Vet Med - Czech, 2013, 58(5):277-283 | DOI: 10.17221/6810-VETMED

Determination of carcinoembryonic antigen and cancer antigen values with the radioimmunoassay method in healthy females dogsOriginal Paper

V. Ledecky1, A. Valencakova-Agyagosova1, J. Lepej2, Z. Frischova2, S. Hornak1, V. Nagy3
1 Small Animal Clinic, University of Veterinary Medicine and Pharmacy, Kosice, Slovak Republic
2 Institute of Nuclear and Molecular Medicine (INMM), Kosice, Slovak Republic
3 Medical Faculty and L. Pasteur University Hospital, Kosice, Slovak Republic

The aim of this study was to determine reference values of carcinoembryonic antigen and cancer antigen in 32 clinically healthy bitches. The average age of the bitches in each group was as follows: small breeds 3.50 ± 2.30, medium breeds 3.83 ± 3.21, large breeds 6.00 ± 3.22 and giant breeds 2.40 ± 2.43. The average weight in each group was as follows: 1st group 7.94 kg ± 1.84, 2nd group 22.38 kg ± 2.77, 3rd group 35.94 kg ± 7.16, and 4th group 52.75 kg ± 5.04. The cancer markers were determined using human kits. The mean values of the carcinoembryotic antigen markers ± SD were as follows: 1st group 0.18 ± 0.03, 2nd group 0.20 ± 0.03, 3rd group 0.22 ± 0.01, 4th group 0.18 ± 0.04. The statistical significance for the carcinoembryonic antigen markers was P = 0.0042**. The values of cancer antigen markers ± SD were: 4.90 ± 1.04, 4.80 ± 1.13, 5.90 ± 1.22, and 4.72 ± 0.97, respectively. The cancer antigen values were statistically insignificant (P = 0.1762). Based on obtained values of the mean 95%, we expect a standard for carcinoembryonic antigen of 0.00-0.23 ng/ml and for cancer antigen 0.0-7.00 IU/ml. The results of the present study show that it is possible to use human kits for the determination of carcinoembryonic antigen and cancer antigen in clinically healthy bitches using the radioimmunoassay method.

Keywords: canine; mammary gland; CEA; CA 15-3; tumor markers

Published: May 31, 2013  Show citation

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Ledecky V, Valencakova-Agyagosova A, Lepej J, Frischova Z, Hornak S, Nagy V. Determination of carcinoembryonic antigen and cancer antigen values with the radioimmunoassay method in healthy females dogs. Vet Med - Czech. 2013;58(5):277-283. doi: 10.17221/6810-VETMED.
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    References

