Vet Med - Czech, 2024, 69(4):99-114 | DOI: 10.17221/4/2024-VETMED

Mammary neoplasms in female dogs: Clinical, diagnostic and therapeutic aspectsReview

JR Rueda, CD Porto, RP Franco, IB da Costa ORCID..., LMC Bueno, RJS Girio, FFR Manhoso, PCS Bueno, CSF Repetti
Department of Veterinary Science, University of Marilia – UNIMAR, Marilia/SP, Brazil

With the increase in the life expectancy of domestic animals and their increasingly affectionate relationship with their owners, it is possible to observe an increase in cases of neoplasms in these animals. Mammary neoplasia mainly affects older females who have not been castrated, due to hormonal dependence for the development of the tumour. The main form of treatment is surgery. This study aims to carry out an updated review on mammary neoplasms in female dogs covering the anatomy, physiology, prevalence, causes, diagnoses, treatments, prevention and prognosis, based on scientific articles by renowned researchers.

Keywords: dogs; mammary tumour; mammary lump; manual; mammary carcinoma

Received: January 17, 2024; Revised: March 11, 2024; Accepted: March 26, 2024; Published: April 26, 2024  Show citation

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Rueda J, Porto C, Franco R, Costa ID, Bueno L, Girio R, et al.. Mammary neoplasms in female dogs: Clinical, diagnostic and therapeutic aspects. Vet Med - Czech. 2024;69(4):99-114. doi: 10.17221/4/2024-VETMED.
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References

  1. Andrade FH, Figueiroa FC, Bersano PR, Bissacot DZ, Rocha NS. Malignant mammary tumor in female dogs: Environmental contaminants. Diagn Pathol. 2010 Jun 30;5:45. Go to original source... Go to PubMed...
  2. de Araujo MR, Campos LC, Ferreira E, Cassali GD. Quantitation of the regional lymph node metastatic burden and prognosis in malignant mammary tumors of dogs. J Vet Intern Med. 2015 Sep-Oct;29(5):1360-7. Go to original source... Go to PubMed...
  3. Bartels KE, Ferguson HR, Gillete EL, Ferguson HL. Simultaneous bilateral mastectomy in the dog. Vet Surg. 1978;7(4):97-102. Go to original source...
  4. Batschinski K, Tedardi MV. Estadiamento clinico das neoplasias [Clinical staging of neoplasmas]. In: Daleck CR, De Nardi AB. Oncologia em caes e gatos [Oncology in dogs and cats]. 2nd ed. Rio de Janeiro: Roca; 2016. 98 p. Portuguese.
  5. Beauvais W, Cardwell JM, Brodbelt DC. The effect of neutering on the risk of mammary tumours in dogs - A systematic review. J Small Anim Pract. 2012 Jun;53(6):314-22. Go to original source... Go to PubMed...
  6. Beer P, Chiti LE, Nolff MC. The role of sentinel node mapping and lymphadenectomies in veterinary surgical oncology. Lymph. 2023 Jan 10;1(1):2-18. Go to original source...
  7. Belotta AF, Gomes MC, Rocha NS, Melchert A, Giuffrida R, Silva JP, Mamprim MJ. Sonography and sonoelastography in the detection of malignancy in superficial lymph nodes of dogs. J Vet Intern Med. 2019 May;33(3):1403-13. Go to original source... Go to PubMed...
  8. Beserra HEO, Greandi F, Dufloth RM, Pinheiro LGP, Miot HA, Vexenat SCOR, Rocha NS. Metastasis of mammary carcinoma in bitches: Evaluation of the sentinela lymph node technique. Adv Breast Canc Res. 2016 Jan;5(2):58-65. Go to original source...
  9. Bianchi SP, Gomes C, Pavarini SP, Mombach VS, Santos FR, Vieira LC, Oliveira LO, Contesini EA. Linfonodo axilar como sentinela de neoplasia mamaria em cadelas [Axillary lymph node as sentinel of mammary neoplasia in bitch]. Pesq Vet Bras. 2018 Apr;38(4):692-95. Portuguese. Go to original source...
  10. Biondi LR, Gentile LB, Rego AAMS, Noronha NP, Dagli MLZ. Canine mammary tumors in Santos, Brazil: Clinicopathological and survival profile. Braz J Vet Res Anim Sci. 2014;51(3):252-62. Go to original source...
