Vet Med - Czech, 2002, 47(7):199-210 | DOI: 10.17221/5824-VETMED
Clinical endocrinology of thyroid gland function in ruminants
- Faculty of Veterinary Science, Szent István University, Budapest, Hungary
After briefly introducing the basec steps in production and metabolism of thyroid hormones, the author gives an overview of nutritional, metabolic and disease related factors and endocrine interactions influencing thyroid gland function in ruminants, particularly in the postpartum dairy cow. Involvement of thyroid hormonal regulation of seasonal patterns of reproduction as well as ovarian endocrine function are discussed.
Keywords: thyroxin; triiodothyronine; ovary; metabolism; ruminants
Published: July 31, 2002 Show citation
References
- Amstalden M., Garcia M.R., Williams S.W., Stanko R.L., Nizielski S.E., Morrison C.D., Keisler D.H., Williams G.L. (2000): Leptin gene expression, circulating leptin, and luteinizing hormone pulsatility are acutely responsive to short-term fasting in heifers: relationships to circulating insulin and insulin-like growth factor-I. Biol. Reprod., 63, 127-133.
Go to original source...
Go to PubMed...
- Awadeh F.T., Kincaid, R.L., Johnson, K.A. (1998): Effect of level and source of dietary selenium on concentrations of thyroid hormones and immunoglobulins in beef cows and calves. J. Anim. Sci., 76, 1204-1215.
Go to original source...
Go to PubMed...
- Bandyopadhyay A., Roy P., Bhattacharya S. (1996): Thyroid hormone induces the synthesis of a putative protein in the rat granulosa cell which stimulates progesterone release. J. Endocrinol., 150, 309-318.
Go to original source...
Go to PubMed...
- Barb C.R. (1999): The brain-pituitary-adipocyte axis: role of leptin in modulating neuroendocrine function. J. Anim. Sci., 77, 1249-1257.
Go to original source...
Go to PubMed...
- Barb C.R., Barrett J.B., Krealing, R.R., Rampacek, G.B. (1999): Role of leptin in modulating neuroendocrine function: a metabolic link between the brain, pituitary and adipose tissue. Reprod. Domest. Anim., 34, 111-125.
Go to original source...
- Bartalena L.F., Bogazzi F., Brogioni S., Grasso L., Martino, E. (1998): Role of cytokines in the pathogenesis of the euthyroid sick syndrome. Eur. J. Endocrinol., 138, 603-614.
Go to original source...
Go to PubMed...
- Berczi I. (1993): Neuroendocrine defense in endotoxin shock. Acta Microbiol. Hung., 40, 265-302.
Go to PubMed...
- Bernal A., De'Moraes G.V., Thrift T.A., Willard, C.C., Randel, R.D. (1999): Effects of induced hypothyroidism on ovarian response to superovulation in Brahman (Bos indicus) cows. J. Anim. Sci., 77, 2749-2756.
Go to original source...
Go to PubMed...
- Bitman J., Kahl S., Wood, D.L., Lefcourt A.M. (1994): Circadian and ultradian rhythms of plasma thyroid hormone concentrations in lactating dairy cows. Am. J. Physiol., 266, R1797-R1803.
Go to original source...
Go to PubMed...
- Block S.S., Butler W.R., Ehrhardt R.A., Bell A.W., Van Amburg M.E., Boisclair Y.R. (2001): Decreased concentration of plasma leptin in periparturient dairy cows is caused by negative energy balance. J. Endocrinol., 171, 341-50.
Go to original source...
Go to PubMed...
- Bocquier F., Bonnet M., Faulconnier Y., Guerre-Millo M., Martin P., Chilliard, Y. (1998): Effects of photoperiod and feeding level on perirenal adipose tissue metabolic activity and leptin synthesis in the ovariectomized ewe. Reprod. Nutr. Dev., 38, 489-498.
Go to original source...
Go to PubMed...
