Vet Med - Czech, 2012, 57(7):350-359 | DOI: 10.17221/6263-VETMED

The immunological, biochemical and molecular bases of canine senescence and carcinogenesis: a review

M. Wozna1, B. Kempisty2,3, H. Piotrowska4, J. Dorszewska5, D. Bukowska1, M. Nowicki2
1 Department of Veterinary, Poznan University of Life Sciences, Poznan, Poland
2 Department of Histology and Embryology, Poznan University of Medical Sciences, Poznan, Poland
3 Department of Anatomy, University of Medical Sciences, Poznan, Poland
4 Department of Toxicology, Poznan University of Medical Sciences, Poznan, Poland
5 Department of Neurology, Poznan University of Medical Sciences, Poznan, Poland

Senescence is a complex set of processes involving several biochemical, molecular and metabolomic changes, including also many disturbances in the immunological system. There are many factors, described as intrinsic and extrinsic (environmental), that may lead to advanced body senescence. In this review, several of the biochemical as well as molecular factors involved in senescence are described. The importance of immunological deficiencies as well as changes in the immunological response after induction of senescence is also highlighted. Furthermore, the molecular basis of canine carcinogenesis in relation to interleukin expression and activation as well as the role of CD leukocyte common antigen in the identification of cancer development and progression, are also described.

Keywords: senescence; carcinogenesis; canine

Published: July 31, 2012  Show citation

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Wozna M, Kempisty B, Piotrowska H, Dorszewska J, Bukowska D, Nowicki M. The immunological, biochemical and molecular bases of canine senescence and carcinogenesis: a review. Vet Med - Czech. 2012;57(7):350-359. doi: 10.17221/6263-VETMED.
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