Vet Med - Czech, 2017, 62(1):48-51 | DOI: 10.17221/48/2016-VETMED

Cutaneous leishmaniosis in a dog vaccinated with LiESP/QA-21: effective or defective vaccine-related immune surveillance? A case reportCase Report

A. de Cosmo1, D. Mazzoni2, A. Campanati3, G.E. Magi1, D. Beghelli*,1
1 School of Biosciences and Veterinary Medicine, University of Camerino, Camerino, Italy
2 Dorica Veterinary Clinic, Ancona, Italy
3 Dermatological Clinic, Polytechnic Marche University, Ancona, Italy

Leishmania, an intracellular protozoan parasite, is endemic, widespread and represents a public health problem in most countries of the Mediterranean basin as it is implicated in a wide spectrum of diseases both in humans and animals. Vaccination of canines remains the best control strategy to counteract the progression of active infection for canine disease in areas of the world where transmission to humans is primarily zoonotic. This case report describes the history of a four-year-old dog vaccinated against canine leishmaniosis that was presented to a private clinic for the onset of a nodular skin lesion. Besides normal haematological and biochemical analyses, the histopathological examination of the removed skin lesion revealed the presence of Leishmania amastigotes. The presence of the protozoa in the skin lesion of a vaccinated dog is discussed.

Keywords: Leishmania infantum; skin nodule; vaccine; amastigote

Published: January 31, 2017  Show citation

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de Cosmo A, Mazzoni D, Campanati A, Magi GE, Beghelli D. Cutaneous leishmaniosis in a dog vaccinated with LiESP/QA-21: effective or defective vaccine-related immune surveillance? A case report. Vet Med - Czech. 2017;62(1):48-51. doi: 10.17221/48/2016-VETMED.
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    References

    1. Alexandre-Pires G, Villa de Brito MT, Alguero C, Martins C, Roos Rodrigues O, Pereira da Fonseca I, Santos-Gomes G (2010): Canine leishmaniosis. Immunophenotypic profile of leukocytes in different compartments of symptomatic, asymptomatic and treated dogs. Veterinary Immunology and Immunopathology 137, 275-283. Go to original source... Go to PubMed...
    2. Alvar J, Canavate C, Molina R, Moreno R, Nieto J (2004): Canine leishmaniosis. Advances in Parasitology 57, 1-88. Go to original source... Go to PubMed...
    3. Amara A, Jemli MH, Kilani M, Ghorbel A, Aouina M (2000): A case of Leishmania nodular dermatitis in a dog (in French). Le Point Veterinaire 31, 514-516.
    4. Blavier A, Keroack S, Denerolle P, Goy-Thollot I, Chabanne L, Cadore JL, Bourdoiseau G (2001): Atypical forms of canine leishmaniosis. The Veterinary Journal 162, 108-120. Go to original source... Go to PubMed...
    5. Bongiorno G, Paparcone R, Foglia Manzillo V, Oliva G, Cuisinier AM, Gradoni L (2013): Vaccination with LiESP/ QA-21 (CaniLeish®) reduces the intensity of infection in Phlebotomus perniciosus fed on Leishmania infantum infected dogs - A preliminary xenodiagnosis study. Veterinary Parasitology 197, 691-695. Go to original source... Go to PubMed...
    6. Dye C (1996): The logic of visceral leishmaniasis control. American Journal of Tropical Medicine and Hygiene 55, 125-130. Go to original source... Go to PubMed...
    7. Ferrer L, Rabanal R, Fondevila D, Ramos JA, Domingo M (1988): Skin lesions in canine leishmaniosis. Journal of Small Animal Practice 29, 381-388. Go to original source...
    8. Ferrer L, Fondevila D, Marco A, Pumarola M (1990): Atypical nodular leishmaniosis in two dogs. Veterinary Record 126, 90.
    9. Handler MZ, Patel PA, Kapila R, Al-Qubati Y, Schwartz RA (2015): Cutaneous and mucocutaneous leishmaniasis. Clinical perspectives. Journal of the American Academy Dermatology 73, 897-908. Go to original source... Go to PubMed...
    10. Kahime K, Boussaa S, Laamrani-El Idrissi A, Nhammi H, Boumezzough A (2015): Epidemiological study on acute cutaneous leishmaniasis in Morocco. Journal of Acute Disease 5, 41-45. Go to original source...
    11. Koutinas AF, Scott DW, Kantos V, Lekkas L (1992): Skin lesions in canine leishmaniosis (Kala-Azar): a clinical and histopathological study on 22 spontaneous cases in Greece. Veterinary Dermatology 3, 121-130. Go to original source...
    12. Moreno J, Vouldoukis I, Schreiber P, Martin V, McGahie D, Gueguen S, Cuisinier AM (2014): Primary vaccination with the LiESP/QA-21 vaccine (CaniLeish®) produces a cellmediated immune response which is still present 1 year later. Veterinary Immunology and Immunopathology 158, 199-207. Go to original source... Go to PubMed...
    13. Oliva G, Nieto J, Manzillo VF, Cappiello S, Fiorentino E, Di Muccio T, Scalone A, Moreno J, Chicharro C, Carrillo E, Butaud T, Guegand L, Martin V, Cuisinier AM, McGahie D, Gueguen S, Canavate C, Gradoni L (2014): A randomised, double-blind, controlled efficacy trial of the LiESP/QA-21 vaccine in naive dogs exposed to two Leishmania infantum transmission seasons. PLOS Neglected Tropical Diseases 8. Available: http://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0003213. Go to original source...
    14. Otranto D, Dantas-Torres F (2013): The prevention of canine leishmaniasis and its impact on public health. Trends in Parasitology 7, 339-345. Go to original source... Go to PubMed...
    15. Paltrinieri S, Solano-Gallego L, Fondati A, Lubas G, Gradoni L, Castagnaro M, Crotti A, Maroli M, Oliva G, Roura X, Zatelli A, Zini E (2010): Guidelines for diagnosis and clinical classification of leishmaniasis in dogs. JAVMAJournal of the American Veterinary Medical Association 236, 1184-1191. Go to original source... Go to PubMed...
    16. Viegas C, Requicha J, Albuquerque C, Sargo T, Machado J, Dias I, Pires MA, Campino L, Cardoso L (2012): Tongue nodules in canine leishmaniosis - a case report. Parasites and Vectors 5, 120. Go to original source... Go to PubMed...
    17. Vidor E, Dereure J, Pratlong F, Dubreuil N, Bissuel G, Moreau Y, Rioux JA (1991): The site of inoculation of Leishmania infantum in the canine leishmaniosis. Study of a cohort in traditional Cevennes Region (in French). Pratique Medicale et Chirurgicale de l'Animale de Compagnie 26, 133-137.

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