Vet Med - Czech, 2026, 71(2):73-81 | DOI: 10.17221/26/2025-VETMED

Ocular squamous cell carcinoma (OSCC) in a female buffaloCase Report

R Batista Viana ORCID...1, A Araujo Borges Lima ORCID...1, JM de Sousa Soares1, G Meireles Borges1, D Araujo Marques ORCID...2, SM da Silva Lobato ORCID...1, D de Menezes Melo ORCID...1, JC Melem Santos1, L do Socorro Bremgarter1, PE Zezema ORCID...3, S da Gama Barbosa Monger3, G Melo Alves dos Santos ORCID...4, PP Maia Teixeira ORCID...4, G Rodrigues Galvao1, J Dantas Ribeiro Filho ORCID...5, B Moura Monteiro ORCID...1
1 Federal Rural University of the Amazon, Belém, PA, Brazil
2 Federal Institute of Education, Science and Technology of Amazonas, Manaus, AM, Brazil
3 Evandro Chagas Institute, Belém, PA, Brazil
4 Federal University of Pará, Castanhal, PA, Brazil
5 Federal University of Viçosa, Viçosa, MG, Brazil

Ocular squamous cell carcinoma (OSCC) is an epithelial neoplasm that affects the ocular and periocular tissues, often associated with factors such as exposure to ultraviolet radiation. The disease is rarely reported in buffalo, particularly regarding its progression and treatment. This report describes a case of a buffalo with a pink mass in the right eye showing signs of inflammation. After clinical examination and initial treatment with topical solutions and systemic drugs, the tumour continued to grow. As a result, surgery was performed to remove the mass while preserving the eyeball and third eyelid. The procedure was successful, and histopathological analysis confirmed the diagnosis of OSCC. Postoperative recovery was satisfactory. It was concluded that early surgical treatment followed by medical treatment allowed complete recovery in the buffalo with OSCC.

Keywords: Amazonia; buffaloes; eye; ocular neoplasia

Received: April 7, 2025; Revised: August 25, 2025; Accepted: August 26, 2025; Published: February 27, 2026  Show citation

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Batista Viana R, Araujo Borges Lima A, JM de Sousa S, Meireles Borges G, Araujo Marques D, SM da Silva L, et al.. Ocular squamous cell carcinoma (OSCC) in a female buffalo. Veterinární medicína. 2026;71(2):73-81. doi: 10.17221/26/2025-VETMED.
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    References

