Vet Med - Czech, 2016, 61(8):413-420 | DOI: 10.17221/20/2016-VETMED

Effects of erythromycin on milk yield, rumen contraction rate and blood beta-hydroxybutyrate concentration in dairy cows after laparoscopic reposition of the left displaced abomasumOriginal Paper

M. Freick1, J. Weber1, O. Passarge1, S.D. Kevork2
1 Veterinary Practice Zettlitz, Zettlitz OT Methau, Germany
2 Statistical Consulting Unit StaBLaB, Munich, Germany

The objective of this study was to evaluate the beneficial effects of erythromycin (Emy), a prokinetic drug active at the level of the abomasum, duodenum and proximal duodenum, in dairy cows undergoing a laparoscopic repositioning of left abomasal displacement (LAD). A total of 71 German Holstein cows were randomly assigned into three groups. Cows of the group Emy1 received erythromycin once preoperatively (10 mg/kg; intramuscularly). Animals of the group Emy3 were additionally treated twice after surgery at intervals of 24 h each (10 mg/kg; intramuscularly), while cows in the control group did not receive erythromycin. The milk yield of the patients was documented on Days 0, 1, 2, 3, 6 and 10 and the rumen contraction rate (RCR) was determined on Days 1 and 3. Additionally, the measurement of the concentration of beta-hydroxybutyrate (BHB) in whole blood samples was performed on Days 0, 1 and 3. Significant differences between the study groups regarding the cure rates, milk yield (in relation to Day 0); BHB concentrations and RCR could not be determined on the observation dates. With respect to a prudent use of antibiotics in livestock, the application of erythromycin as a prokinetic drug cannot be recommended for the present in cows undergoing a laparoscopic correction of LAD.

Keywords: cattle; dislocatio abomasi; endoscopy; prokinetic drugs; gastrointestinal mobility

Published: August 31, 2016  Show citation

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Freick M, Weber J, Passarge O, Kevork SD. Effects of erythromycin on milk yield, rumen contraction rate and blood beta-hydroxybutyrate concentration in dairy cows after laparoscopic reposition of the left displaced abomasum. Vet Med - Czech. 2016;61(8):413-420. doi: 10.17221/20/2016-VETMED.
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    References

