Vet Med - Czech, 2008, 53(2):111-116 | DOI: 10.17221/1987-VETMED

Lung tuberculosis in a horse caused by Mycobacterium avium subsp. avium of serotype 2: a case report

I. Pavlik1, P. Jahn2, M. Moravkova1, L. Matlova1, F. Treml2, A. Cizek2, E. Nesnalova2, L. Dvorska-Bartosova1, R. Halouzka2
1 Veterinary Research Institute, Brno, Czech Republic
2 University of Veterinary and Pharmaceutical Sciences, Brno, Czech Republic

Interstitial pneumonia (2/3 of the lungs were affected) and diffusely enlarged bronchial and mediastinal lymph nodes were diagnosed by gross examination of a dead 16-year-old mare. Based on histopathological examination and the detection of acid-fast rods after staining by the Ziehl-Neelsen technique, tuberculosis was suspected. Mycobacterium avium subsp. avium of serotype 2 and IS901+/IS1245+ genotype was isolated from the pulmonary lymphnode after five-week incubation at 37°C. Due to the fact that horses have a naturally high resistance to mycobacterial infections, the high age of the mare most likely contributed to the development of the disease.

Keywords: Keywords: avian mycobacteriosis; avian tuberculosis; Mycobacterium avium complex; zoonosis

Published: February 29, 2008  Show citation

ACS AIP APA ASA Harvard Chicago Chicago Notes IEEE ISO690 MLA NLM Turabian Vancouver
Pavlik I, Jahn P, Moravkova M, Matlova L, Treml F, Cizek A, et al.. Lung tuberculosis in a horse caused by Mycobacterium avium subsp. avium of serotype 2: a case report. Vet Med - Czech. 2008;53(2):111-116. doi: 10.17221/1987-VETMED.
Share...
Download citation
  • BibTeX (.bib)
  • Bookends (.ris)
  • EasyBib (.ris)
  • EndNote (.enw)
  • EndNote 8 (.xml)
  • ISI WoS (.isi)
  • Medlars (.medlars)
  • Mendeley (.ris)
  • MODS (.xml)
  • Papers (.ris)
  • RefWorks (.txt)
  • RefManager (.ris)
  • RIS (.ris)
  • MS Word (.xml)
  • Zotero (.ris)
    • Open full article

