Vet Med - Czech, 2013, 58(12):621-627 | DOI: 10.17221/7181-VETMED

Diagnostic approach to malignant fibrous histiocytomas of soft tissue in dogs: a case reportCase Report

J.S. Ko1, H.J. Kim1, Y.M. Choi2, J.W. Kim3, C. Park4, S.H. Do1
1 College of Veterinary Medicine and Veterinary Science Research Institute, Konkuk University, Seoul, Republic of Korea
2 Hyundae General Animal Hospital, Seoul, Republic of Korea
3 Kimjunwan Animal Hospital, Bunsan, Republic of Korea
4 Dong-am General Animal Hospital, Incheon, Republic of Korea

Malignant fibrous histiocytomas (MFHs), newly named as 'undifferentiated pleomorphic sarcomas' in 2002 by the World Health Organization, generally show an ambiguous origin. They have been described to fibroblastic or histiocytic in origin, while storiform-pleomorphic variants share a similar morphologic pattern with other sarcomas. For this reason additional diagnostic methods including immunology, ultrastructure analysis and molecular approaches are necessary for a more accurate diagnosis. We report three cases of MFH in individual dogs which presented histological characteristics of pleomorphic sarcomatoid tumours. Microscopic investigation, immunohistochemistry (vimentin, CD68, desmin, α-smooth muscle actin, and S-100) and electron microscopy were performed for diagnosis. One case was diagnosed as storiform-pleomorphic type and two were diagnosