Vet Med - Czech, 2014, 59(10):511-514 | DOI: 10.17221/7783-VETMED

Immunohistochemical characterisation of a canine case of granular cell type trichoblastoma: a case reportCase Report

J.S. Yoon1,2, J. Park3
1 Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea
2 Biomedical Research Center, Seoul National University, Seoul, Republic of Korea
3 College of Veterinary Medicine, Chonbuk National University, Jeonju, Republic of Korea

Herein we describe a case of granular cell type trichoblastoma in a dog. A nine-year-old, intact male Scottish terrier presented with a solitary, exophytic and non-ulcerated nodule on the shoulder. Histopathologically, the nodule showed a ribbon-like structure, which was composed of branching cords of epithelial cells surrounded by fibrous stroma. In addition, islands of large clear cells were also noted. The clear cells showed eccentric nuclei and abundant cytoplasmic vacuoles, which were strongly positive for periodic acid-Schiff staining. Cytoplasmic immunostaining for cytokeratin (CK) 14 and nuclear immunostaining for p63 were observed in the neoplastic cells. In contrast, CK18 staining was scant. Furthermore, the hair bulge stem cell marker CK15 showed strong cytoplasmic staining. Based on these histopathological and immunohistochemical findings, the tumour was diagnosed as a granular cell type trichoblastoma, which is rarely reported in dogs.

Keywords: dog; trichoblastoma; immunohistochemistry; cytokeratin

Published: October 31, 2014  Show citation

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Yoon JS, Park J. Immunohistochemical characterisation of a canine case of granular cell type trichoblastoma: a case report. Vet Med - Czech. 2014;59(10):511-514. doi: 10.17221/7783-VETMED.
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