Vet Med - Czech, 2024, 69(2):61-66 | DOI: 10.17221/99/2023-VETMED

Concurrent primary splenic lymphoma and mammary gland tumour with polycystic ovaries in a dogCase Report

SH Kim ORCID...1, YB Baek ORCID...2, SI Park ORCID...3
1 Laboratory of Veterinary Surgery, College of Veterinary Medicine, Chonnam National University, Gwangju, Republic of Korea
2 Laboratory of Veterinary Pathology, College of Veterinary Medicine, Chonnam National University, Gwangju, Republic of Korea
3 Laboratory of Veterinary Pathology, College of Veterinary Medicine, Chonnam National University, Gwangju, Republic of Korea; College of Veterinary Medicine and BK21 FOUR Program, Chonnam National University, Gwangju, Republic of Korea

Here, we report a rare case of concurrent primary splenic lymphoma and mammary gland tumour (MGT) with polycystic ovaries in a 10-year-old, intact female Jindo dog. The dog was presented with multiple masses in the fourth left mammary gland, the largest of which measured 6 cm in diameter, along with enlargement of the left inguinal lymph node on physical examination. Ultrasonography, radiography, and computed tomography scans revealed polycystic ovaries and a mass in the tail of the spleen, after total splenectomy and mastectomy with ovariohysterectomy, histopathological examination identified splenic diffuse large B cell lymphoma and malignant myoepithelioma of the mammary gland was found. To our knowledge, this is the first report of the concurrent occurrence of splenic lymphoma, MGT, and polycystic ovaries in a dog.

Keywords: lymphoma; mammary gland tumors; myoepithelium; polycystic ovaries; surgical resection

Received: September 27, 2023; Revised: January 6, 2024; Accepted: January 10, 2024; Prepublished online: February 27, 2024; Published: February 28, 2024  Show citation

ACS AIP APA ASA Harvard Chicago Chicago Notes IEEE ISO690 MLA NLM Turabian Vancouver
Kim S, Baek Y, Park S. Concurrent primary splenic lymphoma and mammary gland tumour with polycystic ovaries in a dog. Vet Med - Czech. 2024;69(2):61-66. doi: 10.17221/99/2023-VETMED.
Share...
Download citation
  • BibTeX (.bib)
  • Bookends (.ris)
  • EasyBib (.ris)
  • EndNote (.enw)
  • EndNote 8 (.xml)
  • ISI WoS (.isi)
  • Medlars (.medlars)
  • Mendeley (.ris)
  • MODS (.xml)
  • Papers (.ris)
  • RefWorks (.txt)
  • RefManager (.ris)
  • RIS (.ris)
  • MS Word (.xml)
  • Zotero (.ris)
    • Open full article

