Vet Med - Czech, 2013, 58(1):1-9 | DOI: 10.17221/6650-VETMED

Structural homology and expression tendency of the natural immune response of the terminal complement components to inoculations in pigs: a reviewReview

D.V.A. Khoa
College of Agriculture and Applied Biology, Can Tho University, Vietnam

The transmission of infectious agents from domestic animals to humans is a matter of particular concern at present. Inoculation can enhance the defences of each individual animal but only in the short term. Certainly, it will be of immense benefit if biotechnology and genetic techniques are applied to farm animal breeding and selection programs to improve productivity, performance and health status as well as for the construction of sustainable animal production systems and promotion of animal welfare. In recent years, efforts to drive candidate genes like cytokines, haptoglobin, complement system, C-reactive protein, a 2-macroglobulin, retinol binding protein, transcortin, and etc. associated with immune traits have successfully been studied in human and different animal species. Here, we compared the molecular structure and evaluated the expression tendency of the haemolytic complement activity (HCA) of porcine candidate genes encoding the terminal complement components (TCC) C6-9. The results suggested that (1) high homology of complement genes among mammalian species may open new ways in cure/ treatment of disease; (2) Muong Khuong animals (Vietnamese potbelly pig) have a great genetic potential to improve the health status of pigs; and (3) HCA in the classical pathway can be developed further by different activation modes, with the potential improvement of animal health.

Keywords: pigs; terminal complement genes; homology; genetic variation; and haemolytic complement activity

Published: January 31, 2013  Show citation

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Khoa DVA. Structural homology and expression tendency of the natural immune response of the terminal complement components to inoculations in pigs: a review. Vet Med - Czech. 2013;58(1):1-9. doi: 10.17221/6650-VETMED.
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    References