    1. Afshari GR, Nouri M, Hassan EB, Mokhber-Dezfooli MR, Constable PD (2009): Effect of parenteral administration of ivermectin and erythromycin on abomasal emptying rate in suckling calves. American Journal of Veterinary Research 70, 527-531. Go to original source... Go to PubMed...
    2. Barisani C (2004): Advancement of the Janowitz technique for replacement of the left displaced abomasum by Barisani (in Italian). Summa 15, 35-39.
    3. Christiansen K (2004): Laparoscopic operation for left displaced abomasum (Janowitz operation) for ruminants in a standing position (in German). Tierarztliche Praxis G 32, 118-121. Go to original source...
    4. Constable PD, Nouri M, Sen I, Baird AN, Wittek T (2012): Evidence-based use of prokinetic drugs for abomasal disorders in cattle. Veterinary Clinics of North America Food Animal Practice 28, 51-70. Go to original source... Go to PubMed...
    5. Dhir R, Richter JE (2004): Erythromycin in the short- and long-term control of dyspepsia symptoms in patients with gastroparesis. Journal of Clinical Gastroenterology 38, 237-242. Go to original source... Go to PubMed...
    6. Dirksen G (1990): Digestive system. In: Rosenberger G (ed.): The Clinical Examination in Cattle (in German). 3rd edn. Parey, Hamburg, Germany. 288-400.
    7. Dirksen G (2006): Ileus in cattle. In: Rosenberger G (ed.): The Clinical Examination in Cattle (in German). 3rd edn. Parey, Hamburg, Germany. 514-517.
    8. Freick M, Sieber I, Endtmann A, Passarge U, Passarge O (2013): Laparoscopic reposition of the displaced abomasum in a dairy herd in Saxony/Germany - a case series (in German). Tierarztliche Umschau 68, 311-321.
    9. Geishauser T, Leslie K, Duffield T (2000): Metabolic aspects in the etiology of displaced abomasum. Veterinary Clinics of North America Food Animal Practice 16, 255-265. Go to original source... Go to PubMed...
    10. Grosche A, Furll M, Wittek T (2012): Peritoneal fluid analysis in dairy cows with left displaced abomasum and abomasal volvulus. Veterinary Record 170, 413. Go to original source... Go to PubMed...
    11. Guglielmini C (2001): Use of flunixin meglumine in cattle with left abomasal displacement (in Italian). Atti della Societa Italiana Buiatria 33, 269-273.
    12. Iwersen M, Klein-Jobstl D, Pichler M, Roland L, Fidlschuster B, Schwendenwein I, Drillich M (2013): Comparison of 2 electronic cowside tests to detect subclinical ketosis in dairy cows and the influence of the temperature and type of blood sample on the test results. Journal of Dairy Science 96, 7719-7730. Go to original source... Go to PubMed...
    13. Janowitz H (1998): Laparoscopic reposition and fixation of the left displaced abomasum in cattle (in German). Tierarztliche Praxis G 26, 308-313.
    14. Klevenhusen F, Humer E, Metzler-Zebeli B, PodstatzkyLichtenstein L, Wittek T, Zebeli Q (2015): Metabolic profile and inflammatory responses in dairy cows with left displaced abomasum kept under small-scaled farm conditions. Animals (Basel) 5, 1021-1033. Go to original source... Go to PubMed...
    15. Kotter R (2005): Treatment of cows with left abomasal displacement by laparoscopic abomasopexy according to Janowitz - a field study (in German). [Doctoral Thesis.] University of Veterinary Medicine Hannover, Foundation, Germany.
    16. Kroker R (2010): Pharmaceuticals for treatment and prevention of bacterial infections (in German). In: Loscher W, Ungemach FR, Kroker R (eds): Pharmacotherapy in Companion Animals and Livestock (in German). 8th edn. Enke, Stuttgart, Germany. 249-297.
    17. Kusenda M, Kaske M, Piechotta M, Locher L, Starke A, Huber K, Rehage J (2013): Effects of dexamethasone21-isonicotinate on peripheral insulin action in dairy cows 5 days after surgical correction of abomasal displacement. Journal of Veterinary Internal Medicine 27, 200-206. Go to original source... Go to PubMed...
    18. Loptien A, Loschner U, Staufenbiel R (2005): Cross-sectional study of occurrence and treatment success of abomasum displacement with respect to surgical approach (in German). Tierarztliche Praxis G 33, 419-426. Go to original source...
    19. Loscher W (2010): Pharmaceuticals with effects in the central nervous system. In: Loscher W, Ungemach FR, Kroker R (eds): Pharmacotherapy in Companion Animals and Livestock (in German). 8th edn. Enke, Stuttgart, Germany. 64-133.
    20. Newby NC, Pearl DL, LeBlanc SJ, Leslie KE, von Keyserlingk MA, Duffield TF (2013): The effect of administering ketoprofen on the physiology and behavior of dairy cows following surgery to correct a left displaced abomasum. Journal of Dairy Science 96, 1511-1520. Go to original source... Go to PubMed...
    21. Pairet M, Ruckebusch Y (1989): On the relevance of nonsteroidal anti-inflammatory drugs in the prevention of paralytic ileus in rodents. Journal of Pharmacy and Pharmacology 41, 757-761. Go to original source... Go to PubMed...
