Vet Med - Czech, 2022, 67(1):51-58 | DOI: 10.17221/8/2021-VETMED

Congenital hydrocephalus in three sheep: Clinical, electroencephalographic and pathological featuresCase Report

M Masucci ORCID...1, MT Capucchio2, R Buttitta3, E Colombino2, SA Mignacca4
1 Department of Veterinary Sciences, University of Messina, Messina, Italy
2 Department of Veterinary Sciences, University of Turin, Turin, Italy
3 Veterinary Practitioner, Ambulatorio Veterinario Gagliardo, Bagheria (Palermo), Italy
4 Veterinary Practitioner, Enna, Italy

The clinical, electroencephalographic and neuro-pathological features of three cases (cases 1, 2 and 3) of congenital hydrocephalus in sheep were described. The observed neurological signs reflected damage in the telencephalon and brain stem. The electroencephalogram performed in case 1 and case 2 showed different patterns: symmetric and synchronous high-voltage slow-activity in case 1, and low-voltage slow-activity in case 2. By the post-mortem examination, in all the animals, dilatation of the ventricular system, especially of the lateral ventricles, associated with a glial reaction surrounding the dilated ventricles was observed. Only in case 3, a monolateral meningeal thickening at the left cerebellopontine angle seemed to be responsible for the obstructive hydrocephalus. In the other two brains (case 1 and 2), no potential anatomical cause for the hydrocephalus were detected, even if, in case 2, a compensatory form was not excluded due to the moderate hypoplasia of the cerebrum and the presence of the non-suppurative inflammation. The results of this work provide a contribution to the EEG characterisation in ovine hydrocephalus cases; nevertheless further multidisciplinary studies of a larger number of sheep could permit to better characterise the EEG pattern in ovine hydrocephalus cases.

Keywords: brain; electroencephalogram; malformation; neuropathology; sheep

Received: January 19, 2021; Accepted: August 24, 2021; Published: January 15, 2022  Show citation

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Masucci M, Capucchio M, Buttitta R, Colombino E, Mignacca S. Congenital hydrocephalus in three sheep: Clinical, electroencephalographic and pathological features. Vet Med - Czech. 2022;67(1):51-58. doi: 10.17221/8/2021-VETMED.
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    References