  11. Boston S, Henderson RA Jr. Role of surgery in multimodal cancer therapy for small animals. Vet Clin North Am Small Anim Pract. 2014 Sep;44(5):855-70. Go to original source... Go to PubMed...
  12. Brissot HN, Edery EG. Use of indirect lymphography to identify sentinel lymph node in dogs: A pilot study in 30 tumours. Vet Comp Oncol. 2017 Sep;15(3):740-53. Go to original source... Go to PubMed...
  13. Buitrago F, Uemura G, Sena MCF. Fatores prognosticos em cancer de mama. Comunicacao em Ciencia da Saude [Prognostic factors in breast cancer. Communication in health science]. 2011;22:69-82. Portuguese.
  14. Carvalho MI, Pires I, Prada J, Raposo TP, Gregorio H, Lobo L, Queiroga FL. High COX-2 expression is associated with increased angiogenesis, proliferation and tumoural inflammatory infiltrate in canine malignant mammary tumours: A multivariate survival study. Vet Comp Oncol. 2017 Jun;15(2):619-31. Go to original source... Go to PubMed...
  15. Cassali GD, Lavalle GE, De Nardi AB, Ferreira E, Bertagnolli AC, Estrela-Lima A, Alessi AC, Daleck CR, Salgado BS, Fernandes CG, Sobral RA, Amorim RL, Gamba CO, Damasceno KA, Auler PA, Magalhaes GM, Silva JO, Raposo JB, Ferreira AMR, Oliveira LO, Malm C, Zuccari DAPC, Tanaka NM, Ribeira LR, Campos LC, Souza CM, Leite JS, Soares LMC, Cavalcanti MF, Fonteneles ZGC, Schuch ID, Paniago J, Oliveira TS, Terra EM, Castanheira TLL, Feliz AOC, Carvalho GD, Guim TN, Garrido E, Fernandes SC, Maia FCL, Dagli MLZ, Rocha NS, Fukumasu H, Grandi F, Machado JP, Silva SMMS, Bezerril JE, Frehse MS, Paes de Almeida EC, Campos CB. Consensus for the diagnosis, prognosis and treatment of canine mammary tumours. Braz J Vet Pathol. 2011;4(2):153-80.
  16. Cassali GD, Lavalle GE, Ferreira E, Estrela-Lima A, De Nardi AB, Ghever C, Sobral RA, Amorim RL, Oliveira LO, Sueiro FAR, Beserra HEO, Bertagnolli AC, Gamba CO, Damasceno KA, Campos CB, Araujo MR, Campos LC, Monteiro LN, Nunes FC, Horta RS, Reis DC, Luvizotto MCR, Magalhaes GM, Raposo JB, Ferreira AMR, Tanaka NM, Grandi F, Ubukata R, Batschinski K, Terra EM, Salvador RCL, Jark PC, Delecrodi JER, Nascimento NA, Silva DN, Silva LP, Ferreira KCRS, Frehse MS, Di Santis GW, Silva EO, Guim TN, Kerr B, Cintra PP, Silva FBF, Leite JS, Mello MFV, Ferreira MLG, Fukumasu H, Salgado BS, Torres R. Consensus for the diagnosis, prognosis and treatment of canine mammary tumors - 2013. Braz J Vet Pathol. 2014;7(2):38-69.
  17. Cassali GD, Jark PC, Gamba C, Damasceno KA, Estrela-Lima A, De Nardi AB, Ferreira E, Horta RS, Firmo BF, Sueiro FAR, Rodrigues LCS, Nakagak KYR. Consensus regarding the diagnosis, prognosis and treatment of canine and feline mammary tumors - 2019. Braz J Vet Pathol. 2020;13(3):555-74. Go to original source...
  18. Cavalcanti MF, Cassali GD. Fatores prognosticos no diagnostico clinico e histopatologico dos tumores de mamas em cadelas - Revisao [Prognostic factors in the clinical and histopathological diagnosis of mammary tumors in dogs - Review]. Rev Clin Vet. 2006;11(61):56-63. Portuguese.
  19. Chandler M, Cunningham S, Lund EM, Khanna C, Naramore R, Patel A, Day MJ. Obesity and associated comorbidities in people and companion animals: A one health perspective. J Comp Pathol. 2017 May;156(4):296-309. Go to original source... Go to PubMed...
  20. Cleary MP, Grossmann ME, Ray A. Effect of obesity on breast cancer development. Vet Pathol. 2010 Mar;47(2):202-13. Go to original source... Go to PubMed...
