Vet Med - Czech, 2015, 60(2):109-114 | DOI: 10.17221/7986-VETMED

Computed tomography-guided cementoplasty combined with radiation therapy for an aneurysmal bone cyst in a dog: a case reportCase Report

M. Vignoli1, L. Stehlik2, R. Terragni1, L. Cavallo1, P. Proks2
1 Veterinary Clinic Modena Sud, Spilamberto, Italy
2 Small Animal Clinic, University of Veterinary and Pharmaceutical Sciences Brno, Brno, Czech Republic

Aneurysmal bone cysts are expansile osteolytic bone lesions that can manifest clinically as lameness, pain and swelling. In humans, aneurysmal bone cysts are considered benign tumours that have been classified as primary or secondary to a previous coexisting lesion. Local recurrence after treatment or malignant transformation has been reported in both humans and in a dog. Different treatment options have been proposed. This report describes the treatment of an 11-month-old Irish wolfhound with an aneurysmal bone cyst with a combination of computed tomography-guided cementoplasty and radiation therapy, 30 Gy delivered in 10 fractions. The dog recovered completely, with no lameness observed 30 months after treatment.

Keywords: lameness; CT; benign bone lesion; osteolytic lesion; polymethylmethacrylate

Published: February 28, 2015  Show citation

ACS AIP APA ASA Harvard Chicago Chicago Notes IEEE ISO690 MLA NLM Turabian Vancouver
Vignoli M, Stehlik L, Terragni R, Cavallo L, Proks P. Computed tomography-guided cementoplasty combined with radiation therapy for an aneurysmal bone cyst in a dog: a case report. Vet Med - Czech. 2015;60(2):109-114. doi: 10.17221/7986-VETMED.
Download citation