    1. Akiyama F, Horii R (2009): Therapeutic strategies for breast cancer based on histological type. Breast Cancer 16, 168-172. Go to original source... Go to PubMed...
    2. Benjamin SA, Lee AC, Saunders WJ (1999): Classification and behavior of canine mammary epithelial neoplasm based on life-span observations in beagles. Veterinary Pathology 36, 423-436. Go to original source... Go to PubMed...
    3. Berruti A, Tampellini M, Torta M, Buniva T, Gorzegno G, Dogliotti L (1994): Prognostic value in predicting overall survival of two mucinous markers: CA 15-3 and CA 125 in breast cancer patients at first relapse of disease. European Journal of Cancer 30A, 2082- 2084. Go to original source... Go to PubMed...
    4. Bland KI, Beenken SW, Coopeland EM (2005): The Breast. In: Bruniardi FC, Anderson DK, Billjar TR, Dunn DL, Hunter JG, Pol-lock RE (eds.): Schwartz's Principles of Surgery. 8th McGraw-Hill Companies Inc., New York, NY. 453-496.
    5. Brodey RS, Goldschmidt MH, Roszel JR (1983): Canine mammary gland neoplasm. Journal of the American Animal Hospital Association 19, 61-90.
    6. Capik I, Sevcik A, Sevcikova Z (2008): Tumour diseases in dogs. Folia Veterinaria 52, 194-198.
    7. Ebeling FG, Stieber P, Untuch M, Nagel D, Konecny GE, Schmitt UM, Fateh-Moghadam A, Seidel D (2002): Serum CEA and CA 15-3 as prognostic factors in primary breast cancer. British Journal of Cancer 86, 1217-1222. Go to original source... Go to PubMed...
    8. Fiorella G, Patrizia F, Sandro C, Mariotti S, Spila A, Aloe S, D'Alessandro R, Carone MD, Cicchetti A, Ricciotti A, Venturo I, Perri P, Di Filippo F, Cognetti F, Botti C, Roselli M (2001): A re-evaluation of carcinoembryonic antigen (CEA) as a serum marker for breast cancer: a prospective longitudinal study. Clinical Cancer Research 7, 2357-2362.
    9. Hahn KA, Richardson RC, Knapp DW (1992): Canine malignant mammary neoplasia: Biological behaviour, diagnosis and treatment alternetives. Journal of American Animal Hospital Association 28, 251-256.
    10. Kausitz J, Altaner C et al. (eds.) (2003): Tumor Markers. In: Oncology (in Slovak). VEDA - Slovak Academy of Science Publishing, 1st ed. Bratislava. 119-124.
    11. Kitchel B, Loard A (1997): Diseases of mammary gland. In: Morgan RV (ed.): Handbook of Small Animal Practice. WB Saunders Company, Philadelphia. 615-625.
    12. Laessig D, Nagel D, Heinemann V, Untch M, Kahlert S, Baufrfeind I, Stieber P (2007): Importance of CEA and CA 15-3 during disease progression in metastatic breast cancer patients. Anticancer Research 27, 1963- 1968. Go to original source...
    13. Lamerz R, Stieber P, Fatel-Moghadam A (1993): Serum marker combinations in human breast cancer (review). In Vivo 7, 607-614. Go to PubMed...
    14. MacEwen EG (1990): Spontaneous tumors in dogs and cats: models for the study of cancer biology and treatment. Cancer Metastasis Review 9, 125-136. Go to original source... Go to PubMed...
    15. Misdorp W, Else RW, Hellman E, Lipscomb TP (1999): Histological classification of mammary tumors of the dog and cat. In: World Health Organization: International Histological Classification of Tumors of Domestic Animals. Vol. 7, ser. 2, no. 2, Armed Forces Institute of Pathology, Washington, DC.
    16. Molina R, Filella X, Alicarte J, Zanon G, Pahisa J, Munoz M, Farrus B, Ballesta AM (2003): Prospective evaluation of CEA and CA 15-3 in patients with locoregional breast cancer. Anticancer Research 23, 1035-1041.
    17. Molina R, Jo J, Fillela X, Gimenez N (1998): C-erbB-2 oncoprotein, CEA and CA 15-3 in patients with breast cancer: prognostic value. Breast Cancer Research and Treatment 51, 109-119. Go to original source... Go to PubMed...
    18. Muthuswamy S, Raste AS (2000): Clinical significance of the CA 15-3 in breast cancer. Indian Journal of Medical Science 54, 442-447.
    19. O'Hanlon DM, Kerin MJ, Kent PJ, Skehill R, Maher D, Grimes H, Given HF (1995): A prospective evaluation of CA 15-3 in Stage I carcinomas of the breast. Journal of the American College of Surgeon 180, 210-212.
    20. Owen LN (1980): Classification of Tumors in Domestic Animals. World Health Organization, Geneva.
    21. Park BW, Oh JW, Kim JH, Park SH, Kim KS, Kim JH, Lee KS (2008): Preoperative CA 15-3 and CEA serum levels as predictor for breast cancer outcomes. Annals of Oncology 19, 675-681. Go to original source... Go to PubMed...
    22. Safi F, Kohler I, Rottinger E, Beger HE (1991): The value of the tumor markers CA 15-3 in diagnosing and monitoring breast cancer. Cancer 68, 574-582. Go to original source...
    23. Sikorska H, Shuster J, Gold P (1988): Clinical applications of carcinoembryonic antigen. Cancer Detect Prevent Journal 12, 321-355.
    24. Winer EP, Morro WM, Kent OC, Harries JR (2001): Malignant tumors of the breast. In: Vincent T Devita Jr, Samuel Hellman, Steven A. Rosenberg: Cancer Principles and Practice of Oncology. 6th ed. Lippincott, Williams & Wilkins, 1698-1699.

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