Vet Med - Czech, 2025, 70(5):177-183 | DOI: 10.17221/88/2024-VETMED

Uterine angiomyofibroblastoma in a domestic cat: A need of precise diagnosis for proper perioperative managementCase Report

TU Kim ORCID...1, JS Park ORCID...2, JH Yim ORCID...1, WJ Kim ORCID...1, SB Hong ORCID...1, YR Jung ORCID...3, SK Choi ORCID...4, SM Baek ORCID...1,5, JK Park ORCID...1,5
1 Department of Veterinary Pathology, College of Veterinary Medicine, Kyungpook National University, Daegu, Republic of Korea
2 Gumi Top Animal Medical Center, Gumi, Republic of Korea
3 Daegu Health College, Department of Companion Animal Health Management, Daegu, Republic of Korea
4 Core Protein Resources Center, Daegu-Gyeongbuk Institute of Science and Technology (DGIST), Daegu, Republic of Korea
5 Institute for Veterinary Biomedical Science, Kyungpook National University, Daegu, Republic of Korea

Angiomyofibroblastoma (AMFB) is rarely reported in humans as well as domestic animals, especially in the female genital tract. This painless tumour is characterised by the proliferation of spindle or ovoid tumour cells with myofibroblastic differentiation, which often cluster around thin-walled blood vessels. This report presents a case of feline AMFB for the first time. Preoperative abdominal radiography demonstrated an enlarged uterus with the dorsolateral displacement of the ovaries, and transabdominal ultrasonography showed an enlarged uterus with diffuse hypoechoic areas. The resected uterus showed a firm texture with a grey to brownish colour. A microscopic examination revealed proliferation of well-differentiated neoplastic spindle cells on a background of abundant fibrous stroma containing numerous blood vessels. Myxoid degeneration and vascular extravasation were not observed. The neoplastic cells were diffusely immunopositive for α-SMA and vimentin and focally positive for desmin (in the perivascular areas). AMFB is rare in veterinary medicine and the feline uterine AMFB observed in the present case had not been previously reported. Although previously reported as a safe, benign tumour, a surgical procedure of a large AMFB in small animals without proper diagnosis may become life-threatening.

Keywords: α-SMA; desmin; feline; hemangiopericytoma; uterus

Received: September 21, 2024; Revised: March 4, 2025; Accepted: March 12, 2025; Prepublished online: May 26, 2025; Published: May 29, 2025  Show citation

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Kim T, Park J, Yim J, Kim W, Hong S, Jung Y, et al.. Uterine angiomyofibroblastoma in a domestic cat: A need of precise diagnosis for proper perioperative management. Vet Med - Czech. 2025;70(5):177-183. doi: 10.17221/88/2024-VETMED.
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