Vet Med - Czech, 2006, 51(5):212-223 | DOI: 10.17221/5540-VETMED

Genetically modified potato plants in nutrition and prevention of diseases in humans and animals: a review

R. Pribylova, I. Pavlik, M. Bartos
Veterinary Research Institute, Brno, Czech Republic

Genetically modified organisms (GMO) become a real constituent of our lives and nowadays, they are commonly introduced into the food chain of people and animals in some states. Among higher organisms, plants are used above all for genetic modifications; potatoes are a suitable model plants for this purpose. Nowadays, a number of various genetic modifications of potato plants are available, particularly those with increased resistance to biological agents and factors of the external environment or with improved nutritional value. Plants that produce proteins of the immune system of man or animals or substances that may be used as vaccines in human or veterinary medicine are highly important. Modified potato plants that produce biomaterials for potential applications in the industry are a significant category.

Keywords: genetically modified organisms (GMO); genetic modification; transformation; transgene; plants; Solanum tuberosum; nutrition

Published: May 31, 2006  Show citation

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Pribylova R, Pavlik I, Bartos M. Genetically modified potato plants in nutrition and prevention of diseases in humans and animals: a review. Vet Med - Czech. 2006;51(5):212-223. doi: 10.17221/5540-VETMED.
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    References

    1. Arakawa T., Chong D.K., Merritt J.L., Langridge W.H. (1997): Expression of cholera toxin B subunit oligomers in transgenic potato plants. Transgenic Research, 6, 403-413. Go to original source... Go to PubMed...
    2. Benmoussa M., Vezina L.P., Page M., Gelinas P., Yelle S., Laberge S. (2004): Potato flour viscosity improvement is associated with the expression of a wheat LMWglutenin gene. Biotechnology and Bioengineering, 87, 495-500. Go to original source... Go to PubMed...
    3. Biemelt S., Sonnewald U., Galmbacher P., Willmitzer L., Muller M. (2003): Production of human papillomavirus type 16 virus-like particles in transgenic plants. Journal of Virology, 77, 9211-9220. Go to original source... Go to PubMed...
    4. Birch A., Geoghegan I.E., Griffiths D.W., McNicol J.W. (2002): The effect of genetic transformations for pest resistance on foliar solanidine-based glycoalkaloids of potato (Solanum tuberosum). Annals Applied Biology, 140, 143-149. Go to original source...
    5. Broekaert W.F., Marien W., Terras F.R., De Bolle M.F., Proost P., Van Damme J., Dillen, L., Claeys M., Rees S.B., Vanderleyden J. (1992): Antimicrobial peptides from Amaranthus caudatus seeds with sequence homology to the cysteine/glycine-rich domain of chitinbinding proteins. Biochemistry, 31, 4308-4314. Go to original source... Go to PubMed...
    6. Carrillo C., Wigdorovitz A., Trono K., Dus Santos M.J., Castanon S., Sadir A.M., Ordas R., Escribano J.M., Borca M.V. (2001): Induction of a virus-specific antibody response to foot and mouth disease virus using the structural protein VP1 expressed in transgenic potato plants. Viral Immunology, 14, 49-57. Go to original source... Go to PubMed...
    7. Castanon S., Marin M.S., Martin-Alonso J.M., Boga J.A., Casais R., Humara J.M., Ordas R.J., Parra F. (1999): Immunization with potato plants expressing VP60 protein protects against rabbit hemorrhagic disease virus. Journal of Virology, 73, 4452-4455. Go to original source... Go to PubMed...
    8. Chakraborty S., Chakraborty N., Datta A. (2000): Increased nutritive value of transgenic potato by expressing a nonallergenic seed albumin gene from Amaranthus hypochondriacus. Proceedings of the National Academy of Sciences of the United States of America, 97, 3724-3729. Go to original source... Go to PubMed...
    9. Chong D.K., Langridge W.H. (2000): Expression of fulllength bioactive antimicrobial human lactoferrin in potato plants. Transgenic Research, 9, 71-78. Go to original source... Go to PubMed...
    10. Chong D.K., Roberts W., Arakawa T., Illes K., Bagi G., Slattery C.W., Langridge W.H. (1997): Expression of the human milk protein beta-casein in transgenic potato plants. Transgenic Research, 6, 289-296. Go to original source... Go to PubMed...
    11. Daniell H., Streatfield S.J., Wycoff K. (2001): Medical molecular farming: production of antibodies, biopharmaceuticals and edible vaccines in plants. Trends in Plant Science, 6, 219-226. Go to original source... Go to PubMed...
    12. Davies H.V. (1996): Recent developments in our knowledge of potato transgenic biology. Potato Research, 39, 411-427. Go to original source...