    1. Alberti S, Marques G, Hernandez-Alles S, Rubires X, Tomas JM, Vivanco F, Benedi VJ (1996): Interaction between complement subcomponent C1q and the Klebsiella pneumoniae porin OmpK36. Infection and Immunity 64, 4719-4725. Go to original source... Go to PubMed...
    2. Bredt W, Wellek B, Brunner H, Loos M (1977): Interactions between mycoplasma pneumoniae and the first components of complement. Infection and Immunity 15, 7-12. Go to original source... Go to PubMed...
    3. Castell JV, Gomezlechon MJ, David M, Andus T, Geiger T, Trullenque R, Fabra R, Heinrich PC (1989): Interleukin-6 is the major regulator of acute phase protein-synthesis in adult human hepatocytes. FEBS Letters 242, 237-239. Go to original source... Go to PubMed...
    4. Clark LK, Armstrong CH, Freeman MJ, Scheidt AB, Sandsfreeman L, Knox K (1991): Investigating the transmission of mycoplasma-hyopneumoniae in a swine herd with enzootic pneumonia. Veterinary Medicine (US) 86, 543-550.
    5. Dewald G, Cichon S, Bryant SP, Hemmer S, Nothen MM, Spurr NK (1996): The human complement C8G gene, a member of the lipocalin gene family: Polymorphisms and mapping to chromosome 9q34.3. Annals of Human Genetics 60, 281-291. Go to original source... Go to PubMed...
    6. DiScipio RG, Linton SM, Rushmere NK (1999): Function of the factor I modules (FIMS) of human complement component C6. Journal of Biological Chemistry 274, 31811-31818. Go to original source... Go to PubMed...
    7. Durandy A (2003): Ontogeny of the immune system. Transfusion Medicine and Hemotherapy 30, 222-227. Go to original source...
    8. Eisenschenk FC, Houle JJ, Hoffmann EM (1999): Mechanism of serum resistance among Brucella abortus isolates. Veterinary Microbiology 68, 235-244. Go to original source... Go to PubMed...
    9. Eng RHK (1980): Bactericidal screening test for late complement component deficiencies or defects. Journal of Clinical Microbiology 11, 631-634. Go to original source... Go to PubMed...
    10. Esser AF (1994): The membrane attack complex of complement: assembly, structure and cytotoxic activity. Toxicology 87, 229-247. Go to original source... Go to PubMed...
    11. Flo TH, Smith KD, Sato S, Rodriguez DJ, Holmes MA, Strong RK, Akira S, Aderem A (2004): Lipocalin 2 mediates an innate immune response to bacterial infection by sequestrating iron. Nature 432, 917-921. Go to original source... Go to PubMed...
    12. Fukumori Y, Horiuchi T (1998): Terminal complement component deficiencies in Japan. Experimental and Clinical Immunogenetics 15, 244-248. Go to original source... Go to PubMed...
    13. Gonzalez-Ramon N, Hoebe K, Alava MA, van Leengoed L, Pineiro M, Carmona S, Iturralde M, Lampreave F, Pineiro A (2000): Pig MAP/ITIH4 and haptoglobin are interleukin-6-dependent acute-phase plasma proteins in porcine primary cultured hepatocytes. European Journal of Biochemistry 267, 1878-1885. Go to original source... Go to PubMed...
    14. Goundis D, Reid KBM (1988): Properdin, the terminal complement components, thrombospondin and the circumsporozoite protein of malaria parasites contain similar sequence motifs. Nature 335, 82-85. Go to original source... Go to PubMed...
    15. Haeney MR, Thompson RA, Faulkner J, Mackintosh P, Ball AP (1980): Recurrent bacterial-meningitis in patients with genetic-defects of terminal complement components. Clinical and Experimental Immunology 40, 16-24. Go to PubMed...
    16. Haesebrouck F, Pasmans F, Chiers K, Maes D, Ducatelle R, Decostere A (2004): Efficacy of vaccines against bacterial diseases in swine: what can we expect? Veterinary Microbiology 100, 255-268. Go to original source... Go to PubMed...
    17. Henryon M, Juul-Madsen HR, Berg P (2002): Genetic variation for total and differential numbers of leukocytes in growing pigs. In: Proceedings of the 7th World Congress on Genetics Applied to Livestock Production, INRA, August 19-23, Montpellier, France.
    18. Inai S, Akagaki Y, Moriyama T, Fukumori Y, Yoshimura K, Ohnoki S, Yamaguchi H (1989): Inherited deficiencies of the late-acting complement components other than c9 found among healthy blood-donors. International Archives of Allergy and Applied Immunology 90, 274-279. Go to original source... Go to PubMed...
    19. Jiang H, Siegel JN, Gewurz H (1991): Binding and complement activation by C-reactive protein via the collagen-like region of C1q and inhibition of these reactions by monoclonal antibodies to C-reactive protein and C1q. Journal of Immunology 146, 2324-2330. Go to original source... Go to PubMed...
    20. Khoa DVA (2010): Porcine Terminal Complement Genes C6-9: Molecular Characterization of Terminal Complement Genes and their Association With Hemolytic Complement Activity in Pigs. VDM Verlag Dr. Müller Publisher. ISBN-10 3836494019, ISBN-13 978-3-83649401-4, ASIN: 3836494019. Berlin, Germany.
