, Nishino I, Yuget O (2007): Propofol-induced changes in myoplasmic calcium concentrations in cultured human skeletal muscles from RYR1 mutation carriers. Anaesthesia and Intensive Care 35, 894-898.
Go to original source...
Go to PubMed...
- Murao K, Umegaki T, Masuzawa M, Masuzawa M, Inoue S, Nakao S, Shingu K (2010): Propofol triggers a marked body temperature increase in a patient with fulminant malignant hyperthermia (MH) without inducing other symptoms of MH. The Japanese Journal of Anesthesiology 59, 92-96.
- Nelson TE (1991): Malignant hyperthermia in dogs. Journal of the American Veterinary Medical Association 198, 989-994.
Go to original source...
- O'Brien PJ, Cribb PH, White RJ, Olfert ED, Steiss JE (1983): Canine malignant hyperthermia - Diagnosis of susceptibility in a breeding colony. Canadian Veterinary Journal 24, 172-177.
- Roberts MC, Mickelson JR, Patterson EE, Nelson TE, Armstrong PJ, Brunson DB, Hogan K (2001): Autosomal dominant canine malignant hyperthermia is caused by a mutation in the gene encoding the skeletal muscle calcium release channel (RYR1). Anesthesiology 95, 716- 725.
Go to original source...
Go to PubMed...
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