Vet Med - Czech, 2024, 69(1):18-29 | DOI: 10.17221/100/2023-VETMED

Accidental salinomycin intoxication in European fallow deer (Dama dama L.)Case Report

M Svoboda1, O Huml2, P Chomat3, A Honzlova4, J Illek5, Z Svobodova6, L Hofmannova7, H Modra8
1 Ruminant and Swine Clinic, University of Veterinary Sciences Brno, Brno, Czech Republic
2 Vedilab Ltd Plzeň, Plzeň, Czech Republic
3 Veterinary Clinic Dobrošovice, Sedlčany, Czech Republic
4 State Veterinary Institute Jihlava, Jihlava, Czech Republic
5 Large Animal Clinical Laboratory, University of Veterinary Sciences Brno, Brno, Czech Republic
6 Department of Animal Protection and Welfare and Veterinary Public Health, University of Veterinary Sciences Brno, Brno, Czech Republic
7 State Veterinary Institute Prague, Prague, Czech Republic
8 Institute of Environmental Science and Natural Resources, Mendel University in Brno, Brno, Czech Republic

Salinomycin, belonging to ionophore antibiotics, has been used as a feed additive for poultry for its coccidiostatic effect. Poisoning by ionophore antibiotics has been reported in cattle and other sensitive animals due to the replacement of medicated feed and/or accidental overdoses. The aim of this paper is to report the toxicity of salinomycin for fallow deer and to describe the different levels of sensitivity of cervids to this substance. In the presented case study, a medicated feed containing ivermectin used for deworming red deer and fallow deer was accidentally contaminated with sodium salinomycinate in a concentration of 252.6 mg/kg. The contaminated feed was consumed by the animals over a period of four days. The mortality of fallow deer within 12 days was 58%. No mortality was recorded in the red deer. In the affected animals, clinical signs associated with acute and congestive heart failure were observed. The biochemical examination indicated prerenal azotaemia caused by circulatory insufficiency and ion imbalance. The histological examination revealed pronounced focal acute cardiomyopathy and massive subacute myopathy in the skeletal muscles.

Keywords: deer farm; creatin kinase; hyperkalaemia; hypochloraemia; urea

Received: September 29, 2023; Revised: September 29, 2023; Accepted: November 10, 2023; Prepublished online: January 23, 2024; Published: January 25, 2024  Show citation

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Svoboda M, Huml O, Chomat P, Honzlova A, Illek J, Svobodova Z, et al.. Accidental salinomycin intoxication in European fallow deer (Dama dama L.). Vet Med - Czech. 2024;69(1):18-29. doi: 10.17221/100/2023-VETMED.
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