  21. Clemente M, De Andres PJ, Pena L, Perez-Alenza MD. Survival time of dogs with inflammatory mammary cancer treated with palliative therapy alone or palliative therapy plus chemotherapy. Vet Rec. 2009 Jul 18;165(3):78-81. Go to original source... Go to PubMed...
  22. Collivignarelli F, Tamburro R, Aste G, Falerno I, Del Signore F, Simeoni F, Patsikas M, Gianfelici J, Terragni R, Attorri V, Carluccio A, Vignoli M. Lymphatic drainage mapping with indirect lymphography for canine mammary tumors. Animals (Basel). 2021 Apr 13;11(4):1115. Go to original source... Go to PubMed...
  23. Cooley DM, Beranek BC, Schlittler DL, Glickman NW, Glickman LT, Waters DJ. Endogenous gonadal hormone exposure and bone sarcoma risk. Cancer Epidemiol Biomarkers Prev. 2002 Nov;11(11):1434-40.
  24. Cotran RS, Kumar V, Robbins SL. Patologia estrutural e funcional [Structural and functional pathology]. 6th ed. Rio de Janeiro: Guanabara Koogan; 2000. 1400 p. Portuguese.
  25. De Nardi AB, Daleck CR, Amorin RL, Huppes RR, Uscategui RAR, Rodaski S, Calderon C, Neto RT. Expresion de la ciclooxigenasa-2 en los carcinomas mamarios caninos primarios metastasicos y no metastasicos [Cyclooxigenase-2 expression in primary metastatic and non metastatic canine mammarian carcinomas]. Arch Med Vet. 2013;45(3):311-6. Spanish. Go to original source...
  26. De Nardi AB, Ferreira TMMR, Assuncao KA. Neoplasias mamarias [Mammary neoplasms]. In: Daleck CR, De Nardi AB, editors. Oncologia em caes e gatos [Oncology in dogs and cats]. 2nd ed. Rio de Janeiro: Roca; 2016. 730 p. Portuguese.
  27. de Oliveira Gamba C, Scaratti D, de Andrade VP, Estrela-Lima A, Ferreira E, Cassali GD. Invasive micropapillary carcinoma of the mammary gland in humans and canines: Clinicopathological, immunophenotypical and survival approaches. Res Vet Sci. 2017 Dec;115:189-94. Go to original source... Go to PubMed...
  28. Dore M, Lanthier I, Sirois J. Cyclooxygenase-2 expression in canine mammary tumors. Vet Pathol. 2003 Mar;40(2):207-12. Go to original source... Go to PubMed...
  29. Dobson JM, Lascelles BDX. BSAVA manual of canine and feline oncology. Quedgeley, Gloucester: British Small Animal Veterinary Association; 2011. 364 p.
  30. Dyce KM, Sack WO, Wensing CJG. Tratado de anatomia veterinaria [Treated of veterinary anatomy]. 4th ed. Rio de Janeiro: Elsevier; 2010. 813 p. Portuguese.
  31. Estrela-Lima A, Araujo MS, Costa-Neto JM, Teixeira-Carvalho A, Barrouin-Melo SM, Cardoso SV, Martins-Filho OA, Serakides R, Cassali GD. Immunophenotypic features of tumor infiltrating lymphocytes from mammary carcinomas in female dogs associated with prognostic factors and survival rates. BMC Cancer. 2010 Jun 4;10:256. Go to original source... Go to PubMed...
  32. Ferreira E, Bertagnolli AC, Cavalcanti MF, Schmitt FC, Cassali GD. The relationship between tumour size and expression of prognostic markers in benign and malignant canine mammary tumours. Vet Comp Oncol. 2009 Dec;7(4):230-5. Go to original source... Go to PubMed...
  33. Getty R. Anatomia dos animais domesticos [Anatomy of domestics animals]. 5th ed. Rio de Janeiro: Guanabara Koogan; 2008. 2052 p. Portuguese.
  34. Giuliano AE, Hunt KK, Ballman KV, Beitsch PD, Whitworth PW, Blumencranz PW, Leitch AM, Saha S, McCall LM, Morrow M. Axillary dissection vs no axillary dissection in women with invasive breast cancer and sentinel node metastasis: A randomized clinical trial. JAMA. 2011 Feb 9;305(6):569-75. Go to original source... Go to PubMed...