    References

    1. Alonso-Diez A, Ramos A, Roccabianca P, Barreno L, Perez-Alenza MD, Tecilla M, Avallone G, Gama A, Pena L. Canine spindle cell mammary tumor: A retrospective study of 67 cases. Vet Pathol. 2019 Jul;56(4):526-35. Go to original source... Go to PubMed...
    2. Canadas-Sousa A, Santos M, Leal B, Medeiros R, Dias-Pereira P. Estrogen receptors genotypes and canine mammary neoplasia. BMC Vet Res. 2019 Sep 10;15(1):325. Go to original source... Go to PubMed...
    3. Cleveland MJ, Casale S. Incidence of malignancy and outcomes for dogs undergoing splenectomy for incidentally detected nonruptured splenic nodules or masses: 105 cases (2009-2013). J Am Vet Med Assoc. 2016 Jun 1;248(11):1267-73. Go to original source... Go to PubMed...
    4. Gilbertson SR, Kurzman ID, Zachrau RE, Hurvitz AI, Black MM. Canine mammary epithelial neoplasms: Biologic implications of morphologic characteristics assessed in 232 dogs. Vet Pathol. 1983 Mar;20(2):127-42. Go to original source... Go to PubMed...
    5. Goldschmidt M, Pena L, Rasotto R, Zappulli V. Classification and grading of canine mammary tumors. Vet Pathol. 2011 Jan;48(1):117-31. Go to original source... Go to PubMed...
    6. Gray M, Meehan J, Martinez-Perez C, Kay C, Turnbull AK, Morrison LR, Pang LY, Argyle D. Naturally-occurring canine mammary tumors as a translational model for human breast cancer. Front Oncol. 2020 Apr 28;10:617. Go to original source... Go to PubMed...
    7. Hornfeldt MB, Mortensen JK. Surgical dose and the clinical outcome in the treatment of mammary gland tumours in female dogs: A literature review. Acta Vet Scand. 2023 Mar 11;65(1):12. Go to original source... Go to PubMed...
    8. Ito D, Frantz AM, Modiano JF. Canine lymphoma as a comparative model for human non-Hodgkin lymphoma: Recent progress and applications. Vet Immunol Immunopathol. 2014 Jun 15;159(3-4):192-201. Go to original source... Go to PubMed...
    9. Johnston SD, Kustritz MV, Olson PNS. Disorders of the canine ovary. In: Johnston SD, Kustritz MV, Olson PNS, editors. Canine and feline theriogenology. Philadelphia: WB Saunders; 2001. p. 193-205.
    10. Karayannopoulou M, Kaldrymidou E, Constantinidis TC, Dessiris A. Adjuvant post-operative chemotherapy in bitches with mammary cancer. J Vet Med A Physiol Pathol Clin Med. 2001 Mar;48(2):85-96. Go to original source... Go to PubMed...
    11. Knauf Y, Kohler K, Knauf S, Wehrend A. Histological classification of canine ovarian cyst types with reference to medical history. J Vet Sci. 2018 Nov 30;19(6):725-34. Go to original source... Go to PubMed...
    12. Krenacs L, Krenacs T, Stelkovics E, Raffeld M. Heat-induced antigen retrieval for immunohistochemical reactions in routinely processed paraffin sections. Methods Mol Biol. 2010;588:103-19. Go to original source... Go to PubMed...
    13. Misdorp W, Else RW, Hellmee E, Lipscomb TP. Histological classification of mammary tumors of the dog and the cat. Second series. VII. Washington, D.C: WHO, Armed Forces Institute of Pathology, American Registry of Pathology; 1999. p. 45-6.
    14. O'Brien D, Moore PF, Vernau W, Peauroi JR, Rebhun RB, Rodriguez CO Jr, Skorupski KA. Clinical characteristics and outcome in dogs with splenic marginal zone lymphoma. J Vet Intern Med. 2013 Jul-Aug;27(4):949-54. Go to original source... Go to PubMed...
    15. Rasotto R, Berlato D, Goldschmidt MH, Zappulli V. Prognostic significance of canine mammary tumor histologic subtypes: An observational cohort study of 229 cases. Vet Pathol. 2017 Jul;54(4):571-8. Go to original source... Go to PubMed...
    16. Rybicka A, Krol M. Identification and characterization of cancer stem cells in canine mammary tumors. Acta Vet Scand. 2016 Dec 19;58(1):86. Go to original source... Go to PubMed...
    17. Sabattini S, Lopparelli RM, Rigillo A, Giantin M, Renzi A, Matteo C, Capitani O, Dacasto M, Mengoli M, Bettini G. Canine splenic nodular lymphoid lesions: Immunophenotyping, proliferative activity, and clonality assessment. Vet Pathol. 2018 Sep;55(5):645-53. Go to original source... Go to PubMed...
    18. Seelig DM, Avery AC, Ehrhart EJ, Linden MA. The comparative diagnostic features of canine and human lymphoma. Vet Sci. 2016 Jun;3(2):11. Go to original source... Go to PubMed...
    19. Simon D, Schoenrock D, Baumgartner W, Nolte I. Postoperative adjuvant treatment of invasive malignant mammary gland tumors in dogs with doxorubicin and docetaxel. J Vet Intern Med. 2006 Sep-Oct;20(5):1184-90. Go to original source...
    20. Sleeckx N, de Rooster H, Veldhuis Kroeze EJ, Van Ginneken C, Van Brantegem L. Canine mammary tumours, an overview. Reprod Domest Anim. 2011 Dec;46(6):1112-31. Go to original source... Go to PubMed...
    21. van Stee LL, Boston SE, Singh A, Romanelli G, Rubio-Guzman A, Scase TJ. Outcome and prognostic factors for canine splenic lymphoma treated by splenectomy (1995-2011). Vet Surg. 2015 Nov;44(8):976-82. Go to original source... Go to PubMed...

    This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International (CC BY NC 4.0), which permits non-comercial use, distribution, and reproduction in any medium, provided the original publication is properly cited. No use, distribution or reproduction is permitted which does not comply with these terms.


    Return to the content