- Browning R., Leite-Browning M.L., Smith H.M., Wakefield T. (1998): Effect of ergotamine and ergonovine on plasma concentrations of thyroid hormones and cortisol in cattle. J. Anim. Sci., 76, 1644-1650.
Go to original source...
Go to PubMed...
- Browning R, Gissendanner S.J., Wakefield T. (2000): Ergotamine alters plasma concentrations of glucagon, insulin, cortisol, and triiodothyronine in cows. J. Anim. Sci., 78, 690-698.
Go to original source...
Go to PubMed...
- Bunting L.D., Fernandez J.M., Fornea R.J., White T.W., Froetschel M.A., Stone J.D., Ingawa K. (1996): Seasonal effects of supplemental fat or undegradable protein on the growth and metabolism of Holstein calves. J. Dairy. Sci., 79, 1611-1620.
Go to original source...
Go to PubMed...
- Capuco A.V., Keys J.E., Smith J.J. (1989): Somatotrophin increases thyroxine-5-mono-iodinase activity in lactating mammary tissue of the cow. J. Endocrinol., 121, 205-211.
Go to original source...
Go to PubMed...
- Capuco A.V., Wood D.L., Elsasser T.H., Kahl S., Erdman R.A., Van Tassell, C.P., Lefcourt, A., Piperova, L.S. (2001): Effect of somatotropin on thyroid hormones and cytokines in lactating dairy cows during ad libitum and restricted feed intake. J. Dairy Sci., 84, 2430-2439.
Go to original source...
Go to PubMed...
- Cassar-Malek I., Kahl S., Jurie C., Picard C. (2001): Influence of feeding level during postweaning growth on circulating concentrations of thyroid hormones and extrathyroidal 5'-deiodination in steers. J. Anim. Sci., 79, 2679-2687.
Go to original source...
Go to PubMed...
- Chan W.K., Tan C.H. (1986): Inhibition of folliclestimulating hormone induction of aromatase activity in porcine granulosa cells by thyroxin and triiodothyronine. Endocrinology, 119, 2353-2359.
Go to original source...
Go to PubMed...
- Channing C.P., Tsai V., Sachs D. (1976): Role of insulin, thyroxin and cortisol in luteinization of porcine granulosa cells grown in chemically defined media. Biol. Reprod., 15, 235-247.
Go to original source...
Go to PubMed...
- Charrier J., Martal J. (1988): Growth hormones. 1. Polymorphism (minireview). Reprod. Nutr. Dev., 28, 857-887.
Go to original source...
Go to PubMed...
- Chilliard Y., Bocquier F., Delavaud C., Guerre-Millo M., Bonnet M., Martin P., Faulconnier Y., Ferlay, A. (1998): Leptin in ruminants: effects of species, breed, adiposity, photoperiod, Th-agonists and nutritional status. Proc. Cornell Nutrition Conference for Feed Manufacturers (Rochester Marriott Thruway Hotel, Rochester, NY), The Cornell University, pp. 65-74.
- Chilliard Y., Bonnet M., Delavaud C., Faulconnier Y., Leroux C., Djiane J., Bocquier F. (2001): Leptin in ruminants. Gene expression in adipose tissue and mammary gland, and regulation of plasma concentration. Domest. Anim. Endocrinol., 21, 271-295.
Go to original source...
Go to PubMed...
- Considine R.V., Caro J.F. (1997): Leptin and the regulation of body weight. Internat. J. Biochem. Cell Biol., 29, 1255-1272.
Go to original source...
Go to PubMed...
- Dahl G.E., Evans N.P., Moenter S.M., Karsch F.J. (1994): The thyroid gland is required for reproductive neuroendocrine responses to photoperiod in the ewe. Endocrinology, 135, 10-15.
Go to original source...
Go to PubMed...
- Dahl G.E., Evans N.P., Thrun L.A., Karsch F.J. (1995): Thyroxin is permissive to seasonal transition in reproductive neuroendocrine activity in the ewe. Biol. Reprod., 52, 690-696.