    1. Adjou K, Miche N, Brugere-Picoux J. Principali patologie del sistema nervoso degli ovini [Main pathologies of the nervous system of sheep]. Summa Anim Reddito. 2007 Apr;2(3):11-9. Italian.
    2. Armasu M, Stanciu GD, Musteata M, Mocanu D, Solcan G. Electroencephalographic aspects in dogs with congenital hydrocephalus. Bull UASVM Vet Med. 2014 Jul;71(2): 305-12. Go to original source...
    3. Binns W, Shupe JL, Keeler RF, James LF. Chronologic evaluation of teratogenicity in sheep fed Veratrum californicum. J Am Vet Med Assoc. 1965 Oct 15;147(8):839-42.
    4. Cwynar P, Kolacz R, Walerjan P. Electroencephalographic recordings of physiological activity of the sheep cerebral cortex. Pol J Vet Sci. 2014 Oct;17(4):613-23. Go to original source... Go to PubMed...
    5. Cwynar P, Zawadzki W. Recording of bioelectrical activity changes in sheep cerebral cortex. Arch Med Vet. 2010 Jan;42(2):51-62. Go to original source...
    6. de Lahunta A, Glass E. Cerebrospinal fluid and hydrocephalus. In: de Lahunta A, Glass E, editors. Veterinary neuroanatomy and clinical neurology. St Louis (MO): Saunders Elsevier; 2009. p. 54-76. Go to original source...
    7. Dennis SM. Congenital defects of the nervous system of lambs. Aust Vet J. 1975 Aug;51(8):385-8. Go to original source... Go to PubMed...
    8. Edwards JF, Livingston CW, Chung SI, Collisson EC. Ovine arthrogryposis and central nervous system malformations associated with in utero Cache Valley virus infection: Spontaneous disease. Vet Pathol. 1989 Jan;26(1):33-9. Go to original source... Go to PubMed...
    9. Haughey KG, Hartley WJ, Della-Porta AJ, Murray MD. Akabane disease in sheep. Aust Vet J. 1988 May;65(5):136-40. Go to original source... Go to PubMed...
    10. Klemm WR, Hall CL. Electroencephalograms of anesthetized dogs with hydrocephalus. Am J Vet Res. 1971 Nov; 32(11):1859-64. Go to original source...
    11. Klemm WR, Hall CL. Electroencephalographic pattern abnormalities in dogs with neurologic disorders. Am J Vet Res. 1972 Oct;33(10):2011-25.
    12. Lavigne GJ, Kato T, Kolta A, Sessle BJ. Neurobiological mechanisms involved in sleep bruxism. Crit Rev Oral Biol Med. 2003;14(1):30-46. Go to original source... Go to PubMed...
    13. Masucci M, Mignacca SA, Capucchio MT, Biasibetti E. Un caso di idrocefalo congenito nella pecora [A case of congenital hydrocephalus in sheep]. Large Anim Rev. 2012 Aug;18(4):193-6. Italian.
    14. Miller AW. Hydrocephalus in a flock of Suffolk sheep. Vet Rec. 1993 Feb 27;132(9):228. Go to original source... Go to PubMed...
    15. Okurowska-Zawada B, Sobaniec W, Kulak W, SmigielskaKuzia J, Paszko-Patej G, Sienkiewicz D, Sendrowski K. Clinical-electroencephalographic analysis of brain bioelectrical activity in children with myelomeningocele and internal hydrocephalus. Adv Med Sci. 2007 Feb;52(Suppl_1): 200-3.
    16. Pampiglione G. Development of some rhythmic activity in the EEG of young pigs, lambs and puppies. Rev Electroencephalogr Neurophysiol Clin. 1977 Jul-Sep;7(3): 255-62. Go to original source... Go to PubMed...
    17. Potter KA, Weston JF, Munday JS, Johnstone AC. Spina bifida with associated malformations of the central nervous system in Dorper-cross sheep. N Z Vet J. 2010 Dec; 58(6):315-8. Go to original source... Go to PubMed...
    18. Pritchard GC, Jeffrey M, Welchman DB, Windsor RS, Morgan G. Multiple cases of Dandy-Walker malformation in three sheep flocks. Vet Rec. 1994 Aug 13;135(7):163-4. Go to original source... Go to PubMed...
    19. Prynn RB, Redding RW. Electroencephalogram in occult canine hydrocephalus. J Am Vet Med Assoc. 1968 Jun 1; 152(11):1651-7.
    20. Redding RW, Knecht CE. The electroencephalogram in organic disease of the SNC. In: Redding RW, Knecht CE, editors. Atlas of electroencephalography in the dog and cat. New York (NY): Pragaer; 1984. p. 270-331.
    21. Redding RW. Electrophysiologic diagnosis. Section 1 - Electroencephalography. In: Oliver JE, Hoerlein BF, Mayhew IG, editors. Veterinary neurology. Philadelphia (PA): WB Saunders Company; 1987. p. 111-45.
    22. Saito T, Watanabe Y, Nemoto T, Kasuya E, Sakumoto R. Radiotelemetry recording of electroencephalogram in piglets during rest. Physiol Behav. 2005 Apr 13;84(5):725-31. Go to original source... Go to PubMed...
    23. Sarnat HB. Ependymal reactions to injury. A review. J Neuropathol Exp Neurol. 1995 Jan;54(1):1-15. Go to original source... Go to PubMed...
    24. Smith MO, George LW. Diseases of the nervous system. In: Smith BP, editor. Large animal internal medicine. St Louis (MO): Mosby Elsevier; 2009. p. 972-1143.
    25. VanderKop M. Alberta. Border disease in a flock of commercial sheep. Can Vet J. 1991 Dec;32(12):750-1.
    26. Woods LW, Anderson ML. Scoliosis and hydrocephalus in an ovine fetus infected with Toxoplasma gondii. J Vet Diagn Invest. 1992 Apr;4(2):220-2. Go to original source... Go to PubMed...

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