Vet Med - Czech, 2013, 58(5):271-276 | DOI: 10.17221/6809-VETMED

Comparative efficacy of various therapeutic protocols in the treatment of pyometra in bitchesOriginal Paper

B. Jena, K.S. Rao, K.C.S. Reddy, K.B.P. Raghavender
College of Veterinary Science, Sri Venkateswara Veterinary University, Rajendranagar, Hyderabad, Andhra Pradesh, India

This study was undertaken on canine pyometra and consisted of 28 bitches of different breeds with known breeding history and open type of pyometra. The diagnosis of pyometra was made by correlating the history and clinical signs with the findings of abdominal palpation, radiography and ultrasonography. The physiological, haematological and biochemical parameters were evaluated before and at the end of therapy. The clinical cases were divided randomly into four different groups with each group consisting of seven bitches. One untreated control group in which bitches were given only supportive therapies was included. The bitches in the other three groups were treated using natural PGF2α or synthetic PGF2α or a combination of a dopamine agonist prolactin-inhibiting drug, i.e., cabergoline and lower dose of synthetic PGF2α (Cloprostenol) along with supportive therapies. Treatment of canine pyometra by the use of different drugs was found to be successful. Though a lower dose of cloprostenol was effective in treating pyometra, it is not recommended due to high rates of recurrence and lower conception rates. Treatment of canine pyometra using a combination of a dopamine agonist prolactin-inhibiting drug (Cabergoline) and a lower dose of synthetic PGF2α (Cloprostenol) was found to be the most effective method among the three therapeutic protocols used in the present study.

Keywords: pyometra; treatment; natural prostaglandin; synthetic prostaglandin; cabergoline; side effects; recurrence rate; conception rate

Published: May 31, 2013  Show citation

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Jena B, Rao KS, Reddy KCS, Raghavender KBP. Comparative efficacy of various therapeutic protocols in the treatment of pyometra in bitches. Vet Med - Czech. 2013;58(5):271-276. doi: 10.17221/6809-VETMED.
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    References

    1. Coggan JA, Melville PA, Oliveira CM, Faustino M, Moreno AM, Benites NR (2008): Microbiological and histopathological aspects of canine pyometra. Brazilian Journal of Microbiology 39, 477-483. Go to original source...
    2. Corrada Y, Arias D, Rodriguez R, Tortora M, Gobello C (2006): Combination dopamine agonist and prostaglandin agonist treatment of cystic endometrial hyperplasia - pyometra complex in the bitch. Theriogenology 66, 1557-1559. Go to original source... Go to PubMed...
    3. England G, Yeager A, Concannon PW (2003): Ultrasound imaging of the reproductive tract of the bitch. In: Concannon PW, England G, Verstegen J, Linde-Forsberg C (eds.): Recent Advances in Small Animal Reproduction. International Veterinary Information Service, Ithaca, New York, USA.
    4. England GCW, Freeman SL, Russo M (2007): Treatment of spontaneous pyometra in 22 bitches with a combination of cabergoline and cloprostenol. Veterinary Record 160, 293-296. Go to original source... Go to PubMed...
    5. Fieni F (2006): Clinical evaluation of the use of aglepristone, with or without cloprostenol, to treat cystic endometrial hyperplasia-pyometra complex in bitches. Theriogenology 66, 1550-1556. Go to original source... Go to PubMed...
    6. Khan LA, Raghuwanshi DS, Vhora SC, Utage SG (2007): Efficacy of certain therapeutic regimens in canine pyometra. Indian Journal of Animal Reproduction 28, 49-52.
    7. Lein DH, Concannon PW, Hornbuckle WE, Gilbert RA, Glendening JR, Dunlap HL (1989): Termination of pregnancy in bitches by administration of prostaglandin F2α. Journal of Reproduction and Fertility Supplement 39, 231-240.
    8. Onclin K, Silva L D, Donnay I, Verstegen JP (1993): Luteotrophic action of prolactin in dogs and the effects of a dopamine agonist, cabergoline. Journal of Reproduction and Fertility Supplement 47, 403-409.
    9. Pande N, Prabhakar S, Gandotra VK, Nanda AS, Singla VK (2004): Comparative efficacy of parenteral and intravaginal administration of PGF2α for treatment of pyometra in bitches. Indian Journal of Animal Reproduction 25, 17-18.
    10. Pawde AM, Kumar H (1996): Medical management of canine pyometra complex. Indian Veterinary Journal 73, 197-198.
    11. Pelander L, Hagman R, Haggstrom J (2008): Concentrations of cardiac Troponin I before and after ovariohysterectomy in 46 female dogs with pyometra. Acta Veterinaria Scandinavica 50, 35. Go to original source... Go to PubMed...
    12. Reddy KRC, Rao KS, Raju KGS, Raghavender KBP, Reddy AG (2010): Therapeutic efficacy of Mifepristone, cabergoline and cloprostenol for termination of pregnanacy in bitches. Indian Journal of Animal Reproduction 31, 19-22.
    13. Schepper JD, Stock JVD, Capiau E (1987): The characteristic pattern of Aspartate Amino Transferase and Alanine Amino Transferase in the bitch with the cystic hyperplasia pyometra Complex: effect of medical or surgical treatment. Veterinary Research Communications 11, 65-75. Go to original source... Go to PubMed...
    14. Singh KP, Singh B, Singh JP, Singh S V, Singh P, Singh HN (2010): Diagnostic and therapeutic management of pyometra in bitches. Intas Polivet 11, 86-87. Go to original source...
    15. Smith FO (2006): Canine pyometra. Theriogenology 66, 610-612. Go to original source... Go to PubMed...
    16. Sridevi P, Balasubramanian S, Devanathan TG, Pattabiraman SR (2000): Low dose prostaglandin F2 alpha therapy in treatment of canine pyometra. Indian Veterinary Journal 77, 889-890.
    17. Tsumagari S, Ishinazaka T, Kamata H, Ohba S, Tanaka S, Ishii M, Memon MA (2005): Induction of canine pyometra by inoculation of Escherichia coli into the uterus and its relationship to reproductive features. Animal Reproduction Science 87, 301-308. Go to original source... Go to PubMed...
    18. Verstegen J, Dhaliwal G, Onclin KV (2008): Mucometra, cystic endometrial hyperplasia, and pyometra in the bitch: Advances in treatment and assessment of future reproductive success. Theriogenology 70, 364-374. Go to original source... Go to PubMed...

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