Go to original source...
Go to PubMed...
- Datta M., Roy P., Banerjee J., Bhattacharya S. (1998): Thyroid hormone stimulates progesterone release from human luteal cells by generating a proteinaceous factor. J. Endocrinol., 158, 319-325.
Go to original source...
Go to PubMed...
- Delavaud C., Bocquier F., Chilliard Y., Keisler D.H., Gertler, A., Kann, G. (2000): Plasma leptin determination in ruminants: effect of nutritional status and body fatness on plasma leptin concentrations assessed by a specific RIA in sheep. J. Endocrinol., 165, 519-526.
Go to original source...
Go to PubMed...
- Delavaud C., Ferlay A., Faulconnier Y., Bocquier F., Kann G., Chilliard Y. (2002): Plasma leptin concentration in adult cattle: effects of breed, adiposity, feeding level, and meal intake. J. Anim. Sci., 80, 1317-1328.
Go to original source...
Go to PubMed...
- De'Moraes G.V., Vera-Avila H.R., Lewis A.W., Koch J.W., Neuendorff D.A., Hallford D.M., Reeves J.J., Randel R.D. (1998): Influence of hypo- or hyperthyroidism on ovarian function in Brahman cows. J. Anim. Sci., 76, 871-876.
Go to original source...
Go to PubMed...
- Dickson W.M. (1990): Endocrine glands. In: Swenson M.J. (ed.): Dukes' Physiology of Domestic Animals. Tenth edition. Cornell University Press, Ithaca, pp. 761-797.
- Ehrhardt R.A., Slepetis R.M., Siegal-Willott J., Van Amburgh M.E., Bell A.W., Boisclair Y.R. (2000): Development of a specific radioimmunoassay to measure physiological changes of circulating leptin in cattle and sheep. J. Endocrinol., 166, 519-528.
Go to original source...
Go to PubMed...
- Eppinga M., Suriyasathaporn W., Kulcsar M., Huszenicza Gy., Wensing T., Dieleman S.J. (1999): Thyroxin and triiodothyronine in association with milk yield, ThOHbutyrate, and non-esterified fatty acid during the peak of lactation. Abstract. J. Dairy Sci., 82 (Suppl.), 50.
- Fitzgerald B.P., Davison L.A. (1998): Thyroxin concentrations are elevated in mares which continue to exhibit estrous cycles during the nonbreeding season. J. Equine Vet. Sci., 18, 48-51.
Go to original source...
- Flier J.F., Harris M., Hollenberg A.N. (2000): Leptin, nutrition and the thyroid: the why, the wherefore, and the wiring. J. Clin. Invest., 105, 859-861.
Go to original source...
Go to PubMed...
- Foster D.L., Nagatani S. (1999): Physiological perspectives on leptin as a regulator of reproduction: role in timing puberty. Biol. Reprod., 60, 205-215.
Go to original source...
Go to PubMed...
- Friedman J.M, Halaas J.L. (1998): Leptin and the regulation of body weight in mammals. Nature, 395, 763-770.
Go to original source...
Go to PubMed...
- Gennano-Soffietti M., Nebbia C., Biolatti B., Re G., Castagnaro M., Cottino F., Guarda, F. (1988): Toxicology of fungicides: effects of 270 days administration of zinc-ethylene-bis-dithiocarbamate in Friesian cattle. Schweiz. Arch. Tierheilk, 130, 657-672.
- Goldman S.M., Dirnfeld H., Abramovici H., Kraiem Z. (1993): Triiodothyronine (T3) modulates hCG-regulated progesterone secretion, cAMP accumulation and DNA content in cultured human luteinized granulosa cells. Mol. Cell. Endocrinol., 96, 125-131.
Go to original source...
Go to PubMed...
- Gregoraszczuk E.L., Skalka M. (1996): Thyroid hormone as a regulator of basal and human chorionic gonadotropin-stimulated steroidogenesis by cultured porcine theca and granulosa cells isolated at different stages of the follicular phase. Reprod. Fertil. Dev., 8, 961-967.
