Vet Med - Czech, 2008, 53(9):469-500 | DOI: 10.17221/1979-VETMED

Nitrofuran antibiotics: a review on the application, prohibition and residual analysis

M. Vass*, K. Hruska, M. Franek
Veterinary Research Institute, Brno, Czech Republic

Nitrofuran antibiotics, employed for the treatment of bacterial diseases in livestock production, were banned from use in the European Union (EU) in 1995 due to concerns about the carcinogenicity of their residues in edible tissue. This review provides an overview of nitrofuran toxicity, metabolism, and also specific aspects of legislation surrounding their prohibition. Special attention is devoted to semicarbazide - a nitrofuran metabolite and food contaminant. Analytical procedures for nitrofuran analysis in various matrices and validation requirements for screening and confirmation methods with respect to EU regulations are also reviewed.

Keywords: nitrofurans; tissue bound metabolites; semicarbazide; bioavailability; mutagenicity; legislation; sample preparation; validation; detection methods

Published: September 30, 2008  Show citation

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Vass M, Hruska K, Franek M. Nitrofuran antibiotics: a review on the application, prohibition and residual analysis. Vet Med - Czech. 2008;53(9):469-500. doi: 10.17221/1979-VETMED.
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    References

    1. Ahmed H.H., Ei-Aziem S.H.A., Abdel-Wahhab M.A. (2008): Potential role of cysteine and methionine in the protection against hormonal imbalance and mutagenicity induced by furazolidone in female rats. Toxicology, 243, 31-42. Go to original source... Go to PubMed...
    2. Angelini N.M., Rampini O.D., Mugica H. (1997): Liquid chromatographic determination of nitrofuran residues in bovine muscle tissues. Journal of AOAC International, 80, 481-485. Go to original source... Go to PubMed...
    3. Anon (2008): FoodBRAND and the nitrofuran crisis in global food production. Agri-Food and Biosciences Institute web site http://www.afbini.gov.uk/index/services/diagnostic/services-diagnostic-analyticalservices/foodbrand-introduction/foodbrand-the-nitrofuran-crisis.htm
    4. Balizs G., Hewitt A. (2003): Determination of veterinary drug residues by liquid chromatography and tandem mass spectrometry. Analytica Chimica Acta, 492, 105-131. Go to original source...
    5. Barbosa J., Moura S., Barbosa R., Ramos F., da Silveira M.I.N. (2007): Determination of nitrofurans in animal feeds by liquid chromatography-UV photodiode array detection and liquid chromatography-ionspray tandem mass spectrometry. Analytica Chimica Acta, 586, 359-365. Go to original source... Go to PubMed...
    6. Becalski A., Lau B.P.Y., Lewis D., Seaman S.W. (2004): Semicarbazide formation in azodicarbonamide-treated flour: A model study. Journal of Agricultural and Food Chemistry, 52, 5730-5734. Go to original source... Go to PubMed...
    7. Becalski A., Lau B.P.Y., Lewis D., Seaman S. (2006): Semicarbazide in Canadian bakery products. Food Additives and Contaminants, 23, 107-109. Go to original source... Go to PubMed...
    8. Bock C., Gowik P., Stachel C. (2007a): Matrix-comprehensive in-house validation and robustness check of a confirmatory method for the determination of four nitrofuran metabolites in poultry muscle and shrimp by LC-MS/MS 1. Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences, 856, 178-189. Go to original source... Go to PubMed...
    9. Bock C., Stachel C., Gowik P. (2007b): Validation of a confirmatory method for the determination of residues of four nitrofurans in egg by liquid chromatography-tandem mass spectrometry with the software InterVal. Analytica Chimica Acta, 586, 348-358. Go to original source... Go to PubMed...
    10. Botsoglou N.A. (1988): Determination of furazolidone in eggs by high-performance liquid-chromatography. 1224-1227. Go to original source...
    11. Bryant D.W., Mccalla D.R. (1980): Nitrofuran induced mutagenesis and error prone repair in EscherichiaColi. Chemico-Biological Interactions, 31, 151-166. Go to original source... Go to PubMed...
    12. Cabrita A.M.S., Farinha R., Ramos A., Silva F.C.E., Patricio J.A.B. (2007): Effects of semicarbazide exposure on endocrine pancreas morphology. Toxicology Letters, 172, 201. Go to original source...
