Veterinární medicína, 2020 (vol. 65), issue 2

Ultrasound-guided removal of soft tissue foreign bodies in companion animals: A case seriesOriginal Paper

S Manfredi, G Covi, M Bonazzi, G Gnudi, M Fumeo, F Miduri, E Daga, A Volta

Vet Med - Czech, 2020, 65(2):49-55 | DOI: 10.17221/18/2019-VETMED  

Foreign bodies (FBs) retained in the subcutaneous tissues are a common reason for medical consultation. In small animals, FBs usually consist of vegetal materials, especially grass awns. Failure to remove the FBs is likely to give rise to acute or late complications. The surgical removal of the FBs can be invasive, costly and technically challenging. Ultrasound has become a mainstay in the detection of FBs and it can be used to guide the extraction of the FBs with a minimally invasive technique. This study describes the detection and extraction of soft-tissue FBs in small animals. One hundred-sixty-two patients, presenting at two veterinary clinics...

Comparison of the cytotoxic effects of single and divided treatment of 4-hydroxycyclophosphamide at the same total dosage amount in canine lymphoma cell linesOriginal Paper

AT Liao, YC Chen, SL Wang

Vet Med - Czech, 2020, 65(2):56-61 | DOI: 10.17221/86/2019-VETMED  

Cyclophosphamide is widely used in combination chemotherapy to treat dogs with lymphoma. The metabolite of cyclophosphamide, acrolein, can irritate the urinary bladder and cause sterile haemorrhagic cystitis. The divided administration of cyclophosphamide across multiple days may reduce the occurrence of the cystitis. However, the therapeutic effect of this modification has not been evaluated and compared to the traditional single maximum-tolerated dose. It is difficult to evaluate the cytotoxic effect by the single chemotherapeutic drug in dogs. In order to verify the effect of the single and divided treatment of cyclophosphamide in canine lymphoma,...

Effect of intra-articular administration of autologous PRP and activated PRP on inflammatory mediators in dogs with osteoarthritisOriginal Paper

K Parlak, M Arican

Vet Med - Czech, 2020, 65(2):62-70 | DOI: 10.17221/36/2019-VETMED  

The aim of this study was to investigate the effects of the intra-articular use of platelet rich plasma (PRP) and bio-physically activated PRP (BPRP) on the inflammatory mediators for the treatment of osteoarthritis in dogs. The animals included in this study were 36 mix breed dogs diagnosed with osteoarthritis in the stifle as a result of the clinical and radiological examinations. The dogs were randomly divided into three groups: PRP (platelet-rich plasma), BPRP (biophysically activated platelet-rich plasma) and control (given 0.9% isotonic saline). These three main groups were each further divided into two groups as single and double according to...

Co-administration of vitamin E and selenium in vivo and in vitro ameliorates the toxic effects caused by ivermection and doramectinOriginal Paper

AE Ahmed, MA Al-Kahtani, AM Khalil, AS Alshehri, AA Elghoneimy, ESI Elbehairi, MY Alfaifi, AA Shati, KS Morsy, MA Alshehri, HI El-Mekkawy, AA Elmansi

Vet Med - Czech, 2020, 65(2):71-83 | DOI: 10.17221/74/2019-VETMED  

Avermectins are used in animals and humans for their broad-spectrum effects against parasites causing cytotoxicity and damage to the cellular DNA. In this study, we examined the toxicological changes of ivermectin (IVM) and doramectin (DME) with or without the co-administration of vitamin E (Vit. E) and selenium (Se). The drugs used were for animal use. Twenty-five adult male rats were divided into five groups. Group 1 (control) was given saline, Group 2 was given IVM (0.2 mg/kg b.w.), Group 3 was given IVM and Vit. E/Se (80/1.6 mg/kg b.w., respectively), Group 4 received DME (0.2 mg/kg b.w.), and Group 5 received DME and Vitamin E/Se. Both IVM and...

Treatment of a feline cutaneous mast cell tumour using imatinib mesylate as a neoadjuvant tyrosine kinase inhibitor therapeutic agentCase Report

J Kim, HJ Kim

Vet Med - Czech, 2020, 65(2):84-88 | DOI: 10.17221/91/2019-VETMED  

A two-year-old spayed female American shorthair cat presented with a rough, circular, exophytic mass on the genital area. The clinical findings and histopathological examination revealed that the mass contained neoplastic mast cells and, thus, was diagnosed as a mast cell tumour. The anatomical location of the mass was not easily accessible for surgical intervention. We administered a targeted therapy using oral imatinib mesylate for eight weeks to reduce the size of the lesion and to facilitate the successful surgical removal. The tumour mass eventually reduced by 21% and was surgically excised. This is possibly the first study to use imatinib mesylate...

Balloon valvuloplasty in two dogs with aortic valve stenosis showing congestive heart failureCase Report

T Yoshida, K Matsuura, S Goya, D Ma, K Shimada, P Kitpipatkun, A Takeuchi, A Uemura, R Tanaka

Vet Med - Czech, 2020, 65(2):89-94 | DOI: 10.17221/154/2019-VETMED  

A 10-year-old female Papillon and a 1-year-old male Golden Retriever were presented to the Tokyo University of Agriculture and Technology for a second opinion on an aortic valve stenosis (AS). The aortic flow rate was not as high as it should have been (the aortic flow velocity for case 1 and case 2 was 2.82 m/s and 3.96 m/s, respectively). However, the AS was suspected to be an exacerbating factor in the congestive heart failure, so that a balloon valvuloplasty was conducted. As a result, the congestion and clinical symptoms were much improved in both cases. In conclusion, in cases with an AS, in which afterload is a key factor for the exacerbation...