Go to original source...
Go to PubMed...
- Gregoraszczuk E.L., Slomczynska M., Wilk R. (1998): Thyroid hormone inhibits aromatase activity in porcine thecal cells cultured alone and in coculture with granulosa cells. Thyroid, 8, 1157-1163.
Go to original source...
Go to PubMed...
- Grochowska R., Sorensen P., Zwierzchowski L., Snochowski M., Lovendahl P. (2001): Genetic variation in stimulated GH release and in IGF-I of young dairy cattle and their associations with the leucine/valine polymorphism in the GH gene. J. Anim. Sci., 79, 470-476.
Go to original source...
Go to PubMed...
- Haastaren van G.A.C., Meer van der M.J.M., Hermus A.R.M.M., Linkels E., Klootwijk W., Kaptein E., Toor van H., Sweep C.G.J., Visser T.J., Greef de W.J. (1994): Different effects of continuous infusion of IL-1 and IL-6 on the hypothalamic-hypophyseal-thyroid axis. Endocrinology, 135, 1336-1345.
Go to original source...
Go to PubMed...
- Hashimoto H., Igarashi N., Miyawaki T., Sato T. (1995): Effects of TNF-Th, IL-1Th, and IL-6 on type-I iodothyronine 5'-deiodination in rat thyroid cell line, FRTL-5. J. Interfer. Cytokin Res., 15, 367-375.
Go to original source...
Go to PubMed...
- Hayashi M., Maruo T., Matsuo H., Mochizuki M. (1985): The biocellular effect of thyroid hormone on functional differentiation of porcine granulosa cells in culture. Nippon Naibunpi Gakkai Zasshi, 61, 1189-1196.
Go to original source...
Go to PubMed...
- Hoshino S, Wakita M, Kobayashi Y, Sakauchi R, Nishiguchi Y, Ozawa A, Hodate K, Hamaguchi I, Yotani Y. (1991): Variations in serum levels of insulinlike growth factor-I, growth hormone and thyroid hormones during lactation in dairy cows. Comp. Biochem. Physiol., 99A, 61-64.
Go to original source...
Go to PubMed...
- Houseknecht K.L., Portocarrero C.P. (1998): Leptin and its receptors: regulators of whole-body energy homeostasis. Domest. Anim. Endocrin., 15, 457-475.
Go to original source...
Go to PubMed...
- Houseknecht K.L., Baile C.A., Matteri R.L., Spurlock M.E. (1998): The biology of leptin: a review. J. Anim. Sci., 76, 1405-1420.
Go to original source...
Go to PubMed...
- Hurley W.L., Convey E.M., Leung K., Edgerton L.A., Hemken R.W. (1981): Bovine prolactin, TSH, T4 and T3 concentrations as affected by tall fescue summer toxicosis and temperature. J. Anim. Sci., 51, 374-379.
Go to original source...
Go to PubMed...
- Huszenicza Gy., Fodor M., Gacs M., Kulcsar M., Dohmen M.J.V., Vamos M., Porkolab L., Kegl T., Bartyik J., Lohuis J.A.C.M., Janosi Sz., Szita G. (1999): Uterine bacteriology, resumption of cyclic ovarian activity and fertility in postpartum cows kept in large-scale dairy herds. Reprod. Domest. Anim., 34, 237-245.
Go to original source...
- Ingvartsen K.L., Boisclair Y.R. (2001): Leptin and the regulation of food intake, energy homeostasis and immunity with special focus on periparturient ruminants. Domest. Anim. Endocrinol., 21, 215-250.
Go to original source...
Go to PubMed...
- Johnson H.D., Li R., Manalu W., Spencer-Johnson K.J., Becker B.A., Collier R.J., Baile C.A. (1991): Effects of somatotropin on milk yield and physiological responses during summer farm and hot laboratory conditions. J. Dairy Sci., 74, 1250-1262.
