Vet Med - Czech, 2014, 59(7):359-367 | DOI: 10.17221/7624-VETMED

Cholangiocarcinoma of intrahepatic bile ducts with disseminated metastases in a Siamese cat: a case reportCase Report

O. Aslan1, L. Cakir1, I.K. Bekdik1, Z. Dogan1, A.S. Tunc2
1 Faculty of Veterinary Medicine, Erciyes University, Kayseri,Turkey
2 Faculty of Veterinary Medicine, Ankara University, Ankara, Turkey

This case report concerns a four-year-old female Siamese cat which presented with inappetence, vomiting and weight loss. During routine clinical examinations of the patient, numerous neoplastic masses were detected in the liver, lungs and abdomen. Upon a request from the owner, the cat was euthanised. At necropsy, the primary tumour was detected in the liver. The tumour was greyish-white, firm, and multi-nodular. There were metastases in the portal lymph nodes, diaphragm, omentum, colon, caecum and lungs. Histologically, the tumour was characterised by a tubular pattern with periodic acid-Schiff- positive secretory material in glandular and canal structures. The neoplastic cells were positive to broad-spectrum cytokeratin. Histochemical and immunohistochemical stains were consistent with an intrahepatic bile duct carcinoma. This is the first case to report the metastasis of a cholangiocellular carcinoma to the colon in cats.

Keywords: cat; cholangiocellular carcinoma; colon; Siamese

Published: July 31, 2014  Show citation

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Aslan O, Cakir L, Bekdik IK, Dogan Z, Tunc AS. Cholangiocarcinoma of intrahepatic bile ducts with disseminated metastases in a Siamese cat: a case report. Vet Med - Czech. 2014;59(7):359-367. doi: 10.17221/7624-VETMED.
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    References

