Veterinární medicína, 2023 (vol. 68), issue 4
Citalopram in vitro metabolism in a beagle dog: A role for CYP2D15 in the production of toxic didesmethylcitalopram?Original Paper
B Rochat, E Paus, C Maitre, P Baumann
Vet Med - Czech, 2023, 68(4):135-144 | DOI: 10.17221/65/2022-VETMED
After administration of the serotonergic antidepressant citalopram (CIT) to beagle dogs, they may experience severe convulsive attacks in relation with considerably higher plasma concentrations of the metabolite didesmethyl-CIT (DDCIT), when compared to those in humans medicated with CIT. This pilot study aimed at determining the role of cytochrome P-450 (CYP450) isozymes in the in vitro metabolism of CIT to desmethyl-CIT (DCIT), and of DCIT to DDCIT in the liver microsomes of a single beagle dog. The incubations with racemic CIT or DCIT reveal a high affinity enzyme with Km between 0.3 µM and 1.4 µM for S- and R-DCIT and S- and R-DDCIT...
Efficacy of the intranasal application of azaperone for sedation in weaned pigletsOriginal Paper
M Svoboda, J Blahova, J Jarkovsky, A Zacharda, S Hajkova, J Vanhara, J Vasek
Vet Med - Czech, 2023, 68(4):145-151 | DOI: 10.17221/21/2023-VETMED
The aim of the study was to compare the efficacy of the intranasal and parenteral administration of azaperone in order to achieve pig sedation. A total of 32 weaned piglets divided into 4 groups (8 piglets in each group) were used. Group A was injected intramuscularly (i.m.) with azaperone (Stresnil®, 40 mg/ml inj.; Elanco Animal Health) at a dose of 2 mg/kg of body weight (b.w.). Group B received a dose of 2 mg/kg b.w. of azaperone intranasally. Group C was given azaperone intranasally at a dose of 4 mg/kg b.w. Group D was given 1 ml of saline intranasally and served...
The effect of cold atmospheric plasma (NO) alone and in combination with NPH insulin on the full-thickness excisional wound healing in a diabetic rat modelOriginal Paper
A Curukoglu, GCA Gungor, G Akan, A Kukner, G Ogutcu, M Kalaycı, M Temizel, FE Ozgencil
Vet Med - Czech, 2023, 68(4):152-163 | DOI: 10.17221/109/2022-VETMED
This study was planned to investigate an alternative treatment modality in diabetic wound healing. In this experimental study, the efficacy of both cold atmospheric plasma/nitric oxide (NO) and NPH insulin ointment, recently known to have beneficial effects on wound healing, was investigated in diabetic wound healing. Twenty-four (24) diabetic rats were divided into four groups DC, DI, DNO and DINO (diabetic control, diabetic insulin, diabetic nitric oxide, diabetic insulin + nitric oxide groups). No treatment was applied to the DC group, NPH insulin was applied to the DI group, CAP/NO was applied to the DNO group, and CAP/NO + NPH insulin was applied...
Mercury distribution in the great cormorant (Phalacrocorax carbo) from the Krogulna ponds and Nysa Kłodzka River (Poland)Original Paper
K Novotna Kruzikova, Z Siroka, T Kral, P Hliwa, P Gomulka, A Spodniewska, Z Svobodova
Vet Med - Czech, 2023, 68(4):164-174 | DOI: 10.17221/16/2023-VETMED
Mercury belongs among the highly hazardous substances present in the environment and represents a great health risk for many animals including predatory and piscivorous birds. The aim of this study was to assess the total mercury content in the main detoxifying organs (liver and kidney) and in the muscles of adult great cormorants (Phalacrocorax carbo) caught at two localities (the Krogulna ponds and the Nysa Kłodzka River) in southern Poland. The aim was to compare the locality with the iron ore mining history (the Krogulna ponds) with a site without such load (the Nysa Kłodzka River). The total mercury content in the great cormorants...
Histopathology and indicators of borderline ovarian tumours with microinvasion in bitchesCase Report
P Makovicky, P Bolgac, M Makovicka, K Kajo, Z Krchnikova, J Pokoradi, P Makovicky, Z Stanova, K Vaskova, K Rimarova
Vet Med - Czech, 2023, 68(4):175-183 | DOI: 10.17221/103/2022-VETMED
The authors present two cases of borderline ovarian tumours with microinvasion in bitches with variable clinical significance. The first case documents a four-year-old female Weimaraner diagnosed with a tumour on the right ovary during a veterinary check-up, using USG examination, which was then surgically removed. Histological examination revealed a clear cell borderline tumour of the ovary with microinvasion. The second case is represented by a necropsy sample from a 52-month-old female German shepherd which died a day before the planned hysterectomy due to undertreated pyometra. During necropsy, a developed form of bilateral ovarian tumour was found....