Vet Med - Czech, 2015, 60(2):115-119 | DOI: 10.17221/7987-VETMED

Cutaneous extrarenal rhabdoid tumor in a dog: a case reportCase Report

H.J. Kim1, E.J. Choi1, H.R. Lee1, B.T. Kwon2, S.H. Do1
1 College of Veterinary Medicine, Konkuk University, Seoul, Republic of Korea
2 Taejong Animal Hospital, Busan, Republic of Korea

Rhabdoid tumours (RTs) are rare, highly aggressive tumours of undetermined origin in humans, and are sub-classified as renal/extrarenal RTs depending on location. The origins of extrarenal rhabdoid tumours are an enigma and neoplasms have rarely been reported in non-primate species. An 11-year-old male Maltese dog was presented with a submandibular mass. Histologically, the mass was composed of sheets of highly pleomorphic "rhabdoid" cells, further characterised by the presence of large epithelioid cells with globular/fibrillar paranuclear inclusions. Further immunohistochemical analysis revealed that the neoplastic cells were positive for vimentin and desmin similar to human tumours. In addition, ultrastructural analysis showed that the intracytoplasmic inclusions were mainly composed of whorled bundles of intermediate filaments. Our results suggest a useful diagnostic approach to cutaneous, extrarenal rhabdoid tumours in dogs and describe their characteristics.

Keywords: rhabdoid tumour; cutaneous; cytoplasmic inclusion; vimentin; transmission electron microscopy

Published: February 28, 2015  Show citation

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Kim HJ, Choi EJ, Lee HR, Kwon BT, Do SH. Cutaneous extrarenal rhabdoid tumor in a dog: a case report. Vet Med - Czech. 2015;60(2):115-119. doi: 10.17221/7987-VETMED.
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    References

    1. Beckwith JB, Palmer NF (1978): Histopathology and prognosis of Wilms tumors: results from the First National Wilms' Tumor Study. Cancer 41, 1937-1948. Go to original source...
    2. Biegel JA, Tan L, Zhang F, Wainwright L, Russo P, Rorke LB (2002): Alterations of the hSNF5/INI1 gene in central nervous system atypical teratoid/rhabdoid tumors and renal and extrarenal rhabdoid tumors. Clinical Cancer Research 8, 3461-3467.
    3. Biggs PJ, Garen PD, Powers JM, Garvin AJ (1987): Malignant rhabdoid tumor of the central nervous system. Human Pathology 18, 332-337. Go to original source... Go to PubMed...
    4. Chung JI, Do SH (2009): Rhabdoid tumor in the gluteal region of a Shih-tzu dog. Korean Journal of Veterinary Research 49, 361-363.
    5. Fanburg-Smith JC, Hengge M, Hengge UR, Smith JS Jr, Miettinen M (1998): Extrarenal rhabdoid tumors of soft tissue: a clinicopathologic and immunohistochemical study of 18 cases. Annals of Diagnostic Pathology 2, 351-362. Go to original source... Go to PubMed...
    6. Fujioka M, Hayashida K, Murakami C, Hisaoka M, Oda Y, Ito M (2013): Cutaneous malignant rhabdoid tumor in the palm of an adult. Rare Tumors 5, e36. Go to original source... Go to PubMed...
    7. Haas JE, Palmer NF, Weinberg AG, Beckwith JB (1981): Ultrastructure of malignant rhabdoid tumor of the kidney. A distinctive renal tumor of children. Human Pathology 12, 646-657. Go to original source... Go to PubMed...
    8. Hong CB, Van Meter PW, Latimer CL (1999): Malignant rhabdoid tumour in the orbit of a horse. Journal of Comparative Pathology 121, 197-201. Go to original source... Go to PubMed...
    9. Izawa T, Yamate J, Takeda S, Kumagai D, Kuwamura M (2008): Cutaneous rhabdoid tumor in a cat. Veterinary Pathology 45, 897-900. Go to original source... Go to PubMed...
    10. Kuroda H, Moritake H, Sawada K, Kuwahara Y, Imoto I, Inazawa J, Sugimoto T (2005): Establishment of a cell line from a malignant rhabdoid tumor of the liver lacking the function of two tumor suppressor genes, hSNF5/INI1 end p16. Cancer Genetics and Cytogenetics 158, 172-179. Go to original source... Go to PubMed...
    11. Morgan MB, Stevens L, Patterson J, Tannenbaum M (2000): Cutaneous epithelioid malignant nerve sheath tumor with rhabdoid features: a histologic, immunohistochemical, and ultrastructural study of three cases. Journal of Cutaneous Pathology 27, 529-534. Go to original source... Go to PubMed...
    12. Oda Y, Tsuneyoshi M (2006): Extrarenal rhabdoid tumors of soft tissue: clinicopathological and molecular genetic review and distinction from other soft-tissue sarcomas with rhabdoid features. Pathology International 56, 287-295. Go to original source... Go to PubMed...
    13. Petitt M, Doeden K, Harris A, Bocklage T (2005): Cutaneous extrarenal rhabdoid tumor with myogenic differentiation. Journal of Cutaneous Pathology 32, 690-695. Go to original source... Go to PubMed...
    14. Rorke LB, Packer RJ, Biegel JA (1996): Central nervous system atypical teratoid/rhabdoid tumors of infancy and childhood: definition of an entity. Journal of Neurosurgery 85, 56-65. Go to original source... Go to PubMed...
    15. Schauer G, Moll R, Walter JH., Rumpelt HJ, Goltenboth R (1994): Malignant rhabdoid tumor in the gastric wall of an aged orangutan (Pongo pygmaeus). Veterinary Pathology 31, 510-517. Go to original source... Go to PubMed...
    16. Steele KE, Schulman FY, Mena H, Strimple EO (1997): Rhabdoid tumor in the brain of a dog. Veterinary Pathology 34, 359-363. Go to original source... Go to PubMed...
    17. Tsuneyoshi M, Daimaru Y, Hashimoto H, Enjoji M (1985): Malignant soft tissue neoplasm with histologic features of renal rhabdoid tumors: an ultrastrucural and immunohistochemical study. Human Pathology 16, 1235-1242. Go to original source... Go to PubMed...
    18. Versteege L, Sevenet N, Lange J, Rousseau-Merck MF, Ambros P, Handgretinger R, Aurias A, Delattre O (1998): Truncating mutation of hSNF5/INI1 in aggressive paediatric cancer. Nature 394, 203-206. Go to original source... Go to PubMed...
    19. Weeks DA, Beckwith JB, Mierau GW, Luckey DW (1989): Rhabdoid tumor of kidney. A report of 111 cased from National Wilms' Tumor Study Pathology Center. American Journal of Surgical Pathology 13, 439-458. Go to original source... Go to PubMed...
    20. Wick MR, Ritter JH, Dehner LP (1995): Malignant rhabdoid tumors: a clinicopathologic review and conceptual discussion. Seminars in Diagnostic Pathology 12, 233-248.

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