    13. Chang C., Peng D.P., Wu J.E., Wang Y.L., Yuan Z.H. (2008): Development of an indirect competitive ELISA for the detection of furazolidone marker residue in animal edible tissues. Journal of Agricultural and Food Chemistry, 56, 1525-1531. Go to original source... Go to PubMed...
    14. Chu P.S., Lopez M.I. (2005): Liquid chromatographytandem mass spectrometry for the determination of protein-bound residues in shrimp dosed with nitrofurans. Journal of Agricultural and Food Chemistry, 53, 8934-8939. Go to original source... Go to PubMed...
    15. Commission Decision (2002): Commission Decision 2002/657/EC of 12 August 2002 implementing Council directive 96/23/EC concerning the performance of analytical methods and the interpretation of results. Official Journal of the European Communities, L221, 8-36. http://faolex.fao.org/docs/pdf/eur49615.pdf
    16. Commission Decision (2003): Commission Decision 2003/181/EC of 13 March 2003 amending Decision 2002/657/EC as regards the setting of minimum required performance limits (MRPLs) for certain residues in food of animal origin. Official Journal of the European Communities, L71, 17-18. http://eur-lex.europa.eu/pri/en/oj/dat/2003/l_071/l_07120030315en00170018.pdf
    17. Commission Directive (2004): Commission Directive 2004/1/EC of 6 January 2004 amending Directive 2002/72/EC as regards the suspension of the use of azodicarbonamide as blowing agent. Official Journal of the European Communities, L7, 45-46. http://eurlex.europa.eu/LexUriServ/LexUriServ.do?uri=OJ:L:2004:007:0045:0046:EN:PDF
    18. Commission Regulation (1995): Commission Regulation (EC) 1442/95 of 26 June 1995 amending Annexes I, II, III and IV of Regulation (ECC) No 2377/90 laying down a Community Procedure for the establishment of maximum residue limits of veterinary medicinal products in foodstuffs of animal origin. Official Journal of the European Communities, L143, 26-30. http://eur-lex.europa.eu/smartapi/cgi/sga_doc?smartapi!celexapi!prod!CELEXnumdoc#doc=31995R1442&model=guichett=en
    19. Commission Regulation (2002): Commission Regulation (EC) 178/2002 of 28 January 2002 laying down the general principles and requirements of food law, establishing the European Food Safety Authority and laying down procedures in matters of food safety. Official Journal of the European Communities, L31, 1-24. http://eur-lex.europa.eu/pri/en/oj/dat/2002/l_031/l_03120020201en00010024.pdf
    20. Conneely A., Nugent A., O'Keeffe M. (2002): Use of solid phase extraction for the isolation and clean-up of a derivatised furazolidone metabolite from animal tissues. Analyst, 127, 705-709. Go to original source... Go to PubMed...
    21. Conneely A., Nugent A., O'Keeffe M., Mulder P.P.J., van Rhijn J.A., Kovacsics L., Fodor A., McCracken R.J., Kennedy D.G. (2003): Isolation of bound residues of nitrofuran drugs from tissue by solid-phase extraction with determination by liquid chromatography with UV and tandem mass spectrometric detection. Analytica Chimica Acta, 483, 91-98. Go to original source...
    22. Cooper K.M., Kennedy D.G. (2005): Nitrofuran antibiotic metabolites detected at parts per million concentrations in retina of pigs - a new matrix for enhanced monitoring of nitrofuran abuse. Analyst, 130, 466- 468. Go to original source... Go to PubMed...
    23. Cooper K.M., Kennedy D.G. (2007): Stability studies of the metabolites of nitrofuran antibiotics during storage and cooking. Food Additives and Contaminants, 24, 935-942. Go to original source... Go to PubMed...
    24. Cooper K.M., Caddell A., Elliott C.T., Kennedy D.G. (2004a): Production and characterisation of polyclonal antibodies to a derivative of 3-amino-2-oxazolidinone, a metabolite of the nitrofuran furazolidone. Analytica Chimica Acta, 520, 79-86. Go to original source...
    25. Cooper K.M., Elliott C.T., Kennedy D.G. (2004b): Detection of 3-amino-2-oxazolidinone (AOZ), a tissuebound metabolite of the nitrofuran furazolidone, in prawn tissue by enzyme immunoassay. Food Additives and Contaminants, 21, 841-848. Go to original source... Go to PubMed...