  35. Goldschmidt M, Pena L, Rasotto R, Zappulli V. Classification and grading of canine mammary tumors. Vet Pathol. 2011 Jan;48(1):117-31. Go to original source... Go to PubMed...
  36. Goldschmidt M, Pena L, Zappulli V. Tumours of the mammary gland. In: Meuton DJ, editor. Tumours in domestic animals. 5th ed. Ames, Iowa: John Wiley & Sons; 2017. p. 723-65. Go to original source...
  37. Gregorio H, Prada J, Queiroga FL, Lobo L. Use of Firocoxib alone or in combination with metronomic Chlorambucil doses in macroscopic unresectable cancers in dogs. In: Proceedings of the European Society of Veterinary Oncology annual meeting; May 30th - Jun 1st 2013; Lisbon; 2013. p. 62.
  38. Guimaraes MJ, Carvalho MI, Pires I, Prada J, Gil AG, Lopes C, Queiroga FL. Concurrent expression of cyclo-oxygenase-2 and epidermal growth factor receptor in canine malignant mammary tumours. J Comp Pathol. 2014 Jan;150(1):27-34. Go to original source... Go to PubMed...
  39. Hart BL, Hart LA, Thigpen AP, Willits NH. Assisting decision-making on age of neutering for mixed breed dogs of five weight categories: Associated joint disorders and cancers. Front Vet Sci. 2020a Jul 31;7:472. Go to original source... Go to PubMed...
  40. Hart BL, Hart LA, Thigpen AP, Willits NH. Assisting decision-making on age of neutering for 35 breeds of dogs: Associated joint disorders, cancers, and urinary incontinence. Front Vet Sci. 2020b Jul 7;7:388. Go to original source... Go to PubMed...
  41. Henderson BE, Feigelson HS. Hormonal carcinogenesis. Carcinogenesis. 2000 Mar;21(3):427-33. Go to original source... Go to PubMed...
  42. Horta RS, Costa MP, Lavalle RB, Cassali GD. Fatores prognosticos e preditivos dos tumores caninos definidos com o auxilio da imuno-histoquimica [Prognostic and predictive factors of canine tumours defined with immunohistochemistry's assistance]. Cienc Rural. 2012 Jun;42(6):1033-9. Portuguese. Go to original source...
  43. Horta RS, Lavall GE, Castro Cunha RM, Moura LL, Araujo RB, Cassali GD. Influence of surgical technique on overall survival, disease free interval and new lesion development interval in dogs with mammary tumors. Adv Breast Canc Res. 2014 Apr;3(2):38-46. Go to original source...
  44. Horta RS, Figueiredo MS, Lavalle GE, Costa MP, Cunha RM, Araujo RB. Surgical stress and postoperative complications related to regional and radical mastectomy in dogs. Acta Vet Scand. 2015 Jun 24;57(1):34. Go to original source... Go to PubMed...
  45. Humphrey LL, Helfand M, Chan BK, Woolf SH. Breast cancer screening: A summary of the evidence for the U.S. Preventive Services Task Force. Ann Intern Med. 2002 Sep 3;137(5 Part 1):347-60. Go to original source... Go to PubMed...
  46. Kamiguchi IE, Moreira IM, Silva Trindade F, Zahn A, Sousa Rocha N. Mammary neoplasms in female dogs: Identification of cytopathological criteria for malignancy. J Cytol Histol. 2016;7(1):1-5.
  47. Karayannopoulou M, Lafioniatis S. Recent advances on canine mammary cancer chemotherapy: A review of studies from 2000 to date. Rev Med Vet. 2016 Aug;167(7/8):192-200.
  48. Kaszak I, Ruszczak A, Kanafa S, Kacprzak K, Krol M, Jurka P. Current biomarkers of canine mammary tumors. Acta Vet Scand. 2018 Oct 29;60(1):66. Go to original source... Go to PubMed...
  49. Kim NH, Lim HY, Im KS, Shin JI, Kim HW, Sur JH. Evaluation of clinicopathological characteristics and oestrogen receptor gene expression in oestrogen receptor-negative, progesterone receptor-positive canine mammary carcinomas. J Comp Pathol. 2014 Jul;151(1):42-50. Go to original source... Go to PubMed...
  50. Kristiansen VM, Pena L, Diez Cordova L, Illera JC, Skjerve E, Breen AM, Cofone MA, Langeland M, Teige J, Goldschmidt M, Sorenmo KU. Effect of ovariohysterectomy at the time of tumor removal in dogs with mammary carcinomas: A randomized controlled trial. J Vet Intern Med. 2016 Jan-Feb;30(1):230-41. Go to original source... Go to PubMed...