    1. Adler R, Wilson DW (1995): Biliary cystadenomas in cats. Veterinary Pathology 32, 415-418. Go to original source... Go to PubMed...
    2. Balaton AJ, Nehama-Sibony M, Gotheil C, Callard P, Baviera EE (1988): Distinction between hepatocellular carcinoma, cholangiocarcinoma, and metastatic carcinoma based on immunohistochemical staining for carcinoembryonic antigen and for cytokeratin 19 on paraffin sections. Journal of Pathology 156, 305-310. Go to original source... Go to PubMed...
    3. Catalano O, Nunziata A, Lobianco R, Sian A (2005): Real-time harmonic contrast material-specific us of focal liver lesions. Radiographics 25, 333-349. Go to original source... Go to PubMed...
    4. Choi BI, Han JK, Hong ST, Lee KH (2004): Clonorchiasis and cholangiocarcinoma: etiologic relationship and imaging diagnosis. Clinical Microbiology Reviews 17, 540-542. Go to original source... Go to PubMed...
    5. Ciftci MK, Ortatatli M, Avki S (1998): Cholangiocellular carcinoma in a cat (in Turkish). Veteriner Bilimleri Dergisi 14, 91-96.
    6. Cullen JM, Poop JA (2002): Tumours of the liver and gallbladder. In: Meuten DJ (ed.): Tumours in Domestic Animals. 4th ed. Iowa State Pres, Iowa, USA. 495-499.
    7. Fucich LF, Cheles MK, Thung SN, Gerber MA, Marrogi AJ (1994): Primary metastatic hepatic carcinoma. An immunohistochemical study of 34 cases. Archives of Pathology and Laboratory Medicine 118, 927-930.
    8. Hammer AS, Sikkema DA (1995): Hepatic neoplasia in the dog and cat. Veterinary Clinics of North America: Small Animal Practice 25, 419-435. Go to original source... Go to PubMed...
    9. Hou PC (1964): Primary carcinoma of the bile duct of the liver of the cat (Felis catus) infested with Chonorchis sinesis. Journal of Pathology and Bacteriology 87, 239-244. Go to original source... Go to PubMed...
    10. Ilhan F, Yener Z, Vural SA, Haligur M (2008): Mucinous cholangiocarcinoma with metastases in a Turkish Van cat - a case report. Bulletin of the Veterinary Institute in Pulawy 52, 131-134.
    11. Jacobs TM, Snyder PW (2007): Mucinous cholangiocarcinoma in a cat. Journal of the American Animal Hospital Association 43, 168-172. Go to original source... Go to PubMed...
    12. Joshita S, Ichijo T, Suzuki F, Yokoyama T, Sugiyama Y, Fukushima M, Kamijo A, Komatsu M, Umemura T, Yoshizawa K, Miyagawa S, Tanaka E (2009): A case of well differentiated cholangiolocellular carcinoma visualized with contrast-enhanced ultrasonography using Sonazoid. Hepatology Research 39, 207-212. Go to original source... Go to PubMed...
    13. Kakar S, Muir T, Murphy LM, Lloyd RV, Burgart LJ (2003): Immunoreactivity of Hep Par 1 in hepatic and extrahepatic tumors and its correlation with albumin in situ hybridization in hepatocellular carcinoma. American Journal of Clinical Pathology 119, 361-366. Go to original source... Go to PubMed...
    14. Kurashina M, Kozuka S, Nakasima N, Hirabayasi N, Ito M (1988): Relationship of intrahepatic bile duct hyperplasia to cholangiocellular carcinoma. Cancer 61, 2469-2474. Go to original source...
    15. Lawrence HJ, Erb HN, Harvey HJ (1994): Non-lymphomatous hepatobiliary masses in cats: 41 cases (1972- 1991). Veterinary Surgery 23, 365-368. Go to original source... Go to PubMed...
    16. Lepri E, Sforna M, Brachelente C, Vitellozzi G (2013): Cholangiocarcinoma of intrahepatic bile ducts with disseminated metastases in an African lion (Panthera leo). Journal of Zoo and Wildlife Medicine 44, 509-512. Go to original source... Go to PubMed...
    17. Liptak JM, Dernell WS, Withrow AS (2004): Liver tumors in cats and dogs. Compendium on Continuing Education for the Practising Veterinarian 26, 50-56.
    18. Martín De Las Mulas J, Gomez-Villamandos JC, Perez J, Mozos E, Estrada M, Mendez A (1995): Immunohistochemical evaluation of canine primary liver carcinomas: distribution of alpha-fetoprotein, carcinoembryonic antigen, keratins and vimentin. Research in Veterinary Science 59, 124-127. Go to original source... Go to PubMed...
    19. Miller RE, Boever WJ, Thomburg LP, Curtis Velasco M (1985): Hepatic neoplasia In two polar bears. Journal of the American Veterinary Medical Association 187, 1256-1258. Go to PubMed...
    20. Mischke R, Hoinghaus R, Lutkefels E, Buhl K, Gerhardt A, Hewicker-Trautwein M (2003): Immunocytological confirmation of bone marrow metastases in a dog with cholangiocarcinoma. Journal of Small Animal Practice 44, 411-414. Go to original source... Go to PubMed...
    21. Moore AS, Ogilvie GK (2001): Splenic, hepatic and pancreatic tumours. In: Moore AS, Ogilvie GK (eds): Feline Oncology. Trenton: Veterinary Learning Systems. WB Saunders, Philadelphia. 295-310.
    22. Munro R, Youngson RW (1996): Hepatocellular tumours in roe deer in Britain. Veterinary Record 138, 542-546. Go to original source... Go to PubMed...
    23. Okuda K, Nakanuma Y, Miyazaki M (2002): Cholangiocarcinoma: recent progress. Part 2: Molecular pathology and treatment. Journal of Gastroenterology and Hepatology 17, 1056-1063. Go to original source... Go to PubMed...
    24. Olnes MJ, Erlich R (2004): A review and update on cholangiocarcinoma. Oncology 66, 167-179. Go to original source... Go to PubMed...
    25. Patnaik AK, Hurvitz AI, Lieberman H (1980): Canine hepatic neoplasms: A clinicopathologic Study. Veterinary Pathology 17, 553-564. Go to original source... Go to PubMed...
    26. Post G, Patnaik AK (1992): Nonhaematopoietic hepatic neoplasm in cats: 21 cases (1983-1988). Journal of American Veterinary Medical Association 201, 1080-1082.
    27. Shiga A, Shirota K, Enomoto M (2001): Combined hepatocellular and cholangiocellular carcinoma in a dog. Journal of Veterinary Medical Science 63, 483-486. Go to original source... Go to PubMed...
    28. Sirica AE (2005): Cholangiocarcinoma: molecular targeting strategies for chemoprevention and therapy. Hepatology 41, 5-15. Go to original source... Go to PubMed...
    29. Thamm DH (2001): 4.21.F Hepatobiliary tumours. In: Withrow SJ, MacEwen EG (eds.): Small Animal Clinical Oncology. 3rd ed. WB Saunders, Philadelphia. 327-334.
    30. Theise ND, Saxena R, Portmann BC, Thung SN, Yee H, Chiriboga L, Kumar A, Crawford JM (1999): The canals of hering and hepatic stem cells in humans. Hepatology 30, 1425-1433. Go to original source... Go to PubMed...
    31. Uygun A, Polat Z (2009): Other than viral hepatitis, diseases causing increase in serum transaminase levels (in Turkish). Guncel Gastroenteroloji 13, 211-224.
    32. Wakahara T, Tsukamoto T, Kitamura S, Watanabe A, Tsujimura T, Nakamura Y, Toyokawa A, Onishi N, Hamabe Y, Mukai H, Teramura K (2005): Metastatic colon cancer from intrahepatic cholangiocarcinoma. Journal of Hepato-biliary-pancreatic Surgery 12, 415-418. Go to original source... Go to PubMed...

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