    26. Cooper K.M., McCracken R.J., Kennedy D.G. (2005a): Nitrofurazone accumulates in avian eyes - a replacement for semicarbazide as a marker of abuse. Analyst, 130, 824-827. Go to original source... Go to PubMed...
    27. Cooper K.M., Mulder P.P., van Rhijn J.A., Kovacsics L., McCracken R.J., Young P.B., Kennedy D.G. (2005b): Depletion of four nitrofuran antibiotics and their tissue-bound metabolites in porcine tissues and determination using LC-MS/MS and HPLC-UV. Food Additives and Contaminants, 406-414. Go to original source...
    28. Cooper K.M., Samsonova J.V., Plumpton L., Elliott C.T., Kennedy D.G. (2007): Enzyme immunoassay for semicarbazide - the nitrofuran metabolite and food contaminant. Analytica Chimica Acta, 592, 64-71. Go to original source... Go to PubMed...
    29. Cooper K.M., McCracken R.J., Buurman M., Kennedy D.G. (2008): Residues of nitrofuran antibiotic parent compounds and metabolites in eyes of broiler chickens. Food Additives and Contaminants, 25, 548-556. Go to original source... Go to PubMed...
    30. Council Directive (2008): Council Directive 96/23/EU of 29 April 1996, on measures to monitor certain substances and residues there of in live animals and animal products and repeating Directives 85/358/EEC and Decisins 89/187/EEC and 91/664/EEC. Official Journal of the European Communities No. L 125, 10-32. Amended by (EC) No 806/2003 (Official Journal of the European Communities No. L 122, 16.05.2003, 1) amended by ACT of 2004 http://www.wetgiw.gov.pl/old/UE/prawo/96_23/e9623rl.pdf
    31. De Angelis I., Rossi L., Pedersen J.Z., Vignoli A.L., Vincentini O., Hoogenboom L.A.P., Polman T.H.G., Stammati A., Zucco F. (1999): Metabolism of furazolidone: alternative pathways and modes of toxicity in different cell lines. Xenobiotica, 29, 1157-1169. Go to original source... Go to PubMed...
    32. de la Calle M.B., Anklam E. (2005): Semicarbazide: occurrence in food products and state-of-the-art in analytical methods used for its determination. Analytical and Bioanalytical Chemistry, 382, 968-977. Go to original source... Go to PubMed...
    33. de la Calle M.B., Szilagyi S. (2006): Determination od semicarbizide in fresh egg and whole egg powder by liquid chromatography/tandem mass spectrometry: Interlaboratory validaiton study. Veterinary Drug Residues, 89, 1664-1671. Go to original source...
    34. De la Fuente M. (1986): Teratogenic effect of semicarbazide in Wister rats. Biology of the Neonate, 49, 150-157. Go to original source... Go to PubMed...
    35. De la Fuente M., Hernanz A., Alia M. (1983): Effect of semicarbazide on the perinatal development of the rat: changes in DNA, RNA and protein content. Experimental Clinical Pharmacology, 5, 287-297.
    36. De Souza S.V.C., Junqueira R.G., Ginn R. (2005): Analysis of semicarbazide in baby food by liquid chromatography tandem mass spectrometry (LC-MS-MS) - In-house method validation. Journal of Chromatography A, 1077, 151-158. Go to original source... Go to PubMed...
    37. Diaz T.G., Cabanillas A.G., Valenzuela M.I.A., Correa C.A., Salinas F. (1997): Determination of nitrofurantoin, furazolidone and furaltadone in milk by high-performance liquid chromatography with electrochemical detection. Journal of Chromatography A, 764, 243-248. Go to original source... Go to PubMed...
    38. Diblikova I., Cooper K.M., Kennedy D.G., Franek M. (2005): Monoclonal antibody-based ELISA for the quantification of nitrofuran metabolite 3-amino-2oxazolidinone in tissues using a simplified sample preparation. Analytica Chimica Acta, 540, 285-292. Go to original source...
    39. Draisci R., Giannetti L., Lucentini L., Palleschi L., Brambilla G., Serpe L., Gallo P. (1997): Determination of nitrofuran residues in avian eggs by liquid chromatography UV photodiode array detection and confirmation by liquid chromatography ionspray mass spectrometry. Journal of Chromatography A, 777, 201-211. Go to original source...