Go to original source...
Go to PubMed...
- Kadokawa H., Blache D., Yamada Y., Martin, G.B. (2000): Relationships between changes in plasma concentrations of leptin before and after parturition and the timing of first post-partum ovulation in highproducing Holstein dairy cows. Reprod. Fertil. Dev., 12, 405-411.
Go to original source...
Go to PubMed...
- Kahl S., Capuco A.V., Binelli M., Wanderkooi W.K., Tucker H.A., Mosely W.M. (1995): Comparison of growth hormone releasing factor and somatotropin: thyroid status of lactating, primiparous cows. J. Dairy Sci., 78, 2150-2158.
Go to original source...
Go to PubMed...
- Kahl S., Elsasser T.H., Blum J.W. (2000): Effect of endotoxin challenge on hepatic 5'-deiodinase activity in cattle. Domest. Anim. Endocrinol., 18, 133-143.
Go to original source...
Go to PubMed...
- Kansaku N., Aggrey S.E., Gollapudi B.A.S., Kuhnlein U., Zadworny D. (2000): Mixed model analysis of markers in growth hormone and its receptor and their association with lactational performance in Holsteins. In: SSR Meeting, Madison, USA, Abstract: 491.
- Kaplan M.M. (1986): Regulatory influences on iodothyronine deiodination in animal tissues. In: Hennemann G. (ed.): Thyroid Hormone Metabolism. M. Dekker Inc., New York, USA. 231-253.
- Keisler D.H., Daniel J.A., Morrison S.D (1999): The role of leptin in nutritional status and reproductive function. J. Reprod. Fertil. 54 (Suppl.), 425-435.
- Kesler D.J., Johnson H.D., Garverick H.A. (1981): Postpartum concentrations of thyroxin in plasma of dairy cows. J. Dairy Sci., 64, 1618-1620.
Go to original source...
Go to PubMed...
- Leonard J.L., Visser T.J. (1986): Biochemistry of deiodination. In: Hennemann G. (ed.): Thyroid Hormone Metabolism. M. Dekker Inc., New York, USA. 189-229.
- Leyva-Ocariz H., Lucciola K., Puzzar S. (1997): Serum thyroid hormone concentrations during growth and puberty in Carora dairy heifers of Venezuela. Theriogenology, 48, 19-31.
Go to original source...
Go to PubMed...
- Lohuis J.A.C.M., Verheijden J.H.M., Burvenich C., Miert van A.S.J.P.A.M. (1988): Pathophysiological effects of endotoxin in ruminants. 2. Metabolic aspects. Vet. Quart., 10, 117-125.
Go to original source...
Go to PubMed...
- Lowe J.E., Foote R.H., Baldwin B.H., Hillman R.B. Kallfelz F.A. (1987): Reproductive patterns in cyclic and pregnant thyroidectomized mares. J. Reprod. Fertil., 35 (Suppl.), 281-288.
Go to PubMed...
- Lucy M.C., Hauser S.D., Eppard P.J., Krivi G.G., Clark J.H., Bauman D.E., Collier R.J. (1993): Variants of somatotropin in cattle: gene frequencies in major dairy breeds and associated milk production. Domest. Anim. Endocrinol., 10, 325-333.
Go to original source...
Go to PubMed...
- Maruo T., Hayashi M., Matsuo H., Yamamoto T., Okada H., Mochizuki M. (1987): The role of thyroid hormone as a biological amplifier of the actions of follicle-stimulating hormone in the functional differentiation of cultured porcine granulosa cells. Endocrinology, 121, 1233-1241.
Go to original source...
Go to PubMed...
- Maruo T., Hiramatsu S., Otani T., Hayashi M., Mochizuki M. (1992): Increase in the expression of thyroid hormone receptors in porcine granulosa cells in follicular maturation. Acta Endocrinol., 127, 152-160.
Go to original source...
Go to PubMed...
