Vet Med - Czech, 2025, 70(1):30-34 | DOI: 10.17221/51/2024-VETMED

Successful pregnancy of a Maine Coon queen despite feline mammary fibroadenomatous hyperplasia recurrence after treatment with aglepristoneCase Report

P Socha1, P Mossakowski2
1 Department of Animal Reproduction with Clinic, Faculty of Veterinary Medicine, University of Warmia and Mazury in Olsztyn, Olsztyn, Poland
2 Private Veterinary Practice “Zwierzyniec”, Gdansk, Poland

One of the disorders of the mammary gland in the queen is feline mammary fibroadenomatous hyperplasia (FMFH), caused by an increasing concentration of progesterone (P4) and some other local growth factors. It occurs mostly during puberty after the heat characterised by spontaneous or provoked ovulation, as a result of exogenous progesterone intake and sometimes during pregnancy. To diagnose a 14-month-old intact Maine Coon queen with extensive mammary gland hyperplasia, a clinical examination, analyses of the progesterone (P4) concentrations and ultrasound examination were performed. Feline mammary fibroadenomatous hyperplasia associated with a high P4 concentration after spontaneous ovulation was confirmed. After 24 days of therapy with a progesterone antagonist, aglepristone, the symptoms of FMFH resolved. After the next eight weeks, the queen was mated after the owner’s decision. In the third week of pregnancy, a relapse was detected (mammary gland enlargement, pain, discomfort). At the same time, no abnormalities in the uterus or embryos were detected via ultrasound. The P4 concentrations were under regular control. For the next two weeks, only conservative treatment with NSAIDs was used. The queen spontaneously delivered six kittens without any difficulties or perinatal complications 67 days after the first mating. The cat previously treated with aglepristone for FMFH was successfully bred, but FMFH symptoms returned when progesterone concentrations increased during pregnancy.

Keywords: antiprogestagen; cat; FMFH

Received: June 12, 2024; Revised: October 9, 2024; Accepted: November 19, 2024; Prepublished online: January 15, 2025; Published: January 20, 2025  Show citation

ACS AIP APA ASA Harvard Chicago Chicago Notes IEEE ISO690 MLA NLM Turabian Vancouver
Socha P, Mossakowski P. Successful pregnancy of a Maine Coon queen despite feline mammary fibroadenomatous hyperplasia recurrence after treatment with aglepristone. Vet Med - Czech. 2025;70(1):30-34. doi: 10.17221/51/2024-VETMED.
Share...
Download citation
  • BibTeX (.bib)
  • Bookends (.ris)
  • EasyBib (.ris)
  • EndNote (.enw)
  • EndNote 8 (.xml)
  • ISI WoS (.isi)
  • Medlars (.medlars)
  • Mendeley (.ris)
  • MODS (.xml)
  • Papers (.ris)
  • RefWorks (.txt)
  • RefManager (.ris)
  • RIS (.ris)
  • MS Word (.xml)
  • Zotero (.ris)
    • Open full article

    References

    1. Burstyn U. Management of mastitis and abscessation of mammary glands secondary to fibroadenomatous hyperplasia in a primiparturient cat. J Am Vet Med Assoc. 2010 Feb 1;236(3):326-9. Go to original source... Go to PubMed...
    2. Choi EY, Jeong HE, Noh Y, Choi A, Yon DK, Han JY, Sung JH, Choe SA, Shin JY. Neonatal and maternal adverse outcomes and exposure to nonsteroidal anti-inflammatory drugs during early pregnancy in South Korea: A nationwide cohort study. PLoS Med. 2023 Feb;20(2):e1004183. Go to original source... Go to PubMed...
    3. Gorlinger S, Kooistra HS, van den Broek A, Okkens AC. Treatment of fibroadenomatous hyperplasia in cats with aglepristone. J Vet Intern Med. 2002;16(6):710. Go to original source...
    4. Jurka P, Max A. Treatment of fibroadenomatosis in 14 cats with aglepristone: Changes in blood parameters and follow-up. Vet Rec. 2009 Nov;165(22):657-60. Go to original source... Go to PubMed...
    5. MacDougall LD. Mammary fibroadenomatous hyperplasia in a young cat attributed to treatment with megestrol acetate. Can Vet J. 2003 Mar;44(3):227-9.
    6. Marino G, Pugliese M, Pecchia F, Garufi G, Lupo V, Giorgio S, Sfacteria A. Conservative treatments for feline fibroadenomatous changes of the mammary gland. Open Vet J. 2021;11(4):680. Go to original source... Go to PubMed...
    7. Mayayo SL, Bo S, Pisu MC. Mammary fibroadenomatous hyperplasia in a male cat. J Feline Med Surg Open Rep. 2018 Jan;4(1):205511691876015. Go to original source... Go to PubMed...
    8. Martin de las Mulas J, Millan Y, Bautista MJ, Perez J, Carrasco L. Oestrogen and progesterone receptors in feline fibroadenomatous change: An immunohistochemical study. Res Vet Sci. 2000 Feb;68(1):15-21. Go to original source... Go to PubMed...
    9. Nielsen GL. Risk of adverse birth outcome and miscarriage in pregnant users of non-steroidal anti-inflammatory drugs: Population-based observational study and case-control study. BMJ. 2001 Feb;322(7281):266-70. Go to original source... Go to PubMed...
    10. Ordas J, Millan Y, de los Monteros AE, Reymundo C, Martin de las Mulas J. Immunohistochemical expression of progesterone receptors, growth hormone, and insulin growth factor-I in feline fibroadenomatous change. Res Vet Sci. 2004 Jun;76(3):227-33. Go to original source... Go to PubMed...
    11. Payan-Carreira R. Feline mammary fibroepithelial hyperplasia: A clinical approach. In: Perez-Marin CC, editor. Insights from veterinary medicine. Rijeka (Croatia): InTech; 2013. p. 215-32. Go to original source...
    12. Shille VM, Stabenfeldt GH. Luteal function in the domestic cat during pseudopregnancy and after treatment with prostaglandin F2a. Biol Reprod. 1979 Dec 1;21(5):1217-23. Go to original source... Go to PubMed...
    13. Taylor S, Gruen M, KuKanich K, Lascelles BDX, Monteiro BP, Sampietro LR, Robertson S, Steagall PV. 2024 ISFM and AAFP consensus guidelines on the long-term use of NSAIDs in cats. J Feline Med Surg. 2024 Apr;26(4). Go to original source... Go to PubMed...
    14. Torrigiani F, Moccia V, Brunetti B, Millanta F, Valdivia G, Pena L, Cavicchioli L, Zappulli V. Mammary fibroadenoma in cats: A matter of classification. Vet Sci. 2022 May;9(6):253. Go to original source... Go to PubMed...
    15. Verhage HG, Beamer NB, Brenner RM. Plasma levels of estradiol and progesterone in the cat during polyestrus, pregnancy, and pseudopregnancy. Biol Reprod. 1976 Jun;14(5):579-85. Go to original source... Go to PubMed...
    16. Zschockelt L, Amelkina O, Siemieniuch MJ, Koster S, Jewgenow K, Braun BC. Corpora lutea of pregnant and pseudopregnant domestic cats reveal similar steroidogenic capacities during the luteal lifespan. J Steroid Biochem Mol Biol. 2014 Oct;144:373-81. Go to original source... Go to PubMed...

    This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International (CC BY NC 4.0), which permits non-comercial use, distribution, and reproduction in any medium, provided the original publication is properly cited. No use, distribution or reproduction is permitted which does not comply with these terms.


    Return to the content