Vet Med - Czech, 2020, 65(2):84-88 | DOI: 10.17221/91/2019-VETMED

Treatment of a feline cutaneous mast cell tumour using imatinib mesylate as a neoadjuvant tyrosine kinase inhibitor therapeutic agentCase Report

J Kim, HJ Kim
Department of Veterinary Internal Medicine, Chonnam National University, Yongbong-ro, Buk-gu, Gwangju, Republic of Korea

A two-year-old spayed female American shorthair cat presented with a rough, circular, exophytic mass on the genital area. The clinical findings and histopathological examination revealed that the mass contained neoplastic mast cells and, thus, was diagnosed as a mast cell tumour. The anatomical location of the mass was not easily accessible for surgical intervention. We administered a targeted therapy using oral imatinib mesylate for eight weeks to reduce the size of the lesion and to facilitate the successful surgical removal. The tumour mass eventually reduced by 21% and was surgically excised. This is possibly the first study to use imatinib mesylate as a tumour reduction neoadjuvant to therapeutically address a feline cutaneous mast cell tumour located in a surgically inaccessible part of the body.

Keywords: feline; mast cell tumour; chemotherapy; tyrosine kinase inhibitor

Received: July 15, 2019; Accepted: January 23, 2020; Published: February 29, 2020  Show citation

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Kim J, Kim H. Treatment of a feline cutaneous mast cell tumour using imatinib mesylate as a neoadjuvant tyrosine kinase inhibitor therapeutic agent. Vet Med - Czech. 2020;65(2):84-88. doi: 10.17221/91/2019-VETMED.
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