- Mattheij J.A., Swarts J.J., Lokerse P., van Kampen J.T., Van der Heide D. (1995): Effect of hypothyroidism on the pituitary-gonadal axis in the adult female rat. J. Endocrinol., 146, 87-94.
Go to original source...
Go to PubMed...
- McGuire M.A., Beede D.K., Collier R.J., Buonomo F.C., DeLorenzo M.A., Wilcox. C.J. (1991): Effects of acute thermal stress and amount of feed intake on concentrations of somatotropin insulin-like growth factor (IGF)-I and IGF-II, and thyroid hormones in plasma of lactating Holstein cows. J. Anim. Sci., 69, 2050-2056.
Go to original source...
Go to PubMed...
- Moenter S.M., Woodfill C.J.I., Karsch F.J. (1991): Role of the thyroid gland in seasonal reproduction: thyroidectomy blocks seasonal suppression of reproductive neuroendocrine activity in ewes. Endocrinology, 128, 1337-1344.
Go to original source...
Go to PubMed...
- Nicholls T.J., Goldsmith A.R., Dawson A. (1988): Photorefractoriness in birds and comparison with mammals. Physiol. Rev., 68, 133-176.
Go to original source...
Go to PubMed...
- O'Callaghan D., Wendling A., Karsch F.J., Roche J.F. (1993): Effect of exogenous thyroxin on timing of seasonal reproductive transition in ewes. Biol. Reprod., 49, 311-315.
Go to original source...
Go to PubMed...
- Ortega E., Rodriguez E., Ruiz E., Osorio C. (1990): Activity of the hypothalamo-pituitary ovarian axis in hypothyroid rats with or without triiodothyronine replacement. Life Sci., 46, 391-395.
Go to original source...
Go to PubMed...
- Osorio A., Ruiz E., Ortega E. (1998): Possible role of GH/IGF-1 in the ovarian function of adult hypothyroid rats. Mol. Cell. Biochem., 179, 7-11.
Go to original source...
Go to PubMed...
- Pang X.P., Hershman J.M., Mirell C.J., Pakery A.E. (1989): Impairment of hypothalamic-pituitary-thyroid function in rats treated with human recombinant tumor necrosis factor-Th (cachectin). Endocrinology, 125, 76-83.
Go to original source...
Go to PubMed...
- Porter M.B., Cleaver B., Robinson G., Peltier M., Shearer L.C., Dahl G.E., Sharp D.C. (1995): A comparative study examining the role of the thyroid in seasonal reproduction in pony mares and ewes. Biol. Reprod., 52 (S1), Abstract 312.
- Pratt B.R., Wettemann R.P. (1986): The effect of environmental temperature on concentrations of thyroxin and triiodothyronine after thyrotropin releasing hormone in steers. J. Anim. Sci., 62, 1346-1352.
Go to original source...
Go to PubMed...
- Puchala R., Prieto L., Banskalieva V., Goetsch A.L., Lachica M., Sahlu T. (2001): Effects of bovine somatotropin and thyroid hormone status on hormone levels, body weight gain, and mohair fiber growth of Angora goats. J. Anim. Sci., 79, 2913-2919.
Go to original source...
Go to PubMed...
- Reinert B.D. Wilson F.E. (1996): The thyroid and the hypothalamus-pituitary-ovarian axis in American Tree Sparrows (Spizella arborea). Gen. Comp. Endocrinol., 103, 60-70.
Go to original source...
Go to PubMed...
- Richards M.W., Spicer L.J., Wettemann R.P. (1995): Influence of diet and ambient temperature on bovine serum insulin-like growth factor-I and thyroxin: relationships with non-esterified fatty acids, glucose, insulin, luteinizing hormone and progesterone. Anim. Reprod. Sci., 37, 267-279.
Go to original source...
- Riis P.M., Madsen A. (1985): Thyroxin concentrations and secretion rates in relation to pregnancy, lactation and energy balance in goats. J. Endocrinol., 107, 421-427.
