Vet Med - Czech, 2018, 63(4):187-192 | DOI: 10.17221/152/2017-VETMED

Multiple myeloma associated with IgA lambda gammopathy and multiple myeloma oncogene 1 in a Yorkshire terrierCase Report

S. Kim1, E. Son2, S. Lee2, S. Lee2, H. Kim1, M. Kang1, C. Lee1, H. Park*,1
1 Department of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University, Seoul, Republic of Korea
2 Jeil animal hospital, Seoul, Republic of Korea

An eight-year-old spayed female Yorkshire terrier was presented with a one-month history of conspicuous weight-bearing lameness in the right hindlimb, mild anorexia, intermittent vomiting and marked polydipsia and polyuria. Radiographs revealed circular radiolucent foci of variable size in the skeleton. Haematological and serum biochemistry examination revealed mild leucopoenia with severe neutropaenia, mild non-regenerative anaemia, moderate thrombocytopoenia, moderate hyperglobulinaemia, mild hypoalbuminaemia, mild azotaemia and moderate hypercalcaemia. Quantification of serum immunoglobulins revealed elevated IgA and IgG. Serum protein electrophoresis showed a broad appearance with a β-region spike. Plasma cells accounted for 7.6% of the cells in the bone marrow. Serum immunofixation electrophoresis (IFE) revealed IgA lambda gammopathy. Immunohistochemistry in the bone marrow was diffusely positive for multiple myeloma oncogene 1 (MUM-1) and CD20. To our knowledge, this is first case report of multiple myeloma associated with IgA lambda gammopathy confirmed via IFE and immunohistochemical expression of MUM-1 in a dog.

Keywords: dog; skeletal disease; pain; immunofixation electrophoresis; immunohistochemistry

Published: April 30, 2018  Show citation

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Kim S, Son E, Lee S, Lee S, Kim H, Kang M, et al.. Multiple myeloma associated with IgA lambda gammopathy and multiple myeloma oncogene 1 in a Yorkshire terrier. Vet Med - Czech. 2018;63(4):187-192. doi: 10.17221/152/2017-VETMED.
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    References