    21. Komatsu M, Yoshiwara S, Akita T (1998): Immunological characteristics of the Meishan pig: serum complement activity, serum C3 level, immune response and skin structure. In: Proceedings of the 6th World Congress on Genetics Applied to Livestock Production. Armidale, NSW, Australia, 323-326. Go to original source...
    22. Kumar KG, Ponsuksili S, Schellander K, Wimmers K (2004): Molecular cloning and sequencing of porcine C5 gene and its association with immunological traits. Immunogenetics 55, 811-817. Go to original source... Go to PubMed...
    23. Loos M, Clas F (1987): Antibody-independent killing of gram-negative bacteria via the classical pathway of complement. Immunological Letters 14, 203-208. Go to original source... Go to PubMed...
    24. Loos M, Brunner H (1979): Complement components (C1, C2, C3, C4) in bronchial secretions after intranasal infection of guinea pigs with Mycoplasma pneumoniae: dissociation of unspecific and specific defense mechanisms. Infection and Immunity 25, 583-585. Go to original source... Go to PubMed...
    25. Mackiewicz A, Ganapathi MK, Schultz D, Brabenec A, Weinstein J, Kelley MF, Kushner I (1990): Transforming growth factor-beta-1 regulates production of acute-phase proteins. Proceedings of the National Academy of Sciences of the United States of America 87, 1491-1495. Go to original source... Go to PubMed...
    26. Mallard BA, Wilkie BN, Kennedy BW, Gibson J, Quinton M (1998): Immune responsiveness in swine: eight generations of selection for high and low immune response in Yorkshire pigs. In: Proceedings of the 6th World Congress on Genetics Applied to Livestock Production. University of New England, Armidale, New South Wales, Australia, 257-264.
    27. McCloskey MA, Dankert JR, Esser AF (1989): Assembly of complement components C5b-8 and C5b-9 on lipid bilayer membranes: visualization by freeze-etch electron microscopy. Biochemistry 28, 534-540. Go to original source... Go to PubMed...
    28. Merino S, Nogueras MM, Aguilar A (1998): Activation of the complement classical pathway (C1q binding) by mesophilic Aeromonas hydrophila outer membrane protein. Infection and Immunity 66, 3825-3831. Go to original source... Go to PubMed...
    29. Minion FC (2002): Molecular pathogenesis of mycoplasma animal respiratory pathogens. Frontiers in Bioscience 7, 1410-1422. Go to original source...
    30. Mold C (1998): Cellular responses to the membrane attack complex. In: Volanakis JE, Frank MM (eds.): The Human Complement System in Health and Disease. Marcel Dekker, New York. 309-325. Go to original source...
    31. Mold C, Gewurz H, Du Clos TW (1999): Regulation of complement activation by C-reactive protein. Immunopharmacology 42, 23-30. Go to original source... Go to PubMed...
    32. Monahan JB, Sodetz JM (1980): Binding of the eighth component of human complement to the soluble cytolytic complex is mediated by its beta subunit. Journal of Biological Chemistry 255, 10579-10582. Go to original source...
    33. Morgan BP (1999): Regulation of the complement membrane attack pathway. Critical Reviews in Immunology 19, 173-198. Go to original source... Go to PubMed...
    34. Morrison DC, Kline LF (1977): Activation of the classical and properdin pathways of complement by bacterial lipopolysaccharides (LPS). Journal of Immunology 118, 362-368. Go to original source... Go to PubMed...
    35. Musingarimi P, Plumb ME, Sodetz JM (2002): Interaction between the C8 alpha-gamma and C8 beta subunits of human complement C8: role of the C8 beta N-terminal thrombospondin type 1 module and membrane attack complex/perforin domain. Biochemistry 41, 11255-11260. Go to original source... Go to PubMed...
    36. O'Leary JM, Bromek K, Black GM, Uhrinova S, Schmitz C, Wang XF, Krych M, Atkinson JP, Uhrin D, Barlow PN (2004): Backbone dynamics of complement control protein (CCP) modules reveals mobility in binding surfaces. Protein Science 13, 1238-1250. Go to original source... Go to PubMed...
    37. Olaho-Mukani W, Nyang'ao JNM, Kimani JK, Omuse JK (1995): Studies on the haemolytic complement of the dromedary camel (Camelus dromedarius). I. Classical pathway haemolytic activity in serum. Veterinary Immunology and Immunopathology 46, 337-347. Go to original source... Go to PubMed...
    38. Peake PW, Shen Y, Walther A, Charlesworth JA (2008): Adiponectin binds C1q and activates the classical pathway of complement. Biochemical and Biophysical Research Communication 367, 560-565. Go to original source... Go to PubMed...
    39. Parker CL, Sodetz JM (2002): Role of the human C8 subunits in the complement-mediated bacterial killing: evidence that C8 gamma is not essential. Molecular Immunology 39, 453-458. Go to original source... Go to PubMed...
    40. Petry DB, Holl JW, Weber JS, Doster AR, Osorio FA, Johnson RK (2005): Biological responses to porcine respiratory and reproductive syndrome virus in pigs of two genetic populations. Journal of Animal Science 83, 1494-1502. Go to original source... Go to PubMed...
