Vet Med - Czech, 2021, 66(9):406-412 | DOI: 10.17221/191/2020-VETMED

Intracranial meningioma in a pet rat: MRI findingsCase Report

C Cococcetta ORCID...1, F Del Signore1, I Cerasoli1, G Di Guardo1, M Baffoni1, G Di Francesco2, V Crocchianti1, M Vignoli1
1 Veterinary Teaching Hospital, University of Teramo, Teramo, Italy
2 Istituto Zooprofilattico Sperimentale dell'Abruzzo e Molise "G. Caporale", Teramo, Italy

We herein report the magnetic resonance imaging (MRI) findings in a brain meningioma in a pet rat (Rattus norvegicus domestica). A 1.5-year-old pet rat was referred for depression, ataxia, tremors and bilateral nystagmus; a brain MRI was elected suspecting an intracranial neoplasia. The study was performed with a 0.25 T scanner. The MRI revealed a well-defined oval mass with a heterogeneous appearance, hyperintense in T1 and T2, and with extra-axial localisation and severe brain compression, the mass appeared strongly and diffusely contrast-enhancing. Euthanasia was elected, with the necropsy confirming the presence of a voluminous extra-axial mass. Histologically, a well-differentiated, benign meningotheliomatous meningioma was diagnosed, with the histochemical stains allowing one to exclude a granular cell tumour. To the best of our knowledge, this is the first report of MRI investigations on a pet rat intracranial meningioma.

Keywords: benign meningotheliomatous meningioma; brain tumour; magnetic resonance imaging; Rattus norvegicus

Received: September 25, 2020; Accepted: April 20, 2021; Published: September 30, 2021  Show citation

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Cococcetta C, Del Signore F, Cerasoli I, Di Guardo G, Baffoni M, Di Francesco G, et al.. Intracranial meningioma in a pet rat: MRI findings. Vet Med - Czech. 2021;66(9):406-412. doi: 10.17221/191/2020-VETMED.
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References