    1. Boyle EM, Fouquet G, Guidez S, Bonnet S, Demarquette H, Dulery R, Herbaux C, Noel MP, Manier S, Schraen S, Onraed B, Faucompre J, Hennache B, Petillon MO, Mathiot C, Avet-Loiseau H, Facon TJ, Harding S, Moreau P, Leleu X (2014): IgA kappa/IgA lambda heavy/light chain assessment in the management of patients with IgA myeloma. Cancer 120, 3952-3957. Go to original source... Go to PubMed...
    2. Brunnert SR, Altman NH (1991): Identification of immunoglobulin light chains in canine extramedullary plasmacytomas by thioflavine T and immunohistochemistry. Journal of Veterinary Diagnostic Investigation 3, 245-251. Go to original source... Go to PubMed...
    3. Flory AB, Rassnick KM (2010): Multiple myeloma and plasma cell tumors. In: Cote E (ed.): Clinical Veterinary Advisor: Dogs and Cats. 2nd edn. Elsevier Health Sciences. 730-732.
    4. Giraudel JM, Pages JP, Guelfi JF (2002): Monoclonal gammopathies in the dog: a retrospective study of 18 cases (1986-1999) and literature review. Journal of the American Animal Hospital Association 38, 135-147. Go to original source... Go to PubMed...
    5. Jania B, Andraszek K (2016): Application of native agarose gel electrophoresis of serum proteins in veterinary diagnostics. Journal of Veterinary Research 60, 501-508. Go to original source...
    6. Katzmann JA, Willrich MA, Kohlhagen MC, Kyle RA, Murray DL, Snyder MR, Rajkumar SV, Dispenzieri A (2015): Monitoring IgA multiple myeloma: immunoglobulin heavy/light chain assays. Clinical Chemistry 61, 360-367. Go to original source... Go to PubMed...
    7. Li W, Zhou JZ, Chang HR, Dai LJ, Zhu ZL, Feng YF, Wu DP (2015): Comparison of SPE, IFE, and FLC in monitoring patients with multiple myeloma after autologous stem cell transplantation. Cell Biochemistry and Biophysics 73, 643-647. Go to original source... Go to PubMed...
    8. Patel RT, Caceres A, French AF, McManus PM (2005): Multiple myeloma in 16 cats: a retrospective study. Veterinary Clinical Pathology 34, 341-352. Go to original source... Go to PubMed...
    9. Pusterla N, Stacy BA, Vernau W, De Cock HE, Magdesian KG (2004): Immunoglobulin A monoclonal gammopathy in two horses with multiple myeloma. Veterinary Record 155, 19-23. Go to original source... Go to PubMed...
    10. Rajkumar SV, Dimopoulos MA, Palumbo A, Blade J, Merlini G, Mateos MV, Kumar S, Hillengass J, Kastritis E, Richardson P, Landgren O, Bruno Paiva B, Dispenzieri A, Weiss B, LeLeu X, Zweegman S, Lonial S, Rosinol L, Zamagni E, Jagannath S, Sezer O, Kristinsson SY, Caers J, Usmani SZ, Lahuerta JJ, Johnsen HE, Beksac M, Cavo M, Goldschmidt H, Terpos E, Kyle RA, Anderson KC, Durie BGM, Miguel JFS (2014): International Myeloma Working Group updated criteria for the diagnosis of multiple myeloma. Lancet Oncology 15, e538-e548. Go to original source... Go to PubMed...
    11. Ramos-Vara JA, Miller MA, Valli VEO (2007): Immunohistochemical detection of multiple myeloma 1/interferon regulatory factor 4 (MUM1/IRF-4) in canine plasmacytoma: comparison with CD79a and CD20. Veterinary Pathology 44, 875-884. Go to original source... Go to PubMed...
    12. Seelig DM, Perry JA, Avery AC, Avery PR (2010): Monoclonal gammopathy without hyperglobulinemia in 2 dogs with IgA secretory neoplasms. Veterinary Clinical Pathology 39, 447-453. Go to original source... Go to PubMed...
    13. Sheafor SE, Gamblin RM, Couto CG (1995): Hypercalcemia in two cats with multiple myeloma. Journal of the American Animal Hospital Association 32, 503-508. Go to original source... Go to PubMed...
    14. Sternberg R, Wypij J, Barger AM (2009): Overview of multiple myeloma in dogs and cats. Veterinary Medicine 104, 468-476.
    15. Sukpanichnant S, Cousar JB, Leelasiri A, Graber SE, Greer JP, Collins RD (1994): Diagnostic criteria and histologic grading in multiple myeloma: histologic and immunohistologic analysis of 176 cases with clinical correlation. Human Pathology 25, 308-318. Go to original source... Go to PubMed...
    16. Tripp CD, Bryan JN, Wills TB (2009): Presumptive increase in protein bound serum calcium in a dog with multiple myeloma. Veterinary Clinical Pathology 38, 87-90. Go to original source... Go to PubMed...
    17. Zamora-Ortiz G, Velazquez-Sanchez-de-Cima S, Hernandez-Reyes J, Martagon-Herrera NA, Ruiz-Arguelles A, Ruiz-Delgado GJ, Ruiz-Arguelles GJ (2014): Poor performance of the total kappa/lambda light chain quantification in the diagnosis and follow-up of patients with multiple myeloma. Revista de Investigacion Clinica 66, 314-318.
    18. Zinkl JG, LeCouteur RA, Davis DC, Saunders GK (1983): "Flaming" plasma cells in a dog with IgA multiple myeloma. Veterinary Clinical Pathology 12, 15-19. Go to original source... Go to PubMed...

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