    40. European Commission (2003): Opinion of the Scientific Committee on Food on the 23rd additional list of monomers and additives for food contact materials. http://ec.europa.eu/food/fs/sc/scf/out181_en.pdf
    41. European Commission (2008): Rapid Alert System for Food and Feed. http://ec.europa.eu/food/food/rapidalert/index_en.htm
    42. European Food Safety Authority (2005): Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food on a request from the Commission related to Semicarbazide in Food. The EFSA Journal, 219, 1-36. http://www.efsa.eu.int/EFSA/Scientific_Opinion/afc_summ_ej219_semicarbazide_en1.pdf?ssbinary=true Go to original source...
    43. Finzi J.K., Donato J.L., Sucupira M., De Nucci G., McCracken R.J., van Rhijn J.A., Kennedy D.G. (2005): Determination of nitrofuran metabolites in poultry muscle and eggs by liquid chromatography-tandem mass spectrometry. Journal Chromatography B Analytical Technology of Biomedical Life Sciences, 824, 30-35. Go to original source... Go to PubMed...
    44. Franek M., Diblikova I., Vass M., Kotkova L., Stastny K., Frgalova K., Hruska K. (2006): Validation of a monoclonal antibody-based ELISA for the quantification of the furazolidone metabolite (AOZ) in eggs using various sample preparation. Veterinarni Medicina, 51, 248-257. Go to original source...
    45. Gao A., Chen Q., Cheng Y., Lei J., Zeng L. (2007): Preparation of monoclonal antibodies against a derivative of semicarbazide as a metabolic target of nitrofurazone. Analytica Chimica Acta, 592, 58-63. Go to original source...
    46. George J.D., Fail P.A., Grizzle T.B., Heindel J.J. (1996): Nitrofurazone: Reproductive assessment by continuous breeding in Swiss mice. Fundamental and Applied Toxicology, 34, 56-66. Go to original source... Go to PubMed...
    47. Ginn R., Wilson L., De Souza S.V.C., de la Calle M.B., Barbosa J., Berendsen B., Bockborn I., Brandtner M., Delahaut P., Doering T., Fuerst P., Griffin C., Gude T., Janosi A., Jaus A., Kennedy G., Mandix M., Hilla E.M., Plonevez S., Posyniak A., Saari L., van Bruijnsvoort M., Verdon E., Wohlfarth R. (2006): Determination of semicarbazide in baby food by liquid chromatography/ tandem mass spectrometry: Interlaboratory validation study. Journal of AOAC International, 89, 728-734. Go to original source... Go to PubMed...
    48. Gottschall D.W., Wang R. (1995): Depletion and Bioavailability of [C-14] Furazolidone Residues in Swine Tissues. Journal of Agricultural and Food Chemistry, 43, 2520-2525. Go to original source...
    49. Guay D.R. (2008): Contempory management of uncomplicated urinary tract infections. Drugs, 68, 1169-1205. Go to original source... Go to PubMed...
    50. Hoenicke K., Gatermann R. (2006): How can zero tolerances be controlled? The case study of Nitrofurans. Accreditation and Quality Assurance, 11, 29-32. Go to original source...
    51. Hoenicke K., Gatermann R., Hartig L., Mandix M., Otte S. (2004): Formation of semicarbazide (SEM) in food by hypochlorite treatment: is SEM a specific marker for nitrofurazone abuse? Food Additives and Contaminants, 21, 526-537. Go to original source... Go to PubMed...
    52. Hoogenboom L.A.P., Tomassini O., Oorsprong M.B., Kuiper H.A. (1991): Use of pig hepatocytes to study the inhibition of monoamine oxidase by furazolidone. Food and Chemical Toxicology, 29, 185-191. Go to original source... Go to PubMed...
    53. Hoogenboom L.A.P., Berghmans M.C.J., Polman T.H.G., Parker R., Shaw I.C. (1992): Depletion of proteinbound furazolidone metabolites containing the 3-amino-2-oxazolidinone side-chain from liver, kidney and muscle tissues from pigs. Food Additives and Contaminants, 9, 623-630. Go to original source... Go to PubMed...
    54. Hoogenboom L.A.P., van Bruchem G.D., Sonne K., Enninga I.C., van Rhijn J.A., Heskamp H., HuveneersOorsprong M.B.M., van der Hoeven J.C.M., Kuiper H.A. (2002): Absorption of a mutagenic metabolite released from protein-bound residues of furazolidone. Environmental Toxicology and Pharmacology, 11, 273-287. Go to original source... Go to PubMed...