  1. Bentley RT. Magnetic resonance imaging diagnosis of brain tumors in dogs. Vet J. 2015 Aug;205(2):204-16. Go to original source... Go to PubMed...
  2. Breton E, Goetz C, Choquet P, Constantinesco A. Low field magnetic resonance imaging in a rat in vivo. IRBM. 2008 Dec;29(6):366-74. Go to original source...
  3. Chandra M, Riley MG, Johnson DE. Spontaneous neoplasms in aged Sprague-Dawley rats. Arch Toxicol. 1992; 66(7):496-502. Go to original source... Go to PubMed...
  4. Choquet P, Breton E, Goetz C, Marin C, Constantinesco A. Dedicated low-field MRI in mice. Phys Med Biol. 2009 Sep;54(17):5287-99. Go to original source... Go to PubMed...
  5. Dagle GE, Zwicker GM, Renneal RA. Morphology of spontaneous brain tumors in the rat. Vet Pathol. 1979;16(3): 318-24. Go to original source... Go to PubMed...
  6. Graham JP, Newell SM, Voges AK, Roberts GD, Harrison JM. The dural tail sign in the diagnosis of meningiomas. Vet Radiol Ultrasound. 1998 Jul-Aug;39(4):297-302. Go to original source... Go to PubMed...
  7. Hathcock JT. Low field magnetic resonance imaging characteristics of cranial vault meningiomas in 13 dogs. Vet Radiol Ultrasound. 1996 July;37(4):257-63. Go to original source...
  8. Konar M, Lang J. Pros and cons of low-field magnetic resonance imaging in veterinary practice. Vet Radiol Ultrasound. 2011 Mar-Apr;52(Suppl 1):S5-S14. Go to original source... Go to PubMed...
  9. Kraft SL, Gavin PR, DeHaan C, Moore M, Wendling LR, Leathers CW. Retrospective review of 50 canine intracranial tumors evaluated by magnetic resonance imaging. J Vet Intern Med. 1997 Jul-Aug;11(4):218-25. Go to original source... Go to PubMed...
  10. Krinke G, Naylor DC, Schmid S, Frohlich E, Schnider K. The incidence of naturally-occurring primary brain tumours in the laboratory rat. J Comp Pathol. 1985 Apr; 95(2):175-92. Go to original source... Go to PubMed...
  11. McConnell FJ. Brain hemorrhage. In: Wilfried M, editor. Diagnostic MRI in dogs and cats. 1st ed. Boca Raton, FL: CRC Press; 2018. p. 286.
  12. Mitsumori K, Maronpot RR, Boorman GA. Spontaneous tumors of the meninges in rats. Vet Pathol. 1987 Jan; 24(1):50-8. Go to original source... Go to PubMed...
  13. Mitsumori K, Stefanski SA, Maronpot RR. Benign and malignant neoplasms, meninges, rat. In: Jones TC, Mohr U, Hunt RD, editors. Nervous system. Berlin: Springer; 1988. p. 108-17. Go to original source...
  14. Motta L, Mandara MT, Skerritt GC. Canine and feline intracranial meningiomas: An updated review. Vet J. 2012 May;192(2):153-65. Go to original source... Go to PubMed...
  15. Owen MC, Lamb CR, Lu D, Targett MP. Material in the middle ear of dogs having magnetic resonance imaging for investigation of neurologic signs. Vet Radiol Ultrasound. 2004 Mar-Apr;45(2):149-55. Go to original source... Go to PubMed...
  16. Prejean JD, Peckham JC, Casey AE, Griswold DP, Weisburger EK, Weisburger JH. Spontaneous tumors in SpragueDawley rats and Swiss mice. Cancer Res. 1973 Nov;33(11): 2768-73.
  17. Schwarz AJ, Danckaert A, Reese T, Gozzi A, Paxinos G, Watson C, Merlo-Pich EV, Bifone A. A stereotaxic MRI template set for the rat brain with tissue class distribution maps and co-registered anatomical atlas: Application to pharmacological MRI. Neuroimage. 2006 Aug 15;32(2):538-50. Go to original source... Go to PubMed...
  18. Snyder JM, Shofer FS, Van Winkle TJ, Massicotte C. Canine intracranial primary neoplasia: 173 cases (1986-2003). J Vet Intern Med. 2006 May-Jun;20(3):669-75. Go to original source...
  19. Sturges BK, Dickinson PJ, Bollen AW, Koblik PD, Kass PH, Kortz GD, Vernau KM, Knipe MF, Lecouteur RA, Higgins RJ. Magnetic resonance imaging and histological classification of intracranial meningiomas in 112 dogs. J Vet Intern Med. 2008 May-Jun;22(3):586-95. Go to original source... Go to PubMed...
  20. Sumi N, Stavrou D, Frohberg H, Jochmannal G. The incidence of spontaneous tumors of the central nervous system of wistar rats. Arch Toxicol. 1976;35(1):1-13. Go to original source... Go to PubMed...
  21. Summer BA, Cummings JF, DeLahunta A. Tumours of the central nervous system. In: Summer BA, Cummings JF, DeLahunta A, editors. Veterinary neuropathology. St. Louis: Mosby; 1995. p. 351-401.
  22. Troxel MT, Vite CH, Van Winkle TJ, Newton AL, Tiches D, Dayrell-Hart B, Kapatkin AS, Shofer FS, Steinberg SA. Feline intracranial neoplasia: Retrospective review of 160 cases (1985-2001). J Vet Intern Med. 2003 NovDec;17(6):850-9. Go to original source... Go to PubMed...
  23. Troxel MT, Vite CH, Massicotte C, McLear RC, Van Winkle TJ, Glass EN, Tiches D, Dayrell-Hart B. Magnetic resonance imaging features of feline intracranial neoplasia: Retrospective analysis of 46 cats. J Vet Intern Med. 2004 Mar-Apr;18(2):176-89. Go to original source...
  24. Wisner ER, Dickinson PJ, Higgins RJ. Magnetic resonance imaging features of canine intracranial neoplasia. Vet Radiol Ultrasound. 2011 Mar-Apr;52(Suppl 1):S52-61. Go to original source... Go to PubMed...
  25. Wisner ER, Zwingerberger AL. Brain. In: Wisner ER, Zwingerberger AL, editors. Atlas of small animal CT and MRI. Ames: Wiley Blackwell; 2005. p. 153-278.

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