Vet Med - Czech, 2022, 67(9):492-496 | DOI: 10.17221/115/2021-VETMED

Combination of immunosuppressive drugs and allogeneic stem cell treatment in a dog with suspected nephrotic syndromeCase Report

Y Jin, Y Son, T Oh, S Bae ORCID...
Department of Veterinary Internal Medicine, College of Veterinary Medicine, Kyungpook National University, Daegu, Republic of Korea

The case study aims to describe the nephrotic syndrome (NS) in a castrated 3-year-old male Cocker Spaniel dog. The patient arrived at the hospital with a loss of appetite and weakness. Skin oedema with ascites was observed along with hypoalbuminaemia, hypoproteinaemia, hyperlipidaemia, hypercholesterolaemia, and proteinuria (urine protein to creatinine ratio = 22.4). Based on these findings, the patient was diagnosed with NS, although a renal biopsy was not conducted. Prednisolone (1 mg/kg, p.o. q12 h) and mycophenolate mofetil (10 mg/kg, p.o. q12 h) were prescribed as the immunosuppressive drugs, and previously cryopreserved allogeneic adipose tissue-derived mesenchymal stem cells (2 × 107 cells/kg) were injected intravenously. After several weeks of treatment, the patient recovered from NS. This is the first case report on immunosuppressive drugs and allogeneic mesenchymal stem cells being used to treat a dog with NS.

Keywords: dog; glomerular disease; immunosuppressive drug; mesenchymal stem cell; nephrotic syndrome

Received: August 30, 2021; Accepted: April 12, 2022; Prepublished online: July 13, 2022; Published: September 15, 2022  Show citation

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Jin Y, Son Y, Oh T, Bae S. Combination of immunosuppressive drugs and allogeneic stem cell treatment in a dog with suspected nephrotic syndrome. Vet Med - Czech. 2022;67(9):492-496. doi: 10.17221/115/2021-VETMED.
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