  51. Lana SE, Rutteman GR, Withrow SJ. Tumors of the mammary gland. In: Withrow SJ, Vail DM, editors. Withrow and MacEwen's Small animal clinical oncology. 4th ed. St. Louis: Saunders Elsevier; 2007. p. 619-38. Go to original source...
  52. Lavalle GE, Bertagnolli AC, Tavares WL, Cassali GD. Cox-2 expression in canine mammary carcinomas: Correlation with angiogenesis and overall survival. Vet Pathol. 2009 Nov;46(6):1275-80. Go to original source... Go to PubMed...
  53. Lavalle GE, De Campos CB, Bertagnolli AC, Cassali GD. Canine malignant mammary gland neoplasms with advanced clinical staging treated with carboplatin and cyclooxygenase inhibitors. In Vivo. 2012 May-Jun;26(3):375-9.
  54. Lim HY, Im KS, Kim NH, Kim HW, Shin JI, Yhee JY, Sur JH. Effects of obesity and obesity-related molecules on canine mammary gland tumors. Vet Pathol. 2015 Nov;52(6):1045-51. Go to original source... Go to PubMed...
  55. Litterine-Kaufman J, Casale SA, Mouser PJ. Prevalence of malignancy in masses from the mammary gland region of dogs with single or multiple masses. J Am Vet Med Assoc. 2019 Oct 1;255(7):817-20. Go to original source... Go to PubMed...
  56. Majeski SA, Steffey MA, Fuller M, Hunt GB, Mayhew PD, Pollard RE. Indirect computed tomographic lymphography for iliosacral lymphatic mapping in a cohort of dogs with anal sac gland adenocarcinoma: Technique description. Vet Radiol Ultrasound. 2017 May;58(3):295-303. Go to original source... Go to PubMed...
  57. Marconato L, Romanelli G, Stefanello D, Giacoboni C, Bonfanti U, Bettini G, Finotello R, Verganti S, Valenti P, Ciaramella L, Zini E. Prognostic factors for dogs with mammary inflammatory carcinoma: 43 cases (2003-2008). J Am Vet Med Assoc. 2009 Oct 15;235(8):967-72. Go to original source... Go to PubMed...
  58. Martins LR, Lopes MD. Pseudociese canina [Canine pseudociesis]. Rev Bras Reprod Anim. 2005;29(3/4):137-41. Portuguese. Go to original source...
  59. Matos AJ, Baptista CS, Gartner MF, Rutteman GR. Prognostic studies of canine and feline mammary tumours: The need for standardized procedures. Vet J. 2012 Jul;193(1):24-31. Go to original source... Go to PubMed...
  60. Maues T, Israel CB, Ferreira MLG, Ferreira AMR. Uso do corante azul de metileno a 2% na localizacao do linfonodo axilar em cadelas (Canis familiaris - Linnaeus, 1758) [Use of 2% methylene blue dye forlocation of axillary lymph node in bitches (Canis familiaris - Linnaeus, 1758)]. Braz J Vet Res Anim Sci. 2016;53(1):32-8. Portuguese. Go to original source...
  61. Millanta F, Asproni P, Canale A, Citi S, Poli A. COX-2, mPGES-1 and EP2 receptor immunohistochemical expression in canine and feline malignant mammary tumours. Vet Comp Oncol. 2016 Sep;14(3):270-80. Go to original source... Go to PubMed...
  62. Misdorp W. Tumors of the mammary gland. In: Meuten DJ, editor. Tumors in domestic animals. Iowa State: University of California; 2002. p. 575-606. Go to original source...
  63. Monteiro GA, Novaes JR, Carvalho Junior JD, Rio JA, Ribeiro LLS, Silva LP, Silva MV, Pereira NLL, Faria RA, Kerner YG, Neves NMBC. O dilema da decisao da mastectomia bilateral como prevencao do cancer de mama: Aspectos eticos e bioeticos [The dilemma of the decision of bilateral mastectomy as breast cancer preventive procedure: Ethical and bioethical aspects]. Bioethicos. 2011;5(4):443-50. Portuguese.