    55. Horne E., Cadogan A., OKeeffe M., Hoogenboom L.A.P. (1996): Analysis of protein-bound metabolites of furazolidone and furaltadone in pig liver by high-performance liquid chromatography and liquid chromatography mass spectrometry. Analyst, 121, 1463-1468. Go to original source... Go to PubMed...
    56. Hu X.Z., Xu Y., Yediler A. (2007): Determinations of residual furazolidone and its metabolite, 3-amino-2oxazolidinone (AOZ), in fish feeds by HPLC-UV and LC-MS/MS, respectively. Journal of Agricultural and Food Chemistry, 55, 1144-1149. Go to original source... Go to PubMed...
    57. Kari R. (1988): NTP technical report on the toxicology and carcinogenesis studies of NFZ in F344/N rats and B6C3F1 mice (feed studies). U.S.Department of Health and Human Services, 1-186.
    58. Kennedy G. (2004): Analytical methods for nitrofurans: Lessons to be learned and new developments. In: Joint FAO/WHO Technical Workshop on Residues of Veterinary Drugs without ADI/MRL, Bangkok, Thailand, 87-91. http://www.fao.org/docrep/008/y5723e/y5723e0n.htm#bm23
    59. Khong S.P., Gremaud E., Richoz J., Delatour T., Guy P.A., Stadler R.H., Mottier P. (2004): Analysis of matrixbound nitrofuran residues in worldwide-originated honeys by isotope dilution high-performance liquid chromatography-tandem mass spectrometry. Journal of Agricultural and Food Chemistry, 52, 5309-5315. Go to original source... Go to PubMed...
    60. Kumar L., Toothill J.R., Ho K.B. (1994): Determination of nitrofuran residues in poultry muscle tissues and eggs by liquid-chromatography. Journal of AOAC International, 77, 591-595. Go to original source... Go to PubMed...
    61. Leitner A., Zollner P., Lindner W. (2001): Determination of the metabolites of nitrofuran antibiotics in animal tissue by high-performance liquid chromatographytandem mass spectrometry. Journal of Chromatography A, 939, 49-58. Go to original source... Go to PubMed...
    62. Lui W., Zhao C., Zhang Y., Lu S., Liu J., Xi R. (2007): Preparation of polyclonal antibodies to a derivative of 1-aminohydantoin (AHD) and development of an indirect competitive ELISA for the detection of nitrofurantoin residue in water. Journal of Agriculture and Food Chemistry, 55, 6829-6834. Go to original source... Go to PubMed...
    63. Mccalla D.R. (1983): Mutagenicity of nitrofuran derivatives - Review. Environmental Mutagenesis, 5, 745-765. Go to original source... Go to PubMed...
    64. Mccalla D.R., Kaiser C., Reuvers A. (1971): Breakage of bacterial DNA by nitrofuran derivatives. Cancer Research, 31, 2184-2188.
    65. McCracken R.J., Kennedy D.G. (1997a): Determination of the furazolidone metabolite, 3-amino-2-oxazolidinone, in porcine tissues using liquid chromatographythermospray mass spectrometry and the occurrence of residues in pigs produced in Northern Ireland. Journal of Chromatography B, 691, 87-94. Go to original source... Go to PubMed...
    66. McCracken R.J., Kennedy D.G. (1997b): The bioavailability of residues of the furazolidone metabolite 3-amino2-oxazolidinone in porcine tissues and the effect of cooking upon residue concentrations. Food Additives and Contaminants, 14, 507-513. Go to original source... Go to PubMed...
    67. McCracken R.J., Kennedy D.G. (2007): Detection, accumulation and distribution of nitrofuran residues in egg yolk, albumen and shell. Food Additives and Contaminants, 24, 26-33. Go to original source... Go to PubMed...
    68. McCracken R.J., Blanchflower W.J., Rowan C., Mccoy M.A., Kennedy D.G. (1995): Determination of furazolidone in porcine tissue using thermospray liquid chromatography-mass spectrometry and a study of the pharmacokinetics and stability of its residues. Analyst, 120, 2347-2351. Go to original source... Go to PubMed...