References

  1. Barnhart MD (2002): Malignant transformation of an aneurysmal bone cyst in a dog. Veterinary Surgery 31, 519-524. Go to original source... Go to PubMed...
  2. Boettcher P, Krastel D, Hierholzer J, Westphalen K, Florian S, Hildebrandt G, Vera G, Oechtering G (2009): Percutaneous cementoplasty in the palliative, multimodal treatment of primary bone tumors of the distal aspect of the radius in four dogs. Veterinary Surgery 38, 888-901. Go to original source... Go to PubMed...
  3. Dernell WS, Erhart NP, Straw RC (2007): Tumors of the skeletal system. In: Withrow V, (ed.): Small Animal Clinical Oncology. 4th ed. Saunders Elsevier. 540-582. Go to original source...
  4. Dowdle SM, Spotswood TC, Lambrechts NE, Duncan NM (2003): Aneurysmal bone cyst in the distal radius of a dog: Diagnostic imaging and surgical treatment. Veterinary and Comparative Orthopaedics and Traumatology 16, 116-121. Go to original source...
  5. Feigenberg SJ, Marcus RB Jr., Zlotecki RA, Scarborough MT, Berrey BH, Enneking WF (2001): Megavoltage radiotherapy for aneurysmal bone cysts. International Journal of Radiation Oncology, Biology, Physics 49, 1243-1247. Go to original source... Go to PubMed...
  6. Halperin EC, Perez CA, Brady LW (2008): The discipline of radiation oncology, radiation-induced second primary malignant tumors. In: Halperin EC, Perez CA, Brady LW (eds.): Principles and Practice of Radiation Oncology. Lippincott Williams & Wilkins, Philadelphia. 54-55.
  7. Hosoya K, Poulson JM, Azuma C (2008): Osteoradionecrosis and radiation induced bone tumors following orthovoltage radiation therapy in dogs. Veterinary Radiology and Ultrasound 49, 189-195. Go to original source... Go to PubMed...
  8. Kyriakos M, Hardy D (1991): Malignant transformation of aneurysmal bone cyst, with an analysis of the literature. Cancer 68, 1770-1780. Go to original source...
  9. Leithner A, Lang S, Windhager R, Leithner K, Karlic H, Kotz R, Haas OA (2001): Expression of insulin-like growth factor-I (IGF-I) in aneurysmal bone cyst. Modern Pathology 14, 1100-1104. Go to original source... Go to PubMed...
  10. Mei J, Gao YS, Wang SQ, Cai XS (2009): Malignant transformation of aneurysmal bone cysts: A case report. Chinese Medical Journal (Engl.) 122, 110-112.
  11. Mendenhall WM, Zlotecki RA, Gibbs CP, Reith JD, Scarborough MT, Mendenhall NP (2006): Aneurysmal bone cyst. American Journal of Clinical Oncology 29, 311-315. Go to original source... Go to PubMed...
  12. Oliveira AM, Hsi BL, Weremowicz S, Rosenberg AE, Dal Cin P, Joseph N, Bridge JA, Perez-Atayde AR, Fletcher JA (2004): Usp6 (tre2) fusion oncogenes in aneurysmal bone cyst. Cancer Research 64, 1920-1923. Go to original source... Go to PubMed...
  13. Oliveira AM, Chou MM, Perez-Atayde AR, Rosenberg AE (2006): Aneurysmal bone cyst: A neoplasm driven by upregulation of the usp6 oncogene. Journal of Clinical Oncology 24, e1; author reply e2. Go to original source... Go to PubMed...
  14. Sarierler M, Cullu E, Yurekli Y, Birincioglu S (2004): Bone cement treatment for aneurysmal bone cyst in a dog. Journal of Veterinary Medical Science 66, 1137-1142. Go to original source... Go to PubMed...
  15. Seegenschmiedt MH (2008): Radiotherapy of nonmalignant diseases. In: Halperin EC, Perez CA, Brady LW (eds.): Principles and Practice of Radiation Oncology. Lippincott Williams & Wilkins, Philadelphia. 1933-1958.
  16. Szendroi M, Arato G, Ezzati A, Huttl K, Szavcsur P (1998): Aneurysmal bone cyst: Its pathogenesis based on angiographic, immunohistochemical and electron microscopic studies. Pathology Oncology Research 4, 277-281. Go to original source... Go to PubMed...
  17. Thrall DE (1984): Orthovoltage radiotherapy of acanthomatous epulides in 39 dogs. Journal of the American Veterinary Medical Association 184, 826-829. Go to original source... Go to PubMed...
  18. Van De Luijtgaarden AC, Veth RP, Slootweg PJ, WijersKoster PM, Schultze Kool LJ, Bovee JV, Van Der Graaf WT (2009): Metastatic potential of an aneurysmal bone cyst. Virchows Archiv 455, 455-459. Go to original source... Go to PubMed...
  19. Vignoli M, Ohlerth S, Rossi F, Pozzi L, Terragni R, Corlazzoli D, Kaser-Hotz B (2004): Computed tomographyguided fine-needle aspiration and tissue-core biopsy of bone lesions in small animals. Veterinary Radiology and Ultrasound 45, 125-130. Go to original source... Go to PubMed...
  20. Vignoli M, Rossi F, Rohrer Bley C, Cancedda S, Leone VF, Laganga P, Stefanello D, Terragni R, Marconato L (2011): Combination of computed tomography-guided cementoplasty and radiation therapy for the treatment of lytic bone lesions in canine extremities. Preliminary Study. In: Proceedings of the European Association of Veterinary Diagnostic Imaging, British Irish Division Autumn Meeting, Cambridge, UK, 45.
  21. Yavuz AA, Sener M, Yavuz MN, Kosucu P, Cobanoglu U (2004): Aneurysmal bone cyst of the sternum: A case report of successful treatment with radiotherapy. British Journal of Radiology 77, 610-614. Go to original source... Go to PubMed...
  22. Ye Y, Pringle LM, Lau AW, Riquelme DN, Wang H, Jiang T, Lev D, Welman A, Blobel GA, Oliveira AM, Chou MM (2010): Tre17/usp6 oncogene translocated in aneurysmal bone cyst induces matrix metalloproteinase production via activation of nf-kappab. Oncogene 29, 3619-3629. Go to original source... Go to PubMed...

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International (CC BY NC 4.0), which permits non-comercial use, distribution, and reproduction in any medium, provided the original publication is properly cited. No use, distribution or reproduction is permitted which does not comply with these terms.