  64. Mohr A, Luder Ripoli F, Hammer SC, Willenbrock S, Hewicker-Trautwein M, Kielbowicz Z, Murua Escobar H, Nolte I. Hormone receptor expression analyses in neoplastic and non-neoplastic canine mammary tissue by a bead based multiplex branched DNA assay: A gene expression study in fresh frozen and formalin-fixed, paraffin-embedded samples. PLoS One. 2016 Sep 20;11(9):e0163311. Go to original source... Go to PubMed...
  65. Moulton JE. Tumors of the mammary gland. In: Moulton JE, editor. Tumors in domestic animals. 3rd ed. Los Angeles: University of California Press; 1990. p. 518-52.
  66. Nagata WB, Perri SHV, Eugenio FR, Laranjeira MG, Andrade AL. Perfil epidemiologico da neoplasia mamaria canina em Aracatuba: Uma abordagem estatistica [Epidemiological profile of canine mammary neoplasia in Aracatuba: A statistical approach]. Rev Estat (UFOP). 2014;3(3):669-73. Portuguese.
  67. Novosad CA. Principios de tratamento de tumores da glandula mamaria [Principles of treatment for mammary gland tumors]. Clin Tech Small Anim Pract. 2003 May;18(2):107-9. Portuguese. Go to original source... Go to PubMed...
  68. Nowak M, Madej JA, Pula B, Dziegiel P, Ciaputa R. Expression of matrix metalloproteinase 2 (MMP-2), E-cadherin and Ki-67 in metastatic and non-metastatic canine mammary carcinomas. Ir Vet J. 2016 Aug 2;69:9. Go to original source... Go to PubMed...
  69. Nunes FC, Gamba CO, Damasceno KA, Campos CB, Horta RS, Araujo MR, Monteiro LN, Lavalle GE, Ferreira E, Cassali GD. Analysis of clinico-pathological data, therapeutical conduct and overall survival of canine mammary lesions attended at the veterinary hospital of the Federal University of Minas Gerais (UFMG). Braz J Vet Pathol. 2014 Jul;7(2):122-6.
  70. Nunes FC, Campos CB, Teixeira SV, Bertagnolli AC, Lavalle GE, Cassali GD. Epidemiological, clinical and pathological evaluation of overall survival in canines with mammary neoplasms. Arq Bras Med Vet Zootec. 2018 Nov-Dec;70(6):1714-22. Go to original source...
  71. Nunes FC, Damasceno KA, de Campos CB, Bertagnolli AC, Lavalle GE, Cassali GD. Mixed tumors of the canine mammary glands: Evaluation of prognostic factors, treatment, and overall survival. Vet Anim Sci. 2019 Sep 22;7:100039. Erratum in: Vet Anim Sci. 2020 Mar 21;9:100109. Erratum in: Vet Anim Sci. 2020 Dec 9;11:100156. Go to original source... Go to PubMed...
  72. Oliveira Filho JC, Kommers GD, Masuda EK, Marques BMFPP, Fighera RA, Irigoyen LF, Barros SL. Estudo retrospectivo de 1 647 tumores mamarios em caes [Retrospective study of 1 647 mammary gland tumors in dogs]. Pesq Vet Bras. 2010;30(2):177-85. Portuguese. Go to original source...
  73. Oliveira BC, Rosso GS, Sartor MD, Souza FC, Cardoso E. Vantagens do rastreamento precoce de metastases por tomografia computadorizada na rotina clinica oncologica de tumores mamarios em cadelas: Revisao de literatura [Advantages of early metastasis screening by computed tomography in the clinical oncology routine of breast tumors in bitches: Literature review]. Rev Educ Contin Med Vet Zootec. CRMV-SP. 2021;19(1):1-13. Portuguese. Go to original source...
  74. Papazoglou LG, Basdani E, Rabidi S, Patsikas MN, Karagiannopolou M. Current surgical options for mammary tumor removal in dogs. J Veter Sci Med. 2014 Feb;2(1):1-5. Go to original source...
  75. Paulinelli RR, Freitas-Junior R, Rahal RM, Oliveira LF, Vilela MH, Moreira MA, Alves KL, Peleja MB, Resende TC. A prospective randomized trial comparing patent blue and methylene blue for the detection of the sentinel lymph node in breast cancer patients. Rev Assoc Med Bras (1992). 2017 Feb;63(2):118-23. Go to original source... Go to PubMed...
  76. Paz WA, Paim SP, Mello GL. Biopsia de linfonodo sentinela: Experiencia clinica [Sentinel lymph node biopsy: Clinical experience]. Rev Bras Cancerol. 2001 Sep;47(3):309-15. Portuguese. Go to original source...
