Vet Med - Czech, 2011, 56(9):423-429 | DOI: 10.17221/3205-VETMED
The role of beta-endorphin in horses: a review
- 1 Faculty of Veterinary Medicine, University of Life Sciences, Lublin, Poland
- 2 National Veterinary Research Institute, Pulawy, Poland
Opium alkaloids counterparts are secreted by human and animal organisms but the role of endogenous opioid peptides in horses has not yet been fully elucidated. Endogenous opioids are involved in regulating food intake, sexual and social activity, pain relief and pain threshold regulation in horses as well as in regulating the functions of the immune system. The aim of this review is to describe the endogenous opioid system in the horse and its function during stress, illness, reproduction, and its influence on immunity and on the formation of reactive oxygen species (ROS) in horses. What is currently known concerning beta-endorphin suggests that they can be a promising diagnostic or prognostic indicator of many pathologic states in horses.
Keywords: horse; endorphin; opioids
Published: September 30, 2011 Show citation
References
- Aurich JE, Dobrinski I, Parvizi N (1993): β-Endorphin in sows during late pregnancy: effects of cloprostenol and oxytocin on plasma concentrations of β-endorphin in the jugular and uterine veins. Journal of Endocrinology 136, 199-206.
Go to original source...
Go to PubMed...
- Bartosz G (2004): Second face of oxygen (in Polish). Wolne rodniki w przyrodzie. Wydawnictwo Naukowe PWN, Warszawa.
- Behrens C, Aurich JE, Klug E, Naumann H, Hoppen HO (1993): Inhibition of gonadotrophin release in mares during the luteal phase of the oestrous cycle by endogenous opioids. Journal of Reproduction and Fertility 98, 509-514.
Go to original source...
Go to PubMed...
- Billert H, Fiszer D, Drobnik L, Kurpisz M (1998): Influence of beta-endorphin on the production of reactive oxygen and nitrogen intermediates by rabbit alveolar macrophages. General Pharmacology 31, 393-397.
Go to original source...
Go to PubMed...
- Breen AP, Murphy JA (1995): Reactions of oxyl radicals with DNA. Free Radical Biology and Medicine 18, 1033-1077.
Go to original source...
Go to PubMed...
- Chadzinska M, Starowicz K, Scislowska-Czarnecka A, Bilecki W, Pierzchala-Koziec K, Przewlocki R, Przewlocka B, Plytycz B (2005): Morphine-induced changes in the activity of proopiomelanocortin and prodynorphin systems in zymosan-induced peritonitis in mice. Immunology Letters 101, 185-192.
Go to original source...
Go to PubMed...
- Dahlgren C, Karlsson A (1999): Respiratory burst in human neutrophils. Journal of Immunological Methods 232, 3-14.
Go to original source...
Go to PubMed...
- Davies KJA (1993): Protein modification by oxidants and the role of proteolytic enzymes. Biochemical Society Transactions 21, 346-353.
Go to original source...
Go to PubMed...
- Dinis TCP, Almeida LH, Madeira VMC (1993): Lipid peroxidation in sarcoplasmatic reticulum membrane and biophysical properties. Archives of Biochemistry and Biophysics 301, 256-264.
Go to original source...
Go to PubMed...
- Droge W (2002): Free radicals in the physiological control of cell function. Physiological Reviews 82, 47-95.
Go to original source...
Go to PubMed...
- Faletti AG, Mohn C, Farina M, Lomniczi A, Rettori V (2003): Interaction among beta-endorphin, nitric oxide and prostaglandins during ovulation in rats. Reproduction 125, 469-477.
Go to original source...
Go to PubMed...
- Fazio E, Medica P, Aronica V, Grasso L, Ferlazzo A (2008): Circulating β-endorphin, adrenocorticotrophic hormone and cortisol levels of stallions before and after short road transport: stress effect of different distances. Acta Veterinaria Scandinavica 50, 6.
Go to original source...
Go to PubMed...
- Fazio E, Medica P, Grasso L, Messineo C, Ferlazzo A (2009): Changes of circulating β-endorphin, adrenocorticotrophin and cortisol concentrations during growth and rearing in Thoroughbred foals. Livestock Science 125, 31-36.
Go to original source...
- Hamra JG, Kamerling SG, Wolfsheimer KJ, Bagwell CA (1993): Diurnal variation in plasma ir-beta-endorphin levels and experimental pain thresholds in the horse. Life Science 53, 121-129.
Go to original source...
Go to PubMed...
- Hunt JV, Dean RT, Wolff SP (1988): Hydroxyl radical production and autoxidative glycosylation. Glucose autoxidation as the cause of protein damage in the experimental glycation model of diabetes mellitius and ageing. Biochemical Journal 256, 205-212.
Go to original source...
Go to PubMed...
- Janson W, Stein C (2003): Peripheral opioid analgesia. Current Pharmaceutical Biotechnology 4, 270-274.
Go to original source...
Go to PubMed...
- Ji LL, Leeuwenburgh C, Leichtweis S, Gore M, Fiebig R, Hollander J, Bejma J (1998): Oxidative stress and aging: Role of exercise and its influences on antioxidant systems. Annals of the New York Academy of Sciences 854, 102-117.
Go to original source...
Go to PubMed...
- Kosterlitz HW, Hughes J (1975): Some thoughts on the significance of enkephalin, the endogenous ligand. Life Science 17, 91-96.
Go to original source...
Go to PubMed...
- Love S (1993): Equine Cushing's disease. British Veterinary Journal 149, 139-153.
