Vet Med - Czech, 2008, 53(3):169-172 | DOI: 10.17221/1938-VETMED

Nimesulide-induced acute biliary tract injury and renal failure in a kitten: a case report

M.K. Borku1, M. Guzel2, M.C. Karakurum3, K. Ural1, S. Aktas4
1 Faculty of Veterinary Medicine, Ankara University, Ankara, Turkey
2 Faculty of Veterinary Medicine, Mustafa Kemal University, Hatay, Turkey
3 Faculty of Veterinary Medicine, Mehmet Akif Ersoy University, Burdur, Turkey
4 Faculty of Veterinary Medicine, Ataturk University, Erzurum, Turkey

A 3-month-old male kitten was presented to our clinic with malaise, vomiting and jaundice. In the anamnesis, we learned that the cat had a history of anorexia, sneezing, and nasal discharge and that the owner had administered 100 mg/day (t.i.d.) nimesulide orally for three days. In the laboratory study, high levels of serum alkaline phosphatase, γ-glutamyl transtransferase, total bilirubin, direct bilirubin, indirect bilirubin, urea, and creatinine were detected. All the clinical signs and laboratory abnormalities returned to normal levels after cessation of the nimesulide and supportive treatment. In this case, clinical and laboratory findings were thought to be compatible with nimesulide-induced acute biliary injury and renal failure. This case report indicates that the household pets are at risk of toxic drugs administered by their owners and great caution should be taken in administering NSAIDs in cats.

Keywords: nonsteroidal anti-inflammatory drug; nimesulide; biliary injury; renal failure; kitten

Published: March 31, 2008  Show citation

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Borku MK, Guzel M, Karakurum MC, Ural K, Aktas S. Nimesulide-induced acute biliary tract injury and renal failure in a kitten: a case report. Vet Med - Czech. 2008;53(3):169-172. doi: 10.17221/1938-VETMED.
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    References

    1. Apostolou T., Sotsiou F., Yfanti G., Andreadis E., Nikolopoulou N., Diamantopoulos E., Billis A. (1997): Acute renal failure induced by nimesulide in a patient suffering from temporal arteritis. Nephrology Dialysis Transplantation, 12, 1493-1496. Go to original source... Go to PubMed...
    2. Balasubramaniam J. (2000): Nimesulide and neonatal renal failure. Lancet, 355, p. 575. Go to original source... Go to PubMed...
    3. Boelsterli U.A. (2002): Mechanisms of NSAIDs-induced hepatotoxicity: focus on nimesulide. Drug Safety, 25, 633-648. Go to original source... Go to PubMed...
    4. Gay G.R. (1990): Another side effect of NSAIDs. The Journal of the American Medical Association, 264, 2677-2678. Go to original source... Go to PubMed...
    5. Hawkey C.J. (1999): COX-2 inhibitors. Lancet, 353, 307-314. Go to original source... Go to PubMed...
    6. Jones R.D., Baynes R.E., Nimitz C.T. (1992): Nonsteroidal anti-inflammatory drug toxicosis in dogs and cats: 240 cases (1989-1990). Journal of the American Veterinary Medical Association, 201, 475-477. Go to original source... Go to PubMed...
    7. Lacroix I., Lapeyre-Mestre M., Bagheri H., Pathak A., Montastruc J.L. (2004): Nonsteroidal anti-inflammatory drug-induced liver injury: a case - control study in primary care. Fundamental and Clinical Pharmacology, 18, 201-206. Go to original source... Go to PubMed...
    8. Merlani G., Fox M., Oehen H.P., Cathomas G., Renner E.L., Fattinger K., Schneemann M., Kullak-Ublick G.A. (2001): Fatal hepatotoxicity secondary to nimesulide. European Journal of Clinical Pharmacology, 57, 321-326. Go to original source... Go to PubMed...
    9. Pasquale G., Scaricabarozzi I., D'Agostino R. (1993): An assessment of the efficacy and tolerability of nimesulide vs. paracetamol in children after adenotonsillectomy. Drugs, 46, 234-237. Go to original source... Go to PubMed...
    10. Prevot A., Mosig D., Martini S., Guignard J.P. (2004): Nimesulide, a cyclooxygenase-2 preferential inhibitor, impairs renal function in the newborn rabbit. Pediatric Research, 55, 254-260. Go to original source... Go to PubMed...
    11. Rabinovitz M., Von Thiel D.H. (1992): Hepatotoxicity of nonsteroidal anti-inflammatory drugs. The American Journal Gastroenterology, 87, 1696-1704.
    12. Ramesh N., Jayakuma K., Narayana K., Vijayasarathi S. K. (2001): Nimesulide toxicity in dogs. Indian Journal of Pharmacology, 33, 217-218.
    13. Robin M.A., Le Roy M., Descatoire V., Pessayre D. (1997): Plasma membrane cytochromes P450 as neoantigens and autoimmune targets in drug-induced hepatitis. Journal of Hepatology, 26, 23-30. Go to original source... Go to PubMed...
    14. Sbeit W., Krivoy N., Shiller M., Farah R., Cohen H.I., Struminger L., Reshef R. (2001): Nimesulide-induced acute hepatitis. The Annals of Pharmacotherapy, 35, 1049-1052. Go to original source... Go to PubMed...
    15. Schattner A., Sokolovskaya N., Cohen J. (2000): Fatal hepatitis and renal failure during treatment with nimesulide. Journal of Internal Medicine, 247, 153-155. Go to original source... Go to PubMed...
    16. Thawani V., Sontakke S., Gharpure K., Pimpalkhute S. (2003): Nimesulide: The Current Controversy. Indian Journal of Pharmacology, 35, 121-122.
    17. Van Steenbergen W., Peeters P., De Bondt Staessen D., Buscher H., Laporta T., Roskams T., Desmet V. (1998): Nimesulide-induced acute hepatitis: evidence from six cases. Journal of Hepatology, 29, 135-141. Go to original source... Go to PubMed...
    18. Vollmar A.M. (1993): Clinico-toxicologic aspects of nonsteroidal anti-inflammatory agents in the dog and cat. Tierarztliche Praxis, 21, 149-152.
    19. Weiss P., Mouallem M., Bruck R., Hassin D., Tanay A., Brickman C.M., Farfel Z., Bar-Meir S. (1999): Nimesulide-induced hepatitis and acute liver failure. Israel Medical Association Journal, 1, 89-91.
    20. Xavier F.G., Kogika M.M. (2002): Common causes of poisoning in dogs and cats in a Brazilian veterinary teaching hospital from 1998 to 2000. Veterinary and Human Toxicology, 44, 115-116.

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