    1. Anderson DE, Badzioch M. Association between solar radiation and ocular squamous cell carcinoma in cattle. Am J Vet Res. 1991 May;52(5):784-8. Go to original source...
    2. Barros RR, Rech RR, Viott AM, Barros CSL. Carcinoma de celulas escamosas no olho de bovino com invasao cerebral atraves dos nervos cranianos [Ocular squamous cell carcinoma in a cow with cerebral invasion through cranial nerves]. Ciencia Rural. 2006 Sep;36(5):1651-4. Portuguese. Go to original source...
    3. Carvalho T, Vala H, Pinto C, Pinho M, Peleteiro MC. Immunohistochemical studies of epithelial cell proliferation and p53 mutation in bovine ocular squamous cell carcinoma. Vet Pathol. 2005 Jan;42(1):66-73. Go to original source... Go to PubMed...
    4. Castro SRS, Rebelo LS, Junior OSF, Belo-Reis AS, Neves KAL, Silva WC, Morini AC, Vale WG. Influence of seasonality on the physiological and seminal parameters of buffaloes in the western region of Para. Pesqui Vet Bras. 2020 Dec;40(12):1048-53. Go to original source...
    5. Chahory S, Clerc B, Devauchelle P, Tnibar A. Treatment of a recurrent ocular squamous cell carcinoma in a horse with Iridium-192 implantation. J Equine Vet Sci. 2002 Nov;22(11):503-6. Go to original source...
    6. Costa RA, Schild C, Caffarena D, Giannitti F, Banchero G, DelpPio L, Riet-Correa F. High frequency of cutaneous squamous cell carcinoma in Friesian Milchschaf sheep in Uruguay. Pesqui Vet Bras. 2019 Apr;39(4):98-109. Go to original source...
    7. Dariva F, Valduga PC, Lira AL, Colet R, Ruzycki JF, Setim DH, Almeida MA, Backes GT, Oliveira DS. Carcinoma indiferenciado metastatico em bovino leiteiro: Relato de caso [Dairy cattle undifferentiated metastatic carcinoma: A case report]. Rev Persp. 2021 Oct;45(171):15-23. Portuguese. Go to original source...
    8. Devi VR, Veeraiah G, Annaourna P, Estheru S. Squamous cell carcinoma of ear in an Indian water buffalo (Bubalus bubalis). Braz J Vet Pathol. 2010 Feb;3(1):60-2.
    9. Dubielzig RR. Tumors of the eye. In: Meuten DJ, editor. Tumors of domestic animals. 4th ed. Iowa: Iowa State Press; 2002. p. 739-54. Go to original source...
    10. Islam ST, Khurma J, Wani JM, Ganaie MY, Singh AK, Rashid H, Fayaz IB. Ocular squamous cell carcinoma in a female buffalo: A case report. J Entomol Zool Stud. 2017 Nov;5(6):795-6.
    11. Krishna NVVH, Sreenu M, Nagaraju N. Squamous cell carcinoma of eye in buffaloes - A report of two cases. Buffalo Bull. 2020 Sep;39(3):395-400.
    12. Kuma KM, Sharif NM. Surgical management of ocular squamous cell carcinoma in buffaloes: A report of 4 cases. J Entomol Zool Stud. 2018 Mar;6(2):402-4.
    13. Nithya P, Balasubramaniam GA, Arulmozhi A, Gopalakrishnamurthy TR, Kathirvel S. Factors influencing the occurrence of ocular neoplasms in cattle and buffaloes. Pharma Innov. 2022 Dec;11(12):3043-6.
    14. Oliveira MC. Neoplasias em animais de producao diagnosticadas no Setor de Anatomia Patologica da UFRRJ no período de 1947 a 2019 [Neoplasms in production animals diagnosed in the Department of Pathological Anatomy of UFRRJ from 1947 to 2019] [dissertation]. Seropédica (Brazil): Universidade Federal Rural do Rio de Janeiro; 2020. Portuguese.
    15. Pires APC. Estudo das enfermidades de animais de producao no estado do Para, diagnosticadas no Setor de Anatomia Patologica da Universidade Federal Rural do Rio de Janeiro, no periodo de 1997 a 2017 [Study of diseases of production animals in the state of Para, diagnosed at the Pathological Anatomy Sector of the Federal Rural University of Rio de Janeiro, from 1997 to 2017] [dissertation]. Seropédica (Brazil): Universidade Federal Rural do Rio de Janeiro; 2018. Portuguese.
    16. Quevedo DAC, Oliva CAC, Bravo NL, Hernandez DR. Estudio clinico, histopatologico e inmunohistoquimico del carcinoma de celulas escamosas ocular bovino en el departamento de Narino, Colombia [Clinical, histopathological and immunohistochemical study of bovine ocular squamous cell carcinoma in the Narino department, Colombia]. Rev Investig Vet Peru. 2020 Oct;(4):251-4. Spanish.
    17. Ramos AT, Norte DM, Elias F, Fernandes CG. Carcinoma de celulas escamosas em bovinos, ovinos e equinos: Estudo de 50 casos no sul do Rio Grande do Sul [Squamous cell carcinoma in cattle, sheep and horse: Study of 50 cases in south of Rio Grande do Sul]. Braz J Vet Res Anim Sci. 2007 Jun;44:5-13. Portuguese. Go to original source...
    18. Regmi S, Regmi S, Lamichhane U, Bista S, Tiwary AK. A case report of squamous cell carcinoma in buffalo. Int J Vet Sci Anim Husb. 2018 Oct;3(6):5-7.
    19. Reis MO, Slaviero M, Lorenzett MP, Cruz RAS, Guimaraes LLB, Pavarini SP, Driemeier D, Sonne L. Neoplasmas bovinos diagnosticados no Setor de Patologia Veterinaria da UFRGS, Porto Alegre (2005-2014) [Bovine neoplasms diagnosed in the Sector of Veterinary Pathology of UFRGS, Porto Alegre, Brazil (2005-2014)]. Pesqui Vet Bras. 2017 Feb;37(2):105-9. Portuguese. Go to original source...
    20. Rizzo H, Carvalho JS, Hora JHC, Febronio AMB. Tratamento clinico-cirurgico de carcinoma de celulas escamosas vulvar em bovinos do Estado de Sergipe [Surgical treatment of vulvar squamous cell carcinoma in cattle in the State of Sergipe]. Sci Plena. 2015 Apr;11(4):1-6. Portuguese.
    21. Santos RL, Alessi AC. Patologia veterinaria [veterinary Pathology]. 2nd ed. São Paulo: Roca; 2016. 856 p. Portuguese.
    22. Soares MS, Caldeira FHB, Fracasso IO, Araujo KC. Carcinoma de celulas escamosas em conjuntiva ocular de bovino - Relato de caso [Squamous cell carcinoma of the ocular conjunctiva in cattle - Case report]. Rev Ibero-Am Humanid Cienc Educ. 2023 Jan;9(1):428-36. Portuguese. Go to original source...
    23. Srivastav A, Shyama NP, Singh R, Gangwar NK. Ocular squamous cell carcinoma in a buffalo. J Indian Vet Assoc. 2022 Mar;20(3):112-6. Go to original source...
    24. Tessele B, Barros CSL. Tumores em bovinos encontrados em abatedouros frigorificos [Tumours found in cattle from slaughterhouse]. Pesqui Vet Bras. 2016 Mar;36(3):145-60. Portuguese. Go to original source...

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