Go to original source...
- Machelska H, Schopohl JK, Mousa SA, Labuz D, Schafer M, Stein C (2003): Different mechanisms of intrinsic pain inhibition in early and late inflammation. Journal of Neuroimmunology 141, 30-39.
Go to original source...
Go to PubMed...
- Marlin DJ, Fenn K, Smith N, Deaton CD, Roberts CA, Harris PA, Dunster C, Kelly FJ (2002): Changes in circulatory antioxidant status in horses during prolonged exercise. Journal of Nutrition 132, 1622-1627.
Go to original source...
Go to PubMed...
- Martyn P, Smith R, Owens PC, Lovelock M, Eng-Cheng Chan (1986): Immunoreactive β-endorphin and proγ-melanotropin in the peripheral circulation during the menstrual cycle. Asia-Oceania Journal of Obstetrics and Gynaecology 13, 3345-3350.
Go to original source...
- McCarthy RN, Jeffcott LB, Clarke IJ (1993): Preliminary studies on the use of plasma β-endorphin in horses as an indicator of stress and pain. Journal of Equine Veterinary Sciences 13, 216-219.
Go to original source...
- Mehl ML, Sarkar DK, Schott HC, Brown JA, Sampson SN, Bayly WM (1999): Equine plasma beta-endorphin concentrations are affected by exercise intensity and time of day. Equine Veterinary Journal 30 (Suppl.), 567-569.
Go to original source...
Go to PubMed...
- Millington WR, Dybdal NO, Dawson R Jr, Manzini C, Mueller GP (1988): Equine Cushing's disease: differential regulation of beta-endorphin processing in tumors of the intermediate pituitary. Endocrinology 123, 1598-1604.
Go to original source...
Go to PubMed...
- Mousa SA, Bopaiah CP, Stein C, Schafer M (2003): Involvement of corticotropin-releasing hormone receptor subtypes 1 and 2 in peripheral opioid-mediated inhibition of inflammatory pain. Pain 106, 297-307.
Go to original source...
Go to PubMed...
- Niinisto KE, Korolainen RV, Raekallio MR, Mykkanen AK, Koho NM, Ruohoniemi,MO, Leppaluoto J, Reeta Poso A (2010): Plasma levels of heat shock protein 72 (HSP72) and β-endorphin as indicators of stress, pain and prognosis in horses with colic. Veterinary Journal 184, 100-104.
Go to original source...
Go to PubMed...
- Pell SM, McGreevy PD (1999): A study of cortisol and beta-endorphin levels in stereotypic and normal Thoroughbreds. Applied Animal Behavior Science 64, 81-90.
Go to original source...
- Radunovic N, Lockwood CJ, Alvarez M, Nastic D, Berkowitz RL (1992): Beta-endorphin concentrations in fetal blood during the second half of pregnancy. American Journal of Obstetrics and Gynecology 167, 740-744.
Go to original source...
Go to PubMed...
- Raekallio M, Taylor PM, Bloomfield M (1997): A comparison of methods for evaluation of pain and distress after orthopaedic surgery in horses. Veterinary Anaesthesia and Analgesia 24, 17-20.
Go to original source...
- Refojo D, Kovalovsky D, Young JI, Rubinstein M, Holsboer F, Reul JM, Low MJ, Arzt E (2002): Increased splenocyte proliferative response and cytokine production in beta-endorphin-deficient mice. Journal of Neuroimmunology 131, 126-134.
Go to original source...
Go to PubMed...
- Roser JF (2008): Regulation of testicular function in the stallion: an intricate network of endocrine, paracrine and autocrine systems. Animal Reproduction Science 107, 179-196.
Go to original source...
Go to PubMed...
- Scott DW, Miller WH (2003): Equine Dermatology. Elsevier Science (USA).
Go to original source...
- Sharp BM, Keane WF, Suh HJ, Gekker G, Tsukayama D, Peterson PK (1985): Opioid peptides rapidly stimulate superoxide production by human polymorphonuclear leukocytes and macrophages. Endocrinology 117, 793-795.
Go to original source...
Go to PubMed...
- Soverchia L, Mosconi G, Ruggeri B, Ballarini P, Catone G, Degl'innocenti S, Nabissi M, Polzonetti-Magni AM (2006): Proopiomelanocortin gene expression and beta-endorphin localization in the pituitary, testis, and epididymis of stallion. Molecular Reproduction and Development 73, 1-8.
Go to original source...
Go to PubMed...
- Stefano GB, Salzet B, Fricchione GL (1998): Enkelytin and opioid peptide association in invertebrates and vertebrates: immune activation and pain. Immunology Today 19, 265-268.
Go to original source...
Go to PubMed...
- Sulowska Z, Majewska E, Krawczyk K, Klink M, Tchorzewski H (2002): Influence of opioid peptides on human neutrophil apoptosis and activation in vitro. Mediators of Inflammation 11, 245-250.
Go to original source...
Go to PubMed...
- Walport MJ, Duff GW (1998): Cells and mediators. In: Oxford Textbook of Rheumatology. Oxford University Press, Oxford. 503-524.
- Wardlaw SL, Frantz AG (1983): Brain β-endorphin during pregnancy, parturition, and the postpartum period. Endocrinology 113, 1664-1668.
Go to original source...
Go to PubMed...
This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International (CC BY NC 4.0), which permits non-comercial use, distribution, and reproduction in any medium, provided the original publication is properly cited. No use, distribution or reproduction is permitted which does not comply with these terms.