Vet Med - Czech, 2022, 67(10):538-543 | DOI: 10.17221/183/2020-VETMED

A case of carboxyatractyloside intoxication by ingestion of the cocklebur (Xanthium strumarium) in a Korean native cowCase Report

SG Roh1, J Kim1, S Kim2, BJ So1, K Lee1
1 Animal Disease Diagnostic Division, Animal and Plant Quarantine Agency (APQA), Gimcheon, Republic of Korea
2 National Forensic Service, Wonju, Republic of Korea

A 19-month-old Korean native cow died the following day after consuming new silage. Grossly, the liver showed enlargement, redness, and haemorrhages in all the lobes. Additionally, many of the bur-shaped fruits of the cocklebur (Xanthium strumarium) were found in the gastric contents. The histological evaluation confirmed centrilobular hepatic necrosis. Additionally, carboxyatractyloside (CATR), a material fatal to animals found in the cocklebur, was detected in the gastric contents using high-performance liquid chromatography-quadrupole-time of flight mass spectrometry (HPLC-Q-TOF-MS). Based on the pathological findings and analytical confirmation, CATR intoxication was diagnosed. Therefore, careful feeding and elimination of the cocklebur is essential for minimising economic loss.

Keywords: centrilobular hepatic necrosis; cow; silage

Received: September 14, 2020; Accepted: May 2, 2022; Prepublished online: August 2, 2022; Published: October 15, 2022  Show citation

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Roh S, Kim J, Kim S, So B, Lee K. A case of carboxyatractyloside intoxication by ingestion of the cocklebur (Xanthium strumarium) in a Korean native cow. Vet Med - Czech. 2022;67(10):538-543. doi: 10.17221/183/2020-VETMED.
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