    22. R Core Team (2014): R: A language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria, 2014. Available: URL http://www.R-project.org/ (Accessed 1 November 2015).
    23. Reynen JL, Kelton DF, LeBlanc SJ, Newby NC, Duffield TF (2015): Factors associated with survival in the herd for dairy cows following surgery to correct left displaced abomasum. Journal of Dairy Science 98, 3806-3813. Go to original source... Go to PubMed...
    24. Sanger GJ, Wang Y, Hobson A, Broad J (2013): Motilin: towards a new understanding of the gastrointestinal neuropharmacology and therapeutic use of motilin receptor agonists. British Journal of Pharmacology 170, 1323- 1332. Go to original source... Go to PubMed...
    25. Sattler T, Wittek T (2011): Reposition of displaced abomasum - an overview (in German). Praktischer Tierarzt 92, 900-910.
    26. Schwarz NT, Kalff JC, Turler A, Engel BM, Watkins SC, Billiar TR, Bauer AJ (2001): Prostanoid production via COX-2 as causative mechanisms of rodent postoperative ileus. Gastroenterology 121, 1354-1371. Go to original source... Go to PubMed...
    27. Staufenbiel R (1998): Approaches to prevent abomasal displacement. In: Furll M (ed.): Etiology, Pathogenesis, Diagnostics, Prognosis, Therapy and Prevention of Abomasal Displacement (in German). Proceedings of the International Workshop, Leipzig, Germany. 291-309.
    28. Steinbrook RA (1998): Epidural anesthesia and gastrointestinal motility. Anesthesia and Analgesia 86, 837-844. Go to original source... Go to PubMed...
    29. Suthar VS, Canelas-Raposo J, Deniz A, Heuwieser W (2013): Prevalence of subclinical ketosis and relationships with postpartum diseases in European dairy cows. Journal of Dairy Science 96, 2925-2938. Go to original source... Go to PubMed...
    30. Swinkels JM, Hilkens A, Zoche-Golob V, Kromker V, Buddiger M, Jansen J, Lam TJ (2015): Social influences on the duration of antibiotic treatment of clinical mastitis in dairy cows. Journal of Dairy Science 98, 2369-2380. Go to original source... Go to PubMed...
    31. Thabit AK, Crandon JL, Nicolau DP (2015): Antimicrobial resistance: impact on clinical and economic outcomes and the need for new antimicrobials. Expert Opinion on Pharmakotherapy 16, 159-177. Go to original source... Go to PubMed...
    32. Ungemach FR (2010): Pharmaceuticals with effects in the gastrointestinal tract. In: Loscher W, Ungemach FR, Kroker R (eds): Pharmacotherapy in Companion Animals and Livestock (in German). 8th edn. Enke, Stuttgart, Germany. 217-243.
    33. Vickers AJ, Altman DG (2001): Analysing controlled trials with baseline and follow up measurements. British Medical Journal 323, 1123-1124. Go to original source... Go to PubMed...
    34. Virolainen N, Karp M (2014): Biosensors, antibiotics and food. Advances in Biochemical Engineering/Biotechnology 145, 153-185. Go to original source... Go to PubMed...
    35. Wickham H (ed.) (2009): ggplot2: Elegant Graphics for Data Analysis. Springer, New York, USA. 213 pp. Go to original source...
    36. Wittek T (2010): A review on stimulation of abomasal motility and emptying after surgical correction of left displaced abomasum or abomasal volvolus (in German). Praktischer Tierarzt 91, 892-898.
    37. Wittek T, Schreiber K, Furll M, Constable PD (2005): Use of the D-xylose absorption test to measure abomasal emptying rate in healthy lactating Holstein-Friesian cows and in cows with left displaced abomasum or abomasal volvulus. Journal of Veterinary Internal Medicine 19, 905-913. Go to original source...
    38. Wittek T, Tischer K, Gieseler T, Furll M, Constable PD (2008a): Effect of preoperative administration of erythromycin or flunixin meglumine on postoperative abomasal emptying rate in dairy cows undergoing surgical correction of left displacement of the abomasum. Journal of the American Veterinary Medical Association 232, 418-423. Go to original source... Go to PubMed...
    39. Wittek T, Tischer K, Korner I, Sattler T, Constable PD, Furll M (2008b): Effect of preoperative erythromycin or dexamethasone/vitamin C on postoperative abomasal emptying rate in dairy cows undergoing surgical correction of abomasal volvulus. Veterinary Surgery 37, 537-544. Go to original source... Go to PubMed...
    40. Wittek T, Locher LF, Alkaassem A, Constable PD (2009): Effect of surgical correction of left displaced abomasum by means of omentopexy via right flank laparotomy or two-step laparoscopy-guided abomasopexy on postoperative abomasal emptying rate in lactating dairy cows. Journal of the American Veterinary Medical Association 234, 652-657. Go to original source... Go to PubMed...
    41. Wittek T, Furll M, Grosche A (2012): Peritoneal inflammatory response to surgical correction of left displaced abomasum using different techniques. Veterinary Record 171, 594. Go to original source... Go to PubMed...

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