Go to original source...
Go to PubMed...
- Robinson J.J., Aitken R.P., Atkinson T., Wallace J.M., McNeilly A.S. (1996): Effects of continuous infusion of thyrotropin-releasing hormone on plasma prolactin and ovarian activity in melatonin-treated ewes. J. Reprod. Fertil., 107, 17-22.
Go to original source...
Go to PubMed...
- Romo G.A., Elsasser T.H., Kahl S., Erdman R.A., Casper D.P. (1997): Dietary fatty acids modulate hormonal responses in lactating cows: mechanistic role for 5'deiodinase activity in tissue. Domest. Anim. Endocrinol., 14, 409-420.
Go to original source...
Go to PubMed...
- Ronge H., Blum J., Clement C., Jans F., Leuenberger H., Binder H. (1988): Somatomedin C in dairy cows related to energy and protein supply and to milk production. Anim. Prod., 47, 165-183
Go to original source...
- Sabour M.P., Lin C.Y. (1996): Association of bovine growth hormone genetic variants with milk production traits in Holstein cattle. Anim. Genet., 27 (Suppl. 2), 105.
Go to PubMed...
- Shi Z.D., Barrell G.K. (1992): Requirement of thyroid function for the expression of seasonal reproductive and related changes in red deer (Cervus elaphus) stags. J. Reprod. Fertil., 94, 251-259.
Go to original source...
Go to PubMed...
- Spicer L.J., Alonso J., Chamberlain C. S. (2001): Effects of thyroid hormones on bovine granulosa and thecal cell function in vitro: dependence on insulin and gonadotropins. J. Dairy Sci., 84, 1069-1076.
Go to original source...
Go to PubMed...
- Stewart R.E., Stevenson J.S., Mee M.O., Rettmer I. (1993): Induction of estrus after thyroidectomy in nonlactating Holstein cows. J. Dairy Sci., 76, 2619- 2623.
Go to original source...
Go to PubMed...
- Svanberg E., Healey J., Mascarenhas D. (2001): Anabolic effects of rhIGF-I/IGFBP-3 in vivo are influenced by thyroid status. Eur. J. Clin. Invest., 31, 329-336.
Go to original source...
Go to PubMed...
- Thrift T.A., Bernal A., Lewis A.W., Neuendorff D.A., Willard C.C., Randel R.D. (1999a): Effects of induced hypothyroidism on weight gains, lactation, and reproductive performance of primiparous Brahman cows. J. Anim. Sci., 77, 1844-1850.
Go to original source...
Go to PubMed...
- Thrift T.A., Bernal A., Lewis, A.W., Neuendorff D.A., Willard C.C., Randel, R.D. (1999b): Effects of induced hypothyroidism or hyperthyroidism on growth and reproductive performance of Brahman heifers. J. Anim. Sci., 77, 1833-1843.
Go to original source...
Go to PubMed...
- Thrun L.A., Dahl G.E., Evans N.P., Karsch F.J. (1996): Time-course of thyroid hormone involvement in the development of anestrus in the ewe. Biol. Reprod., 55, 833-837.
Go to original source...
Go to PubMed...
- Thrun L.A., Dahl G.E., Evans N.P., Karsch F.J. (1997): Effect of thyroidectomy on maintenance of seasonal reproductive suppression in the ewe. Biol. Reprod., 56, 1035-1040.
Go to original source...
Go to PubMed...
- Tiirats T. (1997): Thyroxin, triiodothyronine and reverse-triiodothyronine concentrations in blood plasma
- Wartofsky L., Burman K.D. (1982): Alterations in thyroid function in patients with systemic illnesses: the "euthyroid sick syndrome". Endocr. Rev., 3, 164-217.
Go to original source...
Go to PubMed...
- Webster J.R., Moenter S.M., Woodfill C.J.I., Karsch F.J. in relation to lactational stage, milk yield, energy and (1991a): Role of the thyroid gland in seasonal reprodietary protein intake in Estonian dairy cows. Acta Vet. Scand., 38, 339-348.
