Vet Med - Czech, 2009, 54(11):532-536 | DOI: 10.17221/43/2009-VETMED

Comparison of estradiol and progesteron serum levels in ferrets suffering from hyperoestrogenism and ovarian neoplasia

K. Hauptman1, V. Jekl1, G.M. Dorrestein2, M. Vyskocil3, Z. Knotek1
1 Avian and Exotic Animal Clinic, University of Veterinary and Pharmaceutical Sciences, Brno, Czech Republic
2 Diagnostic Laboratory of the NOIVBD (Dutch Research Institute for Birds and Exotic Animals), Veldhoven, The Netherlands
3 Institute of Genetics, University of Veterinary and Pharmaceutical Sciences, Brno, Czech Republic

The aim of this study was to determine whether serum levels of 17beta-estradiol and progesterone are significant diagnostic tools for the confirmation of specific reproductive diseases associated with hyperestrogenism. Thirty-one adult ferrets (Mustela putorrius furo) were divided into five groups. The levels of serum 17beta-estradiol differed significantly when comparing females with ovarian tumors (817.80 ± 433.90 pmol/l) to intact (83.50 ± 32.53 pmol/l) and spayed, healthy females (73.17 ± 0.41 pmol/l) as well as to females with prolonged estrus (274.75 ± 192.40 pmol/l). Concentrations of serum progesterone differed significantly when comparing females with ovarian tumours (2.10 ± 1.85 ng/ml) to intact (0.40 ± 0.40 ng/ml) and spayed, healthy females (0.30 ± 0.12 ng/ml). Our study has made it clear that a determination of serum concentrations of 17-beta estradiol and progesterone is not sufficient for distinguishing between prolonged estrus and the presence of ovarian tumours. Therefore, it is advisable to employ other clinical procedures, such as ones allowing organ visualization. Increased concentrations of 17beta-estradiol in ferrets persisted for two weeks after hCG administration. This is particularly important in clinical practice, as negative effects of estrogens on bone marrow could persist for more than 14 days. Therefore, ferrets should be clinically monitored for a longer period of time.

Keywords: hyperestrogenism; neoplasia; hormonal disease; castration

Published: November 30, 2009  Show citation

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Hauptman K, Jekl V, Dorrestein GM, Vyskocil M, Knotek Z. Comparison of estradiol and progesteron serum levels in ferrets suffering from hyperoestrogenism and ovarian neoplasia. Vet Med - Czech. 2009;54(11):532-536. doi: 10.17221/43/2009-VETMED.
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    References

