Vet Med - Czech, 2016, 61(9):533-537 | DOI: 10.17221/43/2016-VETMED

Cutaneous leiomyosarcoma with osteoid metaplasia in a budgerigar (Melopsittacus undulatus): a case reportCase Report

N. Timurkaan, H. Eroksuz, A. Cevik, B. Karabulut
Faculty of Veterinary Medicine, University of Firat, Elazig, Turkey

Cutaneous leiomyosarcoma with osteoid metaplasia was diagnosed at the base of the right wing in a five-year-old female budgerigar. Grossly, the tumour mass was well circumscribed and solitary, and had a nodular appearance on section. On histological examination, the mass was composed of randomly arranged bundles of spindle-shaped cells that included mitotic, multi-nucleated and bizarre cells. In addition, within and between tumour areas, there were osteoid metaplasia foci. The bony trabeculae were usually localised in the areas around the haemorrhage, and exhibited focal mineralisation. Tumour cells were stained red using Masson's trichrome staining method. In addition, tumour cells were intensively positive for smooth muscle actin and focally positive for desmin and vimentin, but were negative for CD68 and S100 by immunohistochemical staining. The tumour reported here was defined as a cutaneous leiomyosarcoma with osteoid metaplasia by histopathological and immunohistochemical findings. Our findings may indicate that osteoid metaplasia should be considered in leiomyosarcoma in budgerigars.

Keywords: desmin; CD68; smooth muscle actin; spindle-shaped cells; S100

Published: September 30, 2016  Show citation

ACS AIP APA ASA Harvard Chicago Chicago Notes IEEE ISO690 MLA NLM Turabian Vancouver
Timurkaan N, Eroksuz H, Cevik A, Karabulut B. Cutaneous leiomyosarcoma with osteoid metaplasia in a budgerigar (Melopsittacus undulatus): a case report. Vet Med - Czech. 2016;61(9):533-537. doi: 10.17221/43/2016-VETMED.
Share...
Download citation
  • BibTeX (.bib)
  • Bookends (.ris)
  • EasyBib (.ris)
  • EndNote (.enw)
  • EndNote 8 (.xml)
  • ISI WoS (.isi)
  • Medlars (.medlars)
  • Mendeley (.ris)
  • MODS (.xml)
  • Papers (.ris)
  • RefWorks (.txt)
  • RefManager (.ris)
  • RIS (.ris)
  • MS Word (.xml)
  • Zotero (.ris)
    • Open full article

    References

    1. Binder SW, Said JW, Shintaku IP, Pinkus GS (1992): A histiocyte-specific marker in the diagnosis of malignant fibrous histiocytoma. Use of monoclonal antibody KP-1 (CD68). American Journal of Clinical Pathology 97, 759-763. Go to original source... Go to PubMed...
    2. Blackmore DK (1966): The clinical approach to tumours in cage birds. The pathology and incidence of neoplasia in cage birds. Journal of Small Animal Practice 6, 217-223. Go to original source... Go to PubMed...
    3. Bush CH, Reith JD, Spanier SS (2003): Mineralization in musculoskeletal leiomyosarcoma: radiologic-pathologic correlation. American Journal of Roentgenology 180, 109-113. Go to original source... Go to PubMed...
    4. Chen E, O'Connell F, Fletcher CD (2011): Dedifferentiated leiomyosarcoma: clinicopathological analysis of 18 cases. Histopathology 59, 1135-1143. Go to original source... Go to PubMed...
    5. Finnie JW, Leong ASY, Milios J (1995): Multiple piloleiomyomas in a cat. Journal of Comparative Pathology 113, 201-204. Go to original source... Go to PubMed...
    6. Grabellus F, Sheu SY, Schmidt B, Flasshove M, Kuhnen C, Ruchholtz S, Taeger G, Schmid KW (2006): Recurrent high-grade leiomyosarcoma with heterologous osteosarcomatous differentiation. Virchows Archives 448, 85-89. Go to original source... Go to PubMed...
    7. Hulland TJ (1990): Tumors of the muscles. In: Moulton JE (ed.): Tumors in Domestic Animals. 3rd edn. University of California Press, Berkeley. 91-92.
    8. Latimer KS (1997): Oncology. In: Ritchie B, Harrison G, Harrison L, Zantop D (eds): Avian Medicine: Principles and Application. 2nd edn. Wingers Publishing, Florida. 640-668.
    9. Lidang JM, Schumacher B, Myhre JO, Steen NO, Keller J (1998): Extraskeletal osteosarcomas: a clinicopathologic study of 25 cases. The American Journal of Surgical Pathology 22, 588-594. Go to original source... Go to PubMed...
    10. Lynch GL, Scagliotti RH (2007): Osseous metaplasia in the eye of a dog. Veterinary Pathology 44, 222-224. Go to original source... Go to PubMed...
    11. Mitchell G (1982): Leiomyosarcoma and perirenal osseous metaplasia in a Rusa hind (Cervus timoriensis). Journal of Wildlife Diseases 18, 95-97. Go to original source... Go to PubMed...
    12. Ohfuji S (2012): Osseous metaplasia in the mesenteric lymph node with metastatic cholangiocarcinoma in a cow. American Journal of Cancer Science 1, 1-7.
    13. Park JK, Lee SK, Park SJ, Hong IH, Jeong KS (2010): Fibroma with osseous metaplasia of external auditory canal in a dog. Journal of Veterinary Diagnostic Investigation 22, 635-638. Go to original source... Go to PubMed...
    14. Reece RL (1992): Observations on naturally occurring neoplasms in birds in the state of Victoria, Australia. Avian Pathology 21, 3-32. Go to original source... Go to PubMed...
    15. Reya T, Morrison SJ, Clarke MF, Wiessman IL (2001): Stem cells, cancer, and cancer stem cells. Nature 414, 105-111. Go to original source... Go to PubMed...
    16. Rottman JB, Roberts MC, Cullen JM (1991): Colonic adenocarcinoma with osseous metaplasia in a horse. Journal of American Veterinary Medical Association 198, 657-659. Go to original source...
    17. Stasik CJ, Tawfik O (2006): Malignant peripheral nerve sheath tumor with rhabdomyosarcomatous differentiation (malignant triton tumor). Archives of Pathology and Laboratory Medicine 130, 1878-1881. Go to original source... Go to PubMed...
    18. Zamani-Ahmadmahmudi M, Nassiri SM, Kkaksar E, Solati AA (2015): A rare case of cutaneous leiomyosarcoma in a budgerigar (Melopsittacus undulatus). Archives of Razi Institute 70, 57-60.

    This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International (CC BY NC 4.0), which permits non-comercial use, distribution, and reproduction in any medium, provided the original publication is properly cited. No use, distribution or reproduction is permitted which does not comply with these terms.


    Return to the content