    69. McCracken R.J., Spence D.E., Floyd S.D., Kennedy D.G. (2001): Evaluation of the residues of furazolidone and its metabolite, 3-amino-2-oxazolidinone (AOZ), in eggs. Food Additives and Contaminants, 18, 954- 959. Go to original source... Go to PubMed...
    70. McCracken R.J., van Rhijn J.A., Kennedy D.G. (2005a): Transfer of nitrofuran residues from parent broiler breeder chickens to broiler progeny. British Poultry Science, 46, 287-292. Go to original source... Go to PubMed...
    71. McCracken R.J., van Rhijn J.A., Kennedy D.G. (2005b): The occurrence of nitrofuran metabolites in the tissues of chickens exposed to very low dietary concentrations of the nitrofurans. Food Additives and Contaminants, 22, 567-572. Go to original source... Go to PubMed...
    72. Mori K., Yasuno A., Matsumoto K. (1960): Induction of pulmonary tumours in mice with isonicotinic acid hydrazid. Gann, 51, 83-89. Go to PubMed...
    73. Mottier P., Khong S.P., Gremaud E., Richoz J., Delatour T., Goldmann T., Guy P.A. (2005): Quantitative determination of four nitrofuran metabolites in meat by isotope dilution liquid chromatography-electrospray ionisation-tandem mass spectrometry. Journal of Chromatography A, 1067, 85-91. Go to original source... Go to PubMed...
    74. Mulder P.P.J., Beumer B., van Rhijn J.A. (2007): The determination of biurea: A novel method to discriminate between nitrofurazone and azodicarbonamide use in food products. Analytica Chimica Acta, 586, 366-373. Go to original source... Go to PubMed...
    75. Nouws J.F.M., Laurensen J. (1990): Postmortal degradation of furazolidone and furaltadone in edible tissues of calves. Veterinary Quarterly, 12, 56-59. Go to original source... Go to PubMed...
    76. O'Keeffe M., Conneely A., Cooper K.M., Kennedy D.G., Kovacsics L., Fodor A., Mulder P.P.J., van Rhijn J.A., Trigueros G. (2004): Nitrofuran antibiotic residues in pork the FoodBRAND retail survey. Analytica Chimica Acta, 520, 125-131. Go to original source...
    77. Pereira A.S., Donato J.L., De Nucci G. (2004): Implications of the use of semicarbazide as a metabolic target of nitrofurazone contamination in coated products. Food Additives and Contaminants, 21, 63-69. Go to original source... Go to PubMed...
    78. Petri W. (2005): Treatment of giardiasis. Current Treatment Options in Gastroenterology, 8, 13-17. Go to original source... Go to PubMed...
    79. Rodziewicz L. (2008): Determination of nitrofuran metabolites in milk by liquid chromatography-electrospray ionisation tandem mass spectrometry. Journal of Chromatography B, 867, 156-160. Go to original source... Go to PubMed...
    80. Rodziewicz L., Zawadzka I. (2007): Determination of nitrofuran metabolite residues in animal tissues by LC-MS/MS method. Roczniki Panstwowego Zakladu Higieny, 58, 625-632. Go to PubMed...
    81. Roychowdhury A., Pan A., Dutta D., Mukhopadhyay A.K., Ramamurthy T., Nandy R.K., Bhattacharya S.K., Bhattacharya M.K. (2008): Emergence of tetracyclineresistant Vibrio cholerae O1 serotype Inaba, in Kolkata, India. Japanese Journal of Infectious Diseases, 61, 128-129. Go to original source...
    82. Saari L., Peltonen K. (2004): Novel source of semicarbazide: levels of semicarbazide in cooked crayfish samples determined by LC/MS/MS. Food Additives and Contaminants, 21, 825-832. Go to original source... Go to PubMed...
    83. Samsonova J.V., Douglas A.J., Cooper K.M., Kennedy D.G., Elliot C.T. (2008): The identification of potential alternative biomarkers of nitrofurazone abuse in animal derived food products. Food and Chemical Toxicology, 46, 1548-1554. Go to original source... Go to PubMed...
    84. Stadler R.H., Mottier P., Guy P., Gremaud E., Varga N., Lalljie S., Whitaker R., Kintscher J., Dudler V., Read W.A., Castle L. (2004): Semicarbazide is a minor thermal decomposition product of azodicarbonamide used in the gaskets of certain food jars. Analyst, 129, 276-281. Go to original source... Go to PubMed...
