Vet Med - Czech, 2013, 58(1):44-49 | DOI: 10.17221/6657-VETMED

Acute pancreatitis, azotaemia, cholestasis and haemolytic anaemia in a dog: a case reportCase Report

M. Guadarrama-Olhovich, L.E. Garcia Ortuno, J.A. Ruiz Remolina, C. Lopez Buitrago, J. Ramirez Lezama, J. Bouda
Faculty of Veterinary Medicine and Husbandry, National Autonomous University of Mexico, Mexico City, Mexico

We here report acute pancreatitis with multiorganic complications in a female Cocker Spaniel. The most important alterations in clinical pathology were renal azotaemia, hyperbilirubinaemia with a prevalence of conjugated bilirrubin and increased alkaline phosphatase by cholestasis; hyperamylasaemia due to pancreatitis; dehydration, hyponatraemia, hypochloraemia and hypokalaemia related to vomiting; metabolic acidosis and respiratory alkalosis corresponding to mixed acid-base disorder; markedly regenerative anaemia with spherocytes and agglutination due to immune-mediated haemolytic anaemia and intravascular haemolysis; leukocytosis with a left shift. Proteinuria, glucosuria, bilirubinuria and haemoglobinuria were detected in the urine. Severe suppurative pancreatitis with peripancreatic necrosis and suppurative esteatitis, tubulorrhectic nephrosis, severe hepatitis and intrahepatic cholestasis corresponded with alterations described by clinical pathology. In order to diagnose acute pancreatitis in dogs with multiple complications, it is very important to integrate the results of clinical pathology with the anamnesis and physical examination of the animal. It is especially important to note that the serum activity of amylase correlates with time after the pancreatic attack.

Keywords: exocrine pancreas; multiorganic complications; clinical pathology; necropsy; dog

Published: January 31, 2013  Show citation

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Guadarrama-Olhovich M, Garcia Ortuno LE, Ruiz Remolina JA, Lopez Buitrago C, Ramirez Lezama J, Bouda J. Acute pancreatitis, azotaemia, cholestasis and haemolytic anaemia in a dog: a case report. Vet Med - Czech. 2013;58(1):44-49. doi: 10.17221/6657-VETMED.
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    References

    1. Brockus CW, Andreasen CB (2005): Erythrocytes. In: Latimer KS, Mahaffey EA, Prasse KW (eds.): Duncan and Prasse's Veterinary Laboratory Medicine: Clinical Pathology. 4th ed. Blackwell Publishing, Ames. 36-44.
    2. Center SA (2009): Diseases of the gallbladder and biliary tree. Veterinary Clinics of North America Small Animal Practice 39, 543-598. Go to original source... Go to PubMed...
    3. Chan AK (2006): Intermittent pancreatitis in a 2-year-old Chihuahua mixed breed dog. Canadian Veterinary Journal 47, 475-478. Go to original source...
    4. Chantrey J, Chapman PS, Patterson-Kane JC (2002): Haemolytic uraemic syndrome in a dog. Journal of the American Veterinary Medical Association 48, 470-472. Go to original source... Go to PubMed...
    5. Dell'Orco M, Bertazzolo W, Pagilaro L, Roccablanca P, Comazzi S (2005): Haemolytic uraemic syndrome in a dog. Veterinary Clinical Pathology Journal 34, 264-269. Go to original source... Go to PubMed...
    6. Hess RS, Saunders MH, Van Winkle TJ, Shofer FS, Washabau RJ (1998): Clinical, clinicopathologic, radiographic and ultrasound abnormalities in dogs with fatal acute pancreatitis. Journal of American Veterinary Medical Association 213, 665-670.
    7. Hoffmann WE, Solter PF (2008): Diagnostic enzymology of domestic animals. In: Kaneko JJ, Harvey JW, Bruss ML (eds.): Clinical Biochemistry of Domestic Animals. 6th ed. Elsevier, San Diego. 351-378. Go to original source...
    8. Klimes J, Vlasin M, Svobodova V (2000): Diseases of gastrointestinal system and peritoneum. In: Svoboda M, Senior DF, Doubek J, Klimes J (eds.): Diseases of Dog and Cat (in Czech). 1st ed. Noviko, Brno. 659-948.
    9. Newman SJ, Confer AW, Panciera RJ (2007): Urinary system. In: McGavin MD, Zachary JF (eds.): Pathologic Basis of Veterinary Disease. 4th ed. Mosby Elsevier, Philadelphia. 653 pp.
    10. Saif MW (2005): DIC secondary to acute pancreatitis: case report. Clinical Laboratory Hematology 27, 278-282. Go to original source... Go to PubMed...
    11. Shukla A (2010): Acute pancreatitis attributed to dietary indiscretion in a female mixed breed canine. Canadien Veterinary Journal 51, 201-203.
    12. Sinha A, Rai R (2005): Haemolytic uraemic syndrome following acute pancreatitis. Journal of the Pancreas 6, 365-367. Go to PubMed...
    13. Steiner JM (2003): Diagnosis of pancreatitis. Veterinary Clinics of North America Small Animal Practice 33, 1181-1195. Go to original source... Go to PubMed...
    14. Swisher KK, Doan JT, Vesely SK, Kwaan HC, Kim B, Lämmle B, Kremer JA, George JN (2007): Pancreatitis preceding acute episode of thrombotic thrombocytopenic purpura-hemolytic uremic syndrome: report of five patients with a systematic review of published reports. Haematology Journal 92, 936-943. Go to original source... Go to PubMed...
    15. Wang GJ, Gao CF, Wei D, Cun W, Ding SQ (2009): Acute pancreatitis: Etiology and common pathogenesis. World Journal of Gastroenterology 15, 1427-1430. Go to original source... Go to PubMed...
    16. Williams DA, Steiner JM (2005): Exocrine pancreatic disease. In: Ettinger SJ, Feldman EC (eds.): Textbook of Veterinary Internal Medicine, Diseases of Dog and Cat. 6th ed. Elsevier Saunders, Philadelphia. 1482-1487.
    17. Xenolius PG, Suchodolski JS; Steiner JM (2008): Chronic pancreatitis in dogs and cats. Compendium on Continuing Education for the Practicing Veterinarian 30, 166-180.
    18. Zhang XP, Li ZJ (2009): Inflammatory mediators and microcirculatory disturbance in pancreatitis. Hepatobiliary Pancreatic Disease International 8, 351-357.

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