    1. Ackermann J., Carpenter J.W., Godshalk C.P., Harms C.A. (1994): Ultrasonogaphic detection of adrenal gland tumors in two ferrets. Journal of the American Veterinary Medical Association, 205, 1001-1003. Go to original source...
    2. Benson K.G., Ramer J.C., Murphy J.P. (2000): Evaluating and stabilizing the critical ferret: Initial assessment, differential diagnosis, and diagnostic plan. Compendium on Continuing Education for the Practicing Veterinary, 22, 252-258.
    3. Bernard S.L., Leathers C.W., Brobst D.F., Gorham J.R. (1983): Estrogen - induced bone marrow depression in ferrets. American Journal of Veterinary Research, 44, 657-661.
    4. Besso J.G., Tidwell A.S., Gliatto J.M. (2000): Retrospective review of the ultrasonographic features of adrenal lesions in 21 ferrets. Veterinary Radiology and Ultrasound, 41, 345-352. Go to original source... Go to PubMed...
    5. Brown s.a. (1997): Basic anatomy, physiology, and husbandry, 3-13. In: Hillyer E.V., Quesenberry K.E. (eds.): Ferrets, Rabbits, and Rodents: Clinical Medicine and Surgery. W.B. Saunders, Philadelphia. 432 pp.
    6. Cooper J.E. (1985): Ferrets, 93-98. In: Cooper J.E., Hutchison M.F., Jackson O.F., Maurice R.J. (eds.): Manual of Exotic Pets. BSAVA, London. 312 pp.
    7. Fox J.G., Marini R.P. (1998): Diseases of the endocrine system. In: Fox J.G. (ed.): Biology and Diseases of the Ferret. 2nd ed. Williams' Wilkins, Baltimore. 291-305.
    8. Fox J.G., Goad M.E.P., Garibaldi B.A., Wiest L.M. (1987): Hyperadrenocorticism in a ferret. Journal of the American Veterinary Medical Association, 191, 343-344.
    9. Jekl V., Hauptman K., Jeklova E., Knotek Z. (2005): Blood sampling from the cranial vena cava in the Norway rat (Rattus norvegicus). Laboratory Animals, 39, 236- 239. Go to original source... Go to PubMed...
    10. Kelleher S.A. (2001): Skin diseases of ferrets. The Veterinary Clinics of North America. Exotic Animal Practice, Dermatology, 4, 565-572. Go to original source... Go to PubMed...
    11. Kociba G.J., Caputo Ch.A. (1981): Aplastic anemia associated with estrus in pet ferrets. Journal of the American Veterinary Medical Association, 178, 1293- 1294.
    12. Lawrence H.L., Goudl W.J., Flanders J.A., Yeager A.E. (1993): Unilateral adrenalectomy as a treatment for adrenocortical tumors in ferrets: five cases (1990- 1992). Journal of the American Veterinary Medical Association, 203, 267-270. Go to original source...
    13. Li X., Fox J.G. (1996): Neoplastic diseases. In: Fox J.G. (ed.): Biology and Diseases of the Ferret. 2nd ed. Williams' Wilkins, Baltimore. 568 pp.
    14. Lloyd M. (1999): Dermatologic diseases, 78-87. In: Lloyd M. (ed.): Ferrets Health, Husbandry and Diseases. Blackwell Science Ltd., Oxford. 198 pp.
    15. Neuwirth L., Isaza R., Bellah J., Ackerman N., Collins B. (1993): Adrenal neoplasia in seven ferrets. Veterinary Radiology and Ultrasound, 34, 340-346. Go to original source...
    16. O'Brien R., Paul-Murphy J., Dubielzig R.R. (1996): Ultrasonography of adrenal glands in normal ferrets. Veterinary Radiology and Ultrasound, 37, 445-448. Go to original source...
    17. Pearson R.C. (1999): The ferret, 137-144. In: Quimby F.W., Loeb V.F. (eds.): The Clinical Chemistry of Laboratory Animals. 2nd ed. Taylor and Francis, Philadelphia. 753 pp.
    18. Pollock C.G. (2003): Endocrine diseases. In: Quesenberry K.E., Carpenter J.W. (ed.): Ferrets, Rabbits and Rodents. Clinical Medicine and Surgery. 2nd ed. W.B. Saunders, St. Louis. 79-90. Go to original source...
    19. Prohaczik A., Kulcsar M., Huszenicza G. (2009a): Deslorelin treatment of hyperoestrogenism in neutered ferrets (Mustela putorius furo): a case report. Veterinarni Medicina, 54, 89-95. Go to original source...
    20. Prohaczik A., Kulcsar M., Huszenicza G. (2009b): Metabolic and endocrine characteristics of pregnancy toxemia in the ferret. Veterinarni Medicina, 54, 75-80. Go to original source...
    21. Rosenthal K.L. (1997): Adrenal gland disease in ferrets. The Veterinary Clinics of North America, Exotic Animal Practice, 27, 401-417. Go to original source... Go to PubMed...
    22. Rosenthal K.L., Peterson M.E. (1996): Stranguria in a castrated male ferret. Journal of the American Veterinary Medical Association, 209, 62-64. Go to original source...
    23. Rosenthal K.L., Peterson M.E., Quesenberry K.E., Lothrop C.D. (1993): Evaluation of plasma cortisol and corticosterone responses to synthetic adrenocorticotropic hormone administration in ferrets. American Journal of Veterinary Research, 54, 29-31. Go to original source...
    24. Ryland L.M. (1982): Remission of estrus - associated anemia following ovariohysterectomy andmultiple blood transfusions in a ferret. Journal of the American Veterinary Medical Association, 181, 820-822.
    25. Schoemaker N.J., Teerds K.J., Mol J.A., Lumeij J.T., Thijssen J.H.H., Rijnberk A., (2002): The role of luteinizing hormone in the pathogenesis of hyperadrenocorticism in neutered ferrets. Molecular and Cellular Endocrinology, 197, 117-125. Go to original source... Go to PubMed...
    26. Sherill A., Gorham J.R. (1985): Bone marrow hypoplasia associated with estrus in ferret. Laboratory Animal Science, 35, 280-286.
    27. Wagner R.A., Dorn D.P. (1994): Evaluation of serum estradiol concentrations in alopecic ferrets with adrenal gland tumors. Journal of the American Veterinary Medicine Association, 205, 703-707. Go to original source...

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