    41. Phatsara C, Jennen DGJ, Ponsuksili S, Murani E, Tesfaye D, Schellander K, Wimmers K (2007): Molecular genetic analysis of porcine mannose-binding lectin genes, MBL1 and MBL2, and their association with complement activity. International Journal of Immunogenetics 34, 55-63. Go to original source... Go to PubMed...
    42. Platteborze PL, Hobart MJ, Sodetz JM (1996): Physical linkage and orientation of the human complement C8a and C8ß genes on chromosome 1p32. Human Genetics 98, 443-446. Go to original source... Go to PubMed...
    43. Rao AG, Sodetz JM (1984): Purification of functional subunits of the eighth component of human complement (C8) under nondenaturing conditions. Complement 1, 182-186. Go to original source... Go to PubMed...
    44. Rosado CJ, Buckle AM, Law RHP, Butcher RE, Kan WT, Bird CH, Ung K, Browne KA, Baran K, BashtannykPuhalovich TA, Faux NG, Wong W, Porter CJ, Pike RN, Ellisdon AM, Pearce MC, Bottomley SP, Emsley J, Smith AI, Rossjohn J, Hartland EL, Voskoboinik I, Trapani JA, Bird PI, Dunstone MA, Whisstock JC (2007): A common fold mediates vertebrate defense and bacterial attack. Science 317, 1548-1551. Go to original source... Go to PubMed...
    45. Ross SC, Densen P (1984): Complement deficiency states and infection: epidemiology, pathogenesis and consequences of neisserial and other infections in an immune deficiency. Medicine (Baltimore) 63, 243-273. Go to original source... Go to PubMed...
    46. Schreck SF, Plumb ME, Platteborze PL, Kaufman KM, Michelotti GA, Letson CS, Sodetz JM (1998): Expression and characterization of recombinant subunits of human complement component C8: Further analysis of the function of C8 alpha and C8 gamma. Journal of Immunology 161, 311-318. Go to original source... Go to PubMed...
    47. Schreck SF, Parker C, Plumb ME, Sodetz JM (2000): Human complement protein C8G. Biochimimica et Biophysica Acta 1482, 199-208. Go to original source... Go to PubMed...
    48. Schreiber RD, Morrison DC, Podack ER, Mueller-Eberhard HJ (1979): Bactericidal activity of the alternative complement pathway generated from 11 isolated plasma proteins. Journal of Experimental Medicine 149, 870-882. Go to original source... Go to PubMed...
    49. Scolding NJ, Morgan BP, Compston DA (1998): The expression of complement regulatory proteins by adult human oligodendrocytes. Journal of Neuroimmunology 84, 69-75. Go to original source... Go to PubMed...
    50. Slade DJ, Chiswell B, Sodetz JM (2006): Functional studies of the MACPF domain of human complement protein C8alpha reveal sites for simultaneous binding of C8beta, C8gamma, and C9. Biochemistry 45, 5290-5296. Go to original source... Go to PubMed...
    51. Thai CT, Ogata RT (2005): Recombinant C345C and factor I modules of complement components C5 and C7 inhibit C7 incorporation into the complement membrane attack complex. Journal of Immunology 174, 6227-6232. Go to original source... Go to PubMed...
    52. Tschopp J (1984): Ultrastructure of the membrane attack complex of complement. Heterogeneity of the complex caused by different degree of C9 polymerization. Journal of Biological Chemistry 259, 7857-7863. Go to original source...
    53. Tschopp J, Masson D, Stanley KK (1986): Structural/ functional similarity between proteins involved in complement- and cytotoxic T-lymphocyte-mediated cytolysis. Nature 322, 831-834. Go to original source... Go to PubMed...
    54. Tyler JW, Cullor JS, Osburn BI, Parker K (1988): Agerelated variations in serum concentrations of the third component of complement in swine. Americal Journal of Veterinary Research 49, 1104-1106.
    55. Vazquez-Bermudez MF, Barroso S, Walter K, Alvarez AJ, Alarcon A, Lopez-Trascasa M, Wichmann I, Aguilar F, Nunez-Roldan A, Sanchez B (2003): Complement component C7 deficiency in a Spanish family. Clinical and Experimental Immunology 133, 240-246. Go to original source... Go to PubMed...
    56. Vissher AH, Janss LL, Niewold TA, de Greef KH (2002): Disease incidence and immunological traits for the selection of healthy pigs. A review. Veterinary Quarterly 24, 29-34. Go to original source... Go to PubMed...
    57. Wilkie B, Mallard B (1999): Selection for high immune response: an alternative approach to animal health maintenance? Veterinary Immunology and Immunopathology 72, 231-235. Go to original source... Go to PubMed...
    58. Wimmers K, Mekchay S, Schellander K, Ponsuksili S (2003): Molecular characterization of the pig C3 gene and its association with complement activity. Immunogenetics 54, 714-724. Go to original source... Go to PubMed...
    59. Yonemasu K, Kitajima H, Tanabe S, Ochi T, Shinkai H (1978): Effect of age on C1Q and C3 levels in humanserum and their presence in colostrum. Immunology 35, 523-530. Go to PubMed...
    60. Zhu ZB, Atkinson TP, Hovanky KT, Boppana SB, Dai YL, Densen P, Go RCP, Jablecki JS, Volanakis JE (2000): High prevalence of complement component C6 deficiency among African-Americans in the South-eastern USA. Clinical and Experimental Immunology 119, 305-310. Go to original source... Go to PubMed...

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