Vet Med - Czech, 2024, 69(10):345-354 | DOI: 10.17221/49/2024-VETMED

Evaluation of coagulation by thromboelastography and a velocity curve in dogs with parvoviral enteritisOriginal Paper

O Eralp Inan ORCID...1, P Levent ORCID...3, A Saril ORCID...3, L Hamabe ORCID...2, M Kocaturk ORCID...3, Z Yilmaz ORCID...3
1 Department of Animal Science, Faculty of Agriculture, Eskisehir Osmangazi Univesity, Eskisehir, Turkey
2 Department of Veterinary Medicine, Facility of Agriculture, Tokyo University of Agriculture and Technology, Fuchu, Japan
3 Department of Internal Medicine, Faculty of Veterinary Medicine, Bursa Uludag University, Bursa, Turkey

Canine parvoviral enteritis (CPE) has a high mortality rate in untreated dogs due to systemic inflammation and multi-organ dysfunction. The inflammatory process can lead to coagulation abnormalities. This study aimed to evaluate the coagulation status using thromboelastography (TEG) and assess the thrombin generation (TG) and clot dissolution using TEG-derived velocity curve (v-curve) parameters in dogs with CPE. It included 21 dogs with CPE and five healthy dogs. In addition to the clinico-haemato-biochemical examinations, the coagulation status was analysed using citrated venous blood samples with TEG. All the dogs with CPE met at least two criteria for systemic inflammatory response syndrome (SIRS). The comparison to healthy controls showed a statistically significant prolongation of reaction times (R time; P = 0.005) and times to the maximum rate of thrombus generation (TMRTG; P = 0.003). However, the times to the maximum rate of lysis (TMRL; P = 0.041) and total lysis (L; P = 0.024) decreased significantly. The TEG tracings showed coagulation states varying from hypocoagulation to hypercoagulation in dogs with CPE. These results showed that the v-curve derivate can be used to evaluate the coagulation in dogs with CPE, and it could be superior to the standard TEG variables for determining the low fibrinolytic activity. Thus, the v-curve parameters may provide a novel insight into the underlying mechanism and clinical treatment strategy of CPE-induced inflammation.

Keywords: coagulation; fibrinolysis; hypercoagulation; hypocoagulation; inflammation; sepsis

Received: June 7, 2024; Revised: October 4, 2024; Accepted: October 4, 2024; Prepublished online: October 30, 2024; Published: October 31, 2024  Show citation

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Eralp Inan O, Levent P, Saril A, Hamabe L, Kocaturk M, Yilmaz Z. Evaluation of coagulation by thromboelastography and a velocity curve in dogs with parvoviral enteritis. Vet Med - Czech. 2024;69(10):345-354. doi: 10.17221/49/2024-VETMED.
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