    References

    1. Bartos M., Hlozek P., Svastova P., Dvorska L., Bull T., Matlova L., Parmova I., Kuhn I., Stubbs J., Moravkova M., Kintr J., Beran V., Melicharek I., Ocepek M., Pavlik I. (2006): Identification of members of Mycobacterium avium species by Accu-Probes, serotyping, and single IS900, IS901, IS1245 and IS901-flanking region PCR with internal standards. Journal of Microbiological Methods, 64, 333-345. Go to original source... Go to PubMed...
    2. Brown J.A., Hartus S., White P.C. (1994): Persistence of Mycobacterium bovis in cattle. Trends in Microbiology, 2, 43-46. Go to original source... Go to PubMed...
    3. Dvorska L., Parmova I., Lavickova M., Bartl J., Vrbas V., Pavlik I. (1999): Isolation of Rhodococcus equi and atypical mycobacteria from lymph nodes of pigs and cattle in herds with the occurrence of tuberculoid gross changes in the Czech Republic over the period 1996-1998. Veterinarni Medicina, 44, 321-330.
    4. Dvorska L., Bartos M., Ostadal O., Kaustova J., Matlova L., Pavlik I. (2002): IS1311 and IS1245 restriction fragment length polymorphism analyses, serotypes, and drug susceptibilities of Mycobacterium avium complex isolates obtained from a human immunodeficiency virus-negative patient. Journal of Clinical Microbiology, 40, 3712-3719. Go to original source... Go to PubMed...
    5. Dvorska L., Bull T.J., Bartos M., Matlova L., Svastova P., Weston R.T., Kintr J., Parmova I., van Soolingen D., Pavlik I. (2003): A standardised restriction fragment length polymorphism (RFLP) method for typing Mycobacterium avium isolates links IS901 with virulence for birds. Journal of Microbiological Methods, 55, 11-27. Go to original source... Go to PubMed...
    6. Dvorska L., Matlova L., Ayele W.Y., Fischer O.A., Amemori T., Weston R.T., Alvarez J., Beran V., Moravkova M., Pavlik I. (2007): Avian tuberculosis in naturally infected captive water birds of the Ardeidae and Threskiornithidae families studied by serotyping, IS901 RFLP typing and virulence for poultry. Veterinary Microbiology, 119, 366-374. Go to original source... Go to PubMed...
    7. Konyha L.D., Kreier J.P. (1971): The significance of tuberculin tests in the horse. American Review of Respiratory Diseases, 103, 91-99.
    8. Lofstedt J., Jakowski R.M. (1989): Diagnosis of avian tuberculosis in a horse by use of liver-biopsy. Journal of the American Veterinary Medical Association, 194, 260-262. Go to PubMed...
    9. Luke D. (1958): Tuberculosis in the horse, pig, sheep and goat. Veterinary Record, 70, 529-536.
    10. Mair T.S., Jenkins P.A. (1990): Isolation of mycobacteria from nasal cavity of horses. Equine Veterinary Journal, 22, 54-55. Go to original source... Go to PubMed...
    11. Mair T.S., Taylor F.G.R., Gibbs C., Lucke V.M. (1986): Generalised avian tuberculosis in a horse. Equine Veterinary Journal, 18, 226-230. Go to original source... Go to PubMed...
    12. Matlova L., Dvorska L., Bartl J., Bartos J., Ayele W.Y., Alexa M., Pavlik I. (2003): Mycobacteria isolated from the environment of pig farms in the Czech Republic during the years 1996 to 2002. Veterinarni Medicina, 48, 343- 357. http://www.vri.cz/docs/vetmed/48-12-343.pdf Go to original source...
    13. Matlova L., Dvorska L., Palecek K., Maurenc L., Bartos M., Pavlik I. (2004): Impact of sawdust and wood shavings in bedding on pig tuberculous lesions in lymph nodes, and IS1245 RFLP analysis of Mycobacterium avium subsp. hominissuis of serotypes 6 and 8 isolated from pigs and environment. Veterinary Microbiology, 102, 227-236. Go to original source... Go to PubMed...
    14. Merrit A.M., Merkal R.S., Skye D., Selway S. (1975): A case of avian tuberculosis of the intestinal tract of a horse. Digestive Diseases, 20, 598. Go to original source...
    15. Monreal L., Segura D., Segales J., Garrido J.M., Prades M. (2001): Diagnosis of Mycobacterium bovis infection in a mare. Veterinary Record, 149, 712-714. Go to original source...
    16. Moravkova M., Bartos M., Dvorska-Bartosova L., Beran V., Parmova I., Ocepek M., Pate M., Pavlik I. (2007): Genetic variability of Mycobacterium avium subsp. avium of pig isolates. Veterinarni Medicina, 52, 430- 436. http://www.vri.cz/docs/vetmed/52-10-430.pdf Go to original source...
    17. Muser R., Nassal J. (1962): Tuberculosis, tuberculin tests and mycobacteria in horses (in Germany). Rindertuberkulose und Brucellose 11, 118-126.
    18. Pate M., Zdovc I., Pirs T., Krt B., Ocepek M. (2004): Isolation and characterisation of Mycobacterium avium and Rhodococcus equi from granulomatous lesions of swine lymph nodes in Slovenia. Acta Veterinaria Hungarica, 52, 143-150. Go to original source... Go to PubMed...
    19. Pavlik I. (2006): The experience of new European Union Member States concerning the control of bovine tuberculosis. Veterinary Microbiology, 112, 221-230. Go to original source... Go to PubMed...
    20. Pavlik I., Svastova P., Bartl J., Dvorska L., Rychlik I. (2000): Relationship between IS901 in the Mycobacterium avium complex strains isolated from birds, animals, humans and environment and virulence for poultry. Clinical and Diagnostic Laboratory Immunology, 7, 212-217. Go to original source... Go to PubMed...
    21. Pavlik I., Jahn P., Dvorska L., Bartos M., Novotny L., Halouzka R. (2004): Mycobacterial infections in horses: a review of the literature. Veterinarni Medicina, 49, 427-440. http://www.vri.cz/docs/vetmed/49-11-427.pdf Go to original source...
    22. Pavlik I., Matlova L., Dvorska L., Shitaye J.E., Parmova I. (2005): Mycobacterial infections in cattle and pigs caused by Mycobacterium avium complex members and atypical mycobacteria in the Czech Republic during 2000-2004. Veterinarni Medicina, 50, 281-290. Go to original source...
    23. Pearson E.G., Heidel J.R. (1998): Colonic and rectal biopsy as a diagnostic aid in horses. Compendium on Continuing Education for the Practicing Veterinarian, 20, 1354-1359.
    24. Reed C., Von Reyn C.F., Chamblee S., Ellerbrock T.V., Johnson J.W., Marsh B.J., Johnson L.S., Trenschel R.J., Horsburgh C.R. (2006): Environmental risk factors for infection with Mycobacterium avium complex. American Journal of Epidemiology, 164, 32-40. Go to original source... Go to PubMed...
    25. Shitaye J.E., Matlova L., Horvathova A., Moravkova M., Dvorska-Bartosova L., Treml F., Lamka J., Pavlik I. (2007): Mycobacterium avium subsp. avium distribution studied in a naturally infected hen flock and in the environment by culture, serotyping and IS901 RFLP methods. Veterinary Microbiology, 127, 155-164. Go to original source... Go to PubMed...
    26. Skalka B. (1987): Dynamics of equi-factor antibodies in sera of foals kept on farms with differing histories of Rhodococcus equi pneumonia. Veterinary Microbiology, 14, 269-276. Go to original source... Go to PubMed...
    27. Sussland Z., Hrdinova V. (1976): Use of rapid agglutination in the serotyping of the Mycobacterium aviumintracellulare complex (in Czech). Veterinarni Medicina (Praha), 21, 209-213.
    28. Trcka I., Lamka J., Suchy R., Kopecna M., Beran V., Moravkova M., Horvathova A., Bartos M., Parmova I., Pavlik I. (2006): Mycobacterial infections in European wild boars (Sus scrofa) in the Czech Republic during the years 2002 to 2005. Veterinarni Medicina, 51, 320-332. http://www.vri.cz/docs/vetmed/51-5320.pdf Go to original source...
    29. Vacek Z. (1972): Histology and Histological Methods (in Czech). 3rd ed. Avicenum, Prague, 320 pp.
    30. Wilton S., Cousins D. (1992): Detection and identification of multiple mycobacterial pathogens by DNA amplification in a single tube. PCR Methods and Applications, 1, 269-273. Go to original source... Go to PubMed...

    This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International (CC BY NC 4.0), which permits non-comercial use, distribution, and reproduction in any medium, provided the original publication is properly cited. No use, distribution or reproduction is permitted which does not comply with these terms.


    Return to the content