    13. Ewen S.W.B., Pusztai A. (1999): Effect of diets containing genetically modified potatoes expressing Galanthus nivalis lectin on rat small intestine. Lancet, 354, 1353-1354. Go to original source... Go to PubMed...
    14. Gatehouse A.M.R., Down R.E., Powell K.S., Sauvion N., Rahbe Y., Newell Ch.A., Merryweather A., Hamilton W.D.O., Gatehouse J.A. (1996): Transgenic potato plants with enhanced resistance to the peach-potato aphid Myzus persicae. Entomologia Experimetalis et Applicata, 79, 295-307. Go to original source...
    15. Gatehouse A.M.R., Davison G.M., Newell C.A., Merryweather A., Hamilton W.D.O., Burgess E.P.J., Gilbert R.J.C., Gatehouse J.A. (1997): Transgenic potato plants with enhanced resistance to the tomato moth, Lacanobia oleracea: Growth room trials. Molecular Breeding, 3, 49-63. Go to original source...
    16. Gomez N., Wigdorovitz A., Castanon S., Gil F., Ordas R., Borca M.V., Escribano J.M. (2000): Oral immunogenicity of the plant derived spike protein from swinetransmissible gastroenteritis coronavirus. Archives of Virology, 145, 1725-1732. Go to original source... Go to PubMed...
    17. Jeong M.J., Park S.C., Byun M.O. (2001): Improvement of salt tolerance in transgenic potato plants by glyceraldehyde-3 phosphate dehydrogenase gene transfer. Molecules and Cells, 12, 185-189. Go to original source... Go to PubMed...
    18. Jobling S.A., Wescott R.J., Jeffcoat R., Schwall G.P. (2002): Production of a freeze-thaw-stable potato starch by antisense inhibition of three starch synthase genes. Nature Biotechnology, 20, 295-299. Go to original source... Go to PubMed...
    19. Kehm R., Jakob N.J., Welzel T.M., Tobiasch E., Viczian O., Jock S., Geider K., Sule S., Darai G. (2001): Expression of immunogenic Puumala virus nucleocapsid protein in transgenic tobacco and potato plants. Virus Genes, 22, 73-83. Go to original source... Go to PubMed...
    20. Klaus D., Ohlrogge J.B., Neuhaus H.E., Dormann P. (2004): Increased fatty acid production in potato by engineering of acetyl-CoA carboxylase. Planta, 219, 389-396. Go to original source... Go to PubMed...
    21. Kong Q., Richter L., Yang Y.F., Arntzen C.J., Mason H.S., Thanavala Y. (2001): Oral immunization with hepatitis B surface antigen expressed in transgenic plants. Proceedings of the National Academy of Sciences of the United States of America, 98, 11539-11544. Go to original source... Go to PubMed...
    22. Lauterslager T.G., Florack D.E., van der Wal T.J., Molthoff J.W., Langeveld J.P., Bosch D., Boersma W.J., Hilgers L.A. (2001): Oral immunisation of naive and primed animals with transgenic potato tubers expressing LT-B. Vaccine, 19, 2749-2755. Go to original source... Go to PubMed...
    23. Liapkova N.S., Loskutova N.A., Maisurian A.N., Mazin V.V., Korableva N.P., Platonova T.A., Ladyzhenskaia E.P., Evsiunina A.S. (2001): Isolation of genetically modified potato plant containing the gene of defensive peptide from Amaranthus (in Russia). Applied Biochemistry and Microbiology, 37, 349-354. Go to original source...
    24. Martin-Alonso J.M., Castanon S., Alonso P., Parra F., Ordas R. (2003): Oral immunization using tuber extracts from transgenic potato plants expressing rabbit hemorrhagic disease virus capsid protein. Transgenic Research, 12, 127-130. Go to original source... Go to PubMed...
    25. Mason H.S., Ball J.M., Shi J.J., Jiang X., Estes M.K., Arntzen C.J. (1996): Expression of Norwalk virus capsid protein in transgenic tobacco and potato and its oral immunogenicity in mice. Proceedings of the National Academy of Sciences of the United States of America, 93, 5335-5340. Go to original source... Go to PubMed...
    26. Mason H.S., Haq T.A., Clements J.D., Arntzen C.J. (1998): Edible vaccine protects mice against Escherichia coli heat-labile enterotoxin (LT): potatoes expressing a synthetic LT-B gene. Vaccine, 16, 1336-1343. Go to original source... Go to PubMed...
    27. Matsumura T., Itchoda N., Tsunemitsu H. (2002): Production of immunogenic VP6 protein of bovine group A rotavirus in transgenic potato plants. Archives of Virology, 147, 1263-1270. Go to original source... Go to PubMed...
    28. Miele L. (1997): Plants as bioreactors for biopharmaceuticals: regulatory considerations. Trends in Biotechnology, 15, 45-50. Go to original source... Go to PubMed...
    29. Moire L., Rezzonico E., Poirier Y. (2003): Synthesis of novel biomaterials in plants. Journal of Plant Physiology, 160, 831-839. Go to original source... Go to PubMed...
    30. Murray P.R., Rosenthal K.S., Kobayashi G.S., Pfaller M.A. (2002): Virology. In: Medical Microbiology. 4th ed. Mosby Inc., An Affiliate of Elsevier Science, St. Louis, Missouri. 427-625.