  77. Pena L, Silvan G, Perez-Alenza MD, Nieto A, Illera JC. Steroid hormone profile of canine inflammatory mammary carcinoma: A preliminary study. J Steroid Biochem Mol Biol. 2003 Feb;84(2-3):211-6. Go to original source... Go to PubMed...
  78. Pereira CT, Luiz Navarro Marques F, Williams J, Wlademir De Martin B, Primo Bombonato P. 99mTc-labeled dextran for mammary lymphoscintigraphy in dogs. Vet Radiol Ultrasound. 2008 Sep-Oct;49(5):487-91. Go to original source... Go to PubMed...
  79. Perez Alenza MD, Tabanera E, Pena L. Inflammatory mammary carcinoma in dogs: 33 cases (1995-1999). J Am Vet Med Assoc. 2001 Oct 15;219(8):1110-4. Go to original source... Go to PubMed...
  80. Pinheiro LGP, Moraes MO, Soares AH, Lopes AJT, Naguere MASP, Gondim FAL, Brandao CB, Nascimento DCH, Soares JPH, Meneses e Silva JM. Estudo experimental de linfonodo sentinela na mama da cadela com azul patente e tecnecio Tc99m [Experimental study of the sentinel lymph node in the dog breast using blue dye and technetium Tc99m]. Acta Cir Bras. 2003 Dec;18(6):545-52. Portuguese. Go to original source...
  81. Queiroga F, Lopes CC. Tumores mamarios caninos: Novas perspectivas [Canine mammary tumors: New perspectives]. In: Congresso de Ciências Veterinárias [Proceedings of the Veterinary Sciences Congress]; 2002 Oct 10-12; Lisboa: Sociedade Portuguesa de Ciências Veterinárias; 2002. p. 183-90. Portuguese.
  82. Queiroga FL, Pires I, Lobo L, Lopes CS. The role of Cox-2 expression in the prognosis of dogs with malignant mammary tumours. Res Vet Sci. 2010 Jun;88(3):441-5. Go to original source... Go to PubMed...
  83. Ramos-Vara JA, Kiupel M, Baszler T, Bliven L, Brodersen B, Chelack B, Czub S, Del Piero F, Dial S, Ehrhart EJ, Graham T, Manning L, Paulsen D, Valli VE, West K; American Association of Veterinary Laboratory Diagnosticians Subcommittee on Standardization of Immunohistochemistry. Suggested guidelines for immunohistochemical techniques in veterinary diagnostic laboratories. J Vet Diagn Invest. 2008 Jul;20(4):393-413. Go to original source... Go to PubMed...
  84. Raposo TP, Arias-Pulido H, Chaher N, Fiering SN, Argyle DJ, Prada J, Pires I, Queiroga FL. Comparative aspects of canine and human inflammatory breast cancer. Semin Oncol. 2017 Aug;44(4):288-300. Go to original source... Go to PubMed...
  85. Reese S, Budras KD, Mulling C, Bragulla H, Konig HE. Glandula mamaria (mamma, uber, mastos) [Mammary gland (mamma, uber, mastos)]. In: Konig HE, Liebich HG, editors. Anatomia dos animais domesticos [Anatomy of domestics animals]. 4th ed. Porto Alegre: Artmed; 2011. 787 p. Portuguese.
  86. Reis FR, Barreira APB, Castro V, Castro JLC, Suzano SMC, Rocha A. Indicios sobre a correlacao entre diferentes metodos diagnosticos em casos de tumor de mama em cadelas [Evidence about correlation of breast bitch tumor casesand different methods diagnostic]. Rev Eletro Novo Enfoque. 2010;9(9):14-31. Portuguese.
  87. Ribas CR, Dornbusch PT, Faria MR, Wouk AFPF, Cirio SM. Alteracoes clinicas relevantes em cadelas com neoplasias mamarias estadiadas [Relevant clinical changes in female dogs with mammary neoplasias staged]. Arch Vet Sci. 2012;17(1):60-8. Portuguese. Go to original source...
  88. Riva GT, Hart BL, Farver TB, Oberbauer AM, Messam LL, Willits N, Hart LA. Neutering dogs: Effects on joint disorders and cancers in golden retrievers. PLoS One. 2013;8(2):e55937. Go to original source... Go to PubMed...
