Vet Med - Czech, 2019, 64(8):373-378 | DOI: 10.17221/116/2018-VETMED

Mycophenolate mofetil plus prednisolone combination therapy for necrotising leukoencephalitis in a dog: long-term clinical observation, serial imaging analysis and histopathological findingsCase Report

Su Jin An1, Joon Hyeok Jeon1, Do Hyeon Yu1, Joong Hyun Song1, Hee Chun Lee1, Ki Chang Lee2, Jung Hyang Sur3, Dong In Jung*,1
1 Institute of Animal Medicine, College of Veterinary Medicine, Gyeongsang National University, Jinju, Republic of Korea
2 College of Veterinary Medicine, Chonbuk National University, Jeonju, Republic of Korea
3 Department of Pathobiology, Small Animal Tumor Diagnostic Center, College of Veterinary Medicine, Konkuk University, Seoul, Republic of Korea

An 8-year-old intact male mixed-breed dog presented with tetraparesis, right side head tilt, and cluster seizure-like episodes. Based on the magnetic resonance imaging and cerebrospinal fluid analysis results, meningoencephalitis of an unknown aetiology was strongly suspected. The patient survived for 963 days under mycophenolate mofetil plus prednisolone therapy and was ultimately diagnosed with necrotising leukoencephalitis. This report describes the clinical findings, the serial magnetic resonance imaging characteristics, and the histopathologic features of a case of necrotising leukoencephalitis and the long-term survival after mycophenolate mofetil plus prednisolone therapy.

Keywords: autoimmune encephalitis; magnetic resonance imaging (MRI); meningoencephalitis of an unknown aetiology (MUE); necrotising meningoencephalitis (NME)

Published: August 31, 2019  Show citation

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An SJ, Jeon JH, Yu DH, Song JH, Lee HC, Lee KC, et al.. Mycophenolate mofetil plus prednisolone combination therapy for necrotising leukoencephalitis in a dog: long-term clinical observation, serial imaging analysis and histopathological findings. Vet Med - Czech. 2019;64(8):373-378. doi: 10.17221/116/2018-VETMED.
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