Vet Med - Czech, 2003, 48(12):369-372 | DOI: 10.17221/5792-VETMED

Immunohistochemical localization of calbindin-D28k in the kidney and cerebellum of the porcupines (Hystrix cristata)

S. Timurkaan, A. Aydin, M. Kaban
1 , A. A 2, M. K 2 1Department of Histology-Embryology, 2Department of Anatomy, Faculty of Veterinary Medicine, University of Firat, Elazig, Turkey

The localization of calbindin in the kidney and cerebellum of Hystrix cristata was investigated immu­nohistochemically using an antiserum against the 28k Da calbindin of chicken duodenum. Calbindin-D28k is an intracellular protein with a high affinity for calcium. This protein is exclusively localized in the distal convoluted tubules of the kidney and in Purkinje cells of the cerebellum. Functionaly, calbindin-D28k is supposed to be involved in the regulation of the reabsorption of calcium in the distal nephron, though the exact regulatory mechanisms are not yet known.

Keywords: calbindin-D28k; kidney; cerebellum; Hystrix cristata; immunohistochemist

Published: December 31, 2003  Show citation

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Timurkaan S, Aydin A, Kaban M. Immunohistochemical localization of calbindin-D28k in the kidney and cerebellum of the porcupines (Hystrix cristata). Vet Med - Czech. 2003;48(12):369-372. doi: 10.17221/5792-VETMED.
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