Vet Med - Czech, 2022, 67(10):544-551 | DOI: 10.17221/70/2021-VETMED

Successful management of feline CD4+ CD8+ T-cell mediastinal lymphoma with pericardial effusionCase Report

SJ Yu1, HE Kim2, HJ Han3, JH Kim1
1 Department of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University, Gwangjin-gu, Seoul, Republic of Korea
2 Department of Veterinary Internal Medicine, Konkuk University Veterinary Medical Teaching Hospital, Gwangjin-gu, Seoul, Republic of Korea
3 Veterinary Emergency Medicine and Critical Care, Konkuk University Veterinary Medical Teaching Hospital, Gwangjin-gu, Seoul, Republic of Korea

A 2-year-old, castrated, male Russian blue cat presented with acute dyspnoea, cyanosis, and lethargy. A thoracic radiography revealed a large cranial mediastinal mass; the computed tomography revealed caudal lobe atelectasis of the right lung with pericardial and pleural effusions. The cytodiagnostic tests revealed high-grade CD4+ CD8+ T-cell mediastinal lymphoma as clinical stage Vb; l-asparaginase-cyclophosphamide-doxorubicin-vincristine-prednisolone (l-CHOP)-based chemotherapy was initiated, following which the mass shrunk rapidly; 1 week after the initiation of chemotherapy, the appetite-related and respiratory symptoms improved dramatically, and the pleural and pericardial effusion resolved. The patient remains in complete remission three years after the initiation of the l-CHOP chemotherapy. Therefore, the accurate diagnosis and instantaneous initiation of chemotherapy may resolve life-threatening pleural and pericardial effusions in cats with high-grade aberrant T-cell mediastinal lymphoma.

Keywords: cat; flow cytometry; l-CHOP; multi-agent chemotherapy; pleural effusion

Received: May 7, 2021; Accepted: April 28, 2022; Prepublished online: July 25, 2022; Published: October 15, 2022  Show citation

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Yu S, Kim H, Han H, Kim J. Successful management of feline CD4+ CD8+ T-cell mediastinal lymphoma with pericardial effusion. Vet Med - Czech. 2022;67(10):544-551. doi: 10.17221/70/2021-VETMED.
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