  89. Rossi F, Korner M, Suarez J, Carozzi G, Meier VS, Roos M, Rohrer Bley C. Computed tomographic-lymphography as a complementary technique for lymph node staging in dogs with malignant tumors of various sites. Vet Radiol Ultrasound. 2018 Mar;59(2):155-62. Go to original source... Go to PubMed...
  90. Rutteman G, Withrow S, MacEwen EG. Tumors of the mammary gland. In: Withrow SJ, MacEwen E, editors. Small animal clinical oncology. 3rd ed. Philadelphia: WB Saunders; 2001. p. 455-77.
  91. Silva AE, Serakides R, Cassali GD. Carcinogenese hormonal e neoplasias hormonio-dependentes [Hormonal carcinogenesis and hormone-dependent neoplasms]. Cienc Rural. 2004 Mar-Apr;34(2):625-33. Portuguese. Go to original source...
  92. Sirivaidyapong S. Dogs with mammary gland tumors and the feeding dietary types. In: Proceedings of 28th World Congress of the World Small Animal Veterinary Association; 2003 Oct 24-27; Bangkok, Thailand; 2003.
  93. Sorenmo KU, Rasotto R, Zappulli V, Goldschmidt MH. Development, anatomy, histology, lymphatic drainage, clinical features, and cell differentiation markers of canine mammary gland neoplasms. Vet Pathol. 2011 Jan;48(1):85-97. Go to original source... Go to PubMed...
  94. Sorenmo KU, Worley DR, Goldschmidt MH. Tumors of the mammary gland. In: Withrow SJ, Vail DM, Page RP, editors. Small animal clinical oncology. 5th ed. Philadelphia: Saunders Company; 2013. p. 538-56. Go to original source...
  95. Sorenmo K, Worley D, Zappulli V. Tumors of the mammary gland. In: Vail D, Thamm, D, Liptack J, editors. Small animal clinical oncology. 6th ed. St. Louis, MO: Elsevier; 2020. p. 604-25. Go to original source...
  96. Suryawanshi RV. Assessment of efficacy and toxicity of cyclophosphamide chemotherapy in canines with malignant mammary tumor: A retrospective study. Vet Med Int. 2021 Aug 12;2021:5520603. Go to original source... Go to PubMed...
  97. Toribio JMML, Estrela-Lima A, Martins Filho EF, Ribeiro LGR, D'Assis MJMH, Teixeira RG, Damasceno KA, Cassali GD, Costa Neto JM. Caracterizacao clinica, diagnostico histopatologico e distribuicao geografica das neoplasias mamarias em cadelas de Salvador, Bahia [Clinical characterization, histopathologic diagnosis and geoprocessing of mammary tumours in bitches from the city of Salvador, Bahia State]. Rev Ceres. 2012 Jul-Aug;59(4):427-33. Portuguese. Go to original source...
  98. Tuohy JL, Milgram J, Worley DR, Dernell WS. A review of sentinel lymph node evaluation and the need for its incorporation into veterinary oncology. Vet Comp Oncol. 2009 Jun;7(2):81-91. Go to original source... Go to PubMed...
  99. Uva P, Aurisicchio L, Watters J, Loboda A, Kulkarni A, Castle J, Palombo F, Viti V, Mesiti G, Zappulli V, Marconato L, Abramo F, Ciliberto G, Lahm A, La Monica N, de Rinaldis E. Comparative expression pathway analysis of human and canine mammary tumors. BMC Genomics. 2009 Mar 27;10:135. Go to original source... Go to PubMed...
  100. Valdivia G, Alonso-Diez A, Perez-Alenza D, Pena L. From conventional to precision therapy in canine mammary cancer: A comprehensive review. Front Vet Sci. 2021 Feb 17;8:623800. Go to original source... Go to PubMed...
  101. Withrow SJ, Page R, Vail, DM. Withrow and MacEwen's Small animal clinical oncology. St. Louis: Elsevier Health Sciences; 2014. 750 p.
  102. Worley DR. Incorporation of sentinel lymph node mapping in dogs with mast cell tumours: 20 consecutive procedures. Vet Comp Oncol. 2014 Sep;12(3):215-26. Go to original source... Go to PubMed...
  103. Zatloukal J, Lorenzova J, Tichy F, Necas A, Kecova H, Kohout P. Breed and age as risk factors for canine mammary tumours. Acta Vet Brno. 2005;74:103-9. Go to original source...

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