    85. Steffeck A.J., Verrusio C., Watkins C.A. (1972): Cleft plate in rodents after maternal treatment with various lathyrogenic agents. Tetratology, 5, 33-40. Go to original source... Go to PubMed...
    86. Szilagyi S., de la Calle B. (2006): Development and validation of an analytical method for the determination of semicarbazide in fresh egg and in egg powder based on the use of liquid chromatography tandem mass spectrometry. Analytica Chimica Acta, 572, 113-120. Go to original source... Go to PubMed...
    87. Toth B., Shimizu H., Erickson J. (1975): Carbamylhydrazine hydrochloride as a lung and blood-vessel tumor inducer in Swiss mice. European Journal of Cancer, 11, 17-22. Go to original source... Go to PubMed...
    88. Ulland B., Weisburg E.K., Weisburg J.H. (1973): Chronic toxicity and carcinogenicity of industrial chemicals and pesticides. Toxicology and Applied Pharmacology, 25, 446.
    89. US Environmental Protection Agency (2008): Chemicals known to the state that cause cancer or reproductive toxicity. Office of Environmental Health Hazard Assessment, USA, 1-18.
    90. Van Koten-Vermeulen J.E.M. (1993): Report of the 40th Meeting of the Joint FAO/WHO Expert Committee On Food Additives (JECFA), World Health Organisation, Geneva. 85.
    91. Vasheghani M.M., Bayat M., Rezaei F., Bayat A., Karimipour M. (2008): Effect of low-level laser therapy on mast cells in second-degree burns in rats. Photomedicine and Laser Surgery, 26, 1-5. Go to original source... Go to PubMed...
    92. Vass M., Kotkova L., Diblikova I., Nevorankova Z., Cooper K.M., Kennedy D.G., Franek M. (2005): Production and characterisation of monoclonal antibodies for the detection of AOZ, a tissue bound metabolite of furazolidone. Veterinarni Medicina, 50, 300-310. Go to original source...
    93. Vass M., Diblikova I., Franek M. (2008a): ELISA for semicarbazide and its application for screening in food contamination. Analytica Chimica Acta, 608, 86-94. Go to original source... Go to PubMed...
    94. Vass M., Diblikova I., Kok E., Stastny K., Frgalova K., Hruska K., Franek M. (2008b): In-house validation of an ELISA method for screening of semicarbazide in eggs. Food Additives and Contaminants Part A - Chemistry Analysis Control Exposure & Risk Assessment, 25, 930-936. Go to original source... Go to PubMed...
    95. Verdon E., Couedor P., Sanders P. (2007): Multi-residue monitoring for the simultaneous determination of five nitrofurans (furazolidone, furaltadone, nitrofurazone, nitrofurantoine, nifursol) in poultry muscle tissue through the detection of their five major metabolites (AOZ, AMOZ, SEM, AHD, DNSAH) by liquid chromatography coupled to electrospray tandem mass spectrometry - In-house validation in line with Commission Decision 657/2002/EC. Analytica Chimica Acta, 586, 336-347. Go to original source... Go to PubMed...
    96. Vroomen L.H.M., Berghmans M.C.J., Vanleeuwen P., Vanderstruijs T.D.B., Devries P.H.U., Kuiper H.A. (1986): Kinetics of C-14 furazolidone in piglets upon oral-administration during 10 days and its interaction with tissue macro-molecules. Food Additives and Contaminants, 3, 331-346. Go to original source...
    97. Vroomen L.H., van Bladeren P.J., Groten J.P., Wissink C.J., Kuiper H.A., Berghmans M.C. (1990): In vivo and in vitro metabolic studies of furazolidone: a risk evaluation. Drug Metabolism Reviews, 22, 663-676. Go to original source... Go to PubMed...
    98. Wentzell B., Mccalla D.R. (1980): Formation and excision of nitrofuran-dna adducts in Escherichia-Coli. Chemico-Biological Interactions, 31, 133-150. Go to original source... Go to PubMed...
    99. Wiley M.J., Joneja M.G. (1978): Neural tube lesions in offspring of hamsters given single oral doses of lathyrogens early in gestation. Acta Anatomica, 100, 347- 353. Go to original source... Go to PubMed...
    100. Yoshida K., Kondo F. (1995): Liquid chromatographic determination of furazolidone in swine serum and avian egg. Journal of AOAC International, 78, 1126-1129. Go to original source... Go to PubMed...

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