- Tohei A., Imai A., Watanabe G., Taya K. (1998): Influence of thiouracil-induced hypothyroidism on adrenal and gonadal functions in adult female rats. J. Vet. Med. Sci., 60, 439-446.
Go to original source...
Go to PubMed...
- Tveit B., Lingaas F., Standal N. (1990): Thyroid function in heifers measured by hormone levels before and after injection of thyrotropin releasing hormone. Effect of parturition Acta Agric. Scand., 40, 183-188.
Go to original source...
- Wakim A.N., Polizotto S.L., Buffo M.J., Marrero M.J., Burholt D.R. (1993): Thyroid hormones in follicular fluid and thyroid hormone receptors in human granulosa cells. Fertil. Steril., 59, 1187-1190.
Go to original source...
Go to PubMed...
- Wakim A.N., Paljug W.R., Jasnosz K.M., Alhakim N., Brown A.B., Burholt D.R. (1994): Thyroid hormone receptor messenger ribonucleic acid in human granulosa duction. II. Thyroxin allows a season-specific suppression of gonadotropin secretion in sheep. Endocrinology, 129, 176-183.
- Webster J.R., Moenter S.M., Barrell G.K., Lehman M.N., Karsch F.J. (1991b): Role of the thyroid gland in seasonal reproduction. III. Thyroidectomy blocks seasonal suppression of gonadotropin-releasing hormone secretion in sheep. Endocrinology, 129, 1635- -1643.
Go to original source...
Go to PubMed...
- Wichtel J.J., Craigie A.L., Freeman D.A., Varela-Alvarez H., Williamson N.B. (1996): Effect of selenium and iodine supplementation on growth rate and on thyroid and somatotropic function in dairy calves at pasture. J. Dairy Sci., 79, 1865-1872.
Go to original source...
Go to PubMed...
- Yambayamba E.S.K., Price M.A., Foxcroft G.R. (1996): Hormonal status, metabolic changes, and resting metabolic rate in beef heifers undergoing compensatory growth. J. Anim. Sci., 74, 57-69.
Go to original source...
Go to PubMed...
- Yoshida T., Monkawa T., Hayashi M., Saruta T. (1997): Regulation of expression of leptin mRNA and secretion of leptin by thyroid hormone in 3T3-L1 adipocytes. Biochem. Biophys. Res. Com., 232, 822-826. and ovarian stromal cells. Fertil. Steril. 62, 531-534. Zanker C.L., Swaine I.L. (1998): The relationship be
Go to original source...
Go to PubMed...
- Wakim A.N., Polizotto S.L., Burholt D.R. (1995a): Influence of thyroxin on human granulosa cell steroidogenesis in vitro. J. Assist. Reprod. Genet., 12, 274-277.
Go to original source...
Go to PubMed...
- Wakim A.N., Polizotto S.L., Burholt D.R. (1995b): Augmentation by thyroxin of human granulosa cells gonadotropin-induced steroidogenesis. Hum. Reprod., 10, 2845-2848.
Go to original source...
Go to PubMed...
- Wallis M., Lioupis A., Wallis O.C. (1998): Duplicate growth hormone genes in sheep and goat. J. Mol. Endocrinol., 21, 1-5. tween serum estradiol concentration and energy balance in young women distance runners. Int. J. Sports Med., 19, 104-108.
Go to original source...
Go to PubMed...
- Zhang Y., Proenca R., Maffei M., Barone M., Leopole L., Friedman J. (1994): Positional cloning of the mouse obese gene and its human homologue. Nature, 372, 425-435.
Go to original source...
Go to PubMed...
- Zhang S.S., Carrillo A.J., Darling D.S. (1997): Expression of multiple thyroid hormone receptor mRNAs in human oocytes, cumulus cells, and granulosa cells. Mol. Hum. Reprod., 3, 555-562.
Go to original source...
Go to PubMed...
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