Vet Med - Czech, 2023, 68(4):175-183 | DOI: 10.17221/103/2022-VETMED

Histopathology and indicators of borderline ovarian tumours with microinvasion in bitchesCase Report

P Makovicky1, P Bolgac2, M Makovicka3, K Kajo4, Z Krchnikova5, J Pokoradi5, P Makovicky6, Z Stanova7, K Vaskova7, K Rimarova8
1 Infectious Diseases and Preventive Medicine, Veterinary Research Institute, v. v. i., Brno, Czech Republic
2 Department of Pathology, Veterinary and Food Institute, Bratislava, Slovak Republic
3 Department of Histology and Embryology, Faculty of Medicine, University of Ostrava, Czech Republic
4 Department of Pathology, St. Elisabeth Cancer Institute, Bratislava, Slovak Republic
5 Veterinary clinic – Animal Reproduction Centre, s.r.o., Budmerice, Slovak Republic
6 Department of Biology, Faculty of Education, J. Selye University, Komarno, Slovak Republic
7 Department of Zoology, Faculty of Natural Sciences, Comenius University, Bratislava, Slovak Republic
8 Department of Public Health and Hygiene, Faculty of Medicine, Pavol Jozef Safarik University in Kosice, Slovak Republic

The authors present two cases of borderline ovarian tumours with microinvasion in bitches with variable clinical significance. The first case documents a four-year-old female Weimaraner diagnosed with a tumour on the right ovary during a veterinary check-up, using USG examination, which was then surgically removed. Histological examination revealed a clear cell borderline tumour of the ovary with microinvasion. The second case is represented by a necropsy sample from a 52-month-old female German shepherd which died a day before the planned hysterectomy due to undertreated pyometra. During necropsy, a developed form of bilateral ovarian tumour was found. An additional histological examination diagnosed a serous borderline tumour with microinvasion of both ovaries. This paper discusses the histopathological and clinical aspects involved in the prognosis of borderline ovarian tumours in bitches, This concerns the possibility of a change for a more aggressive form of the behaviour of these tumours and their immunohistochemical profile, then the risk of implant metastases and, finally, the time point of diagnosis, intervention and therapy. Even histologically verified well-differentiated forms of borderline ovarian tumours with microinvasion in bitches can show variable clinical significance and, therefore, in similar cases, only a good or only a bad prognosis of the disease should not be expected.

Keywords: gynaecological diseases; implantation metastases; prognostic significance; veterinary pathology

Received: November 17, 2022; Revised: February 27, 2023; Accepted: March 8, 2023; Prepublished online: March 28, 2023; Published: April 28, 2023  Show citation

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Makovicky P, Bolgac P, Makovicka M, Kajo K, Krchnikova Z, Pokoradi J, et al.. Histopathology and indicators of borderline ovarian tumours with microinvasion in bitches. Vet Med - Czech. 2023;68(4):175-183. doi: 10.17221/103/2022-VETMED.
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