    31. Navratil O., Vojtechova M., Fischer L., Blafkova J., Linhart M. (1998): Characterization of transgenic potato plants with an additional bacterial gene coding for phosphofructokinase. Chemical Papers, 52, 598-598.
    32. Ohya, K., Matsumura, T., Ohashi, K., Onuma, M., Sugimoto, C. (2001): Expression of two subtypes of human IFN-alpha in transgenic potato plants. Journal of Interferon and Cytokine Research, 21, 595-602. Go to original source... Go to PubMed...
    33. Ohya K., Itchoda N., Ohashi K., Onuma M., Sugimoto C., Matsumura T. (2002): Expression of biologically active human tumor necrosis factor-alpha in transgenic potato plant. Journal of Interferon and Cytokine Research, 22, 371-378. Go to original source... Go to PubMed...
    34. Osusky M., Osuska L., Hancock R.E., Kay W.W., Misra S. (2004): Transgenic potatoes expressing a novel cationic peptide are resistant to late blight and pink rot. Transgenic Research, 13, 181-190. Go to original source... Go to PubMed...
    35. Padegimas L., Shul'ga, O.A., Skriabin, K.G. (1994): Creation of transgenic plants Nicotiana tabacum and Solanum tuberosum, resistant to the herbicide phosphinothricin (in Russian). Molecular Biology, 28, 437-443.
    36. Perlak F.J., Stone T.B., Muskopf Y.M., Petersen L.J., Parker G.B., McPherson S.A., Wyman J., Love S., Reed G., Biever D., Fischhoff D.A. (1993): Genetically improved potatoes: protection from damage by Colorado potato beetles. Plant Molecular Biology, 22, 313-321. Go to original source... Go to PubMed...
    37. Romano A., Vreugdenhil D., Jamar D., van der Plas L.H.W., de Roo G., Witholt B., Eggink G., Mooibroek H. (2003): Evidence of medium-chain-length polyhydroxyoctanoate accumulation in transgenic potato lines expressing the Pseudomonas oleovorans Pha-C1 polymerase in the cytoplasm. Biochemical Engineering Journal, 16, 135-143. Go to original source...
    38. Scheller J., Guhrs K.H., Grosse F., Conrad U. (2001): Production of spider silk proteins in tobacco and potato. Nature Biotechnology, 19, 573-577. Go to original source... Go to PubMed...
    39. Selitrennikoff C.P. (2001): Antifungal Proteins. Review. Applied and Environmental Microbiology, 67, 2883- 2894. Go to original source... Go to PubMed...
    40. Slater A., Scott N.W., Fowler M.R. (eds.) (2003): Plant Biotechnology, the Genetic Manipulation of Plants. 1st ed. Oxford University Press Inc., New York, USA. 346 pp.
    41. Stirn S., Lorz H. (2003): Genetically modified plants, 26-61. In: Heller K.J. (ed.): Genetically Engineered Food. WileyVch GmbH & Co. KGaA, Weinheim. 276 pp. Go to original source...
    42. Streatfield S.J., Howard J.A. (2003): Plant-based vaccines. International Journal of Parasitology, 33, 479-493. Go to original source... Go to PubMed...
    43. Tacket C.O., Mason H.S., Losonsky G., Estes M.K., Levine M.M., Arntzen C.J. (2000): Human immune responses to a novel Norwalk virus vaccine delivered in transgenic potatoes. Journal of Infectious Diseases, 182, 302-305. Go to original source... Go to PubMed...
    44. Wallis J.G., Wang H., Guerra D.J. (1997): Expression of a synthetic antifreeze protein in potato reduces electrolyte release at freezing temperatures. Plant Molecular Biology, 35, 323-330. Go to original source... Go to PubMed...
    45. van der Wilk F., Posthumus-Lutke Willink D., Huisman M.J., Huttinga H., Goldbach R. (1991): Expression of the potato leafroll luteovirus coat protein gene in transgenic potato plants inhibits viral infection. Plant Molecular Biology, 17, 431-439. Go to original source... Go to PubMed...
    46. Wu G., Shortt B.J., Lawrence E.B., Levine E.B., Fitzsimmons K.C., Shah D.M. (1995): Disease resistance conferred by expression of a gene encoding H2O2-generating glucose oxidase in transgenic potato plants. Plant Cell, 7, 1357-1368. Go to original source... Go to PubMed...
    47. Yu J., Langridge W. (2003): Expression of rotavirus capsid protein VP6 in transgenic potato and its oral immunogenicity in mice. Transgenic Research, 12, 163-169. Go to original source... Go to PubMed...
    48. Zhou J.Y., Wu J.X., Cheng L.Q., Zheng X.J., Gong H., Shang S.B., Zhou E.M. (2003): Expression of immunogenic S1 glycoprotein of infectious bronchitis virus in transgenic potatoes. Journal of Virology, 77, 9090- 9093. Go to original source... Go to PubMed...
    49. Zhou J.Y., Cheng L.Q., Zheng X.J., Wu J.X., Shang S.B., Wang J.Y., Chen J.G. (2004): Generation of the transgenic potato expressing full-length spike protein of infectious bronchitis virus. Journal of Biotechnology, 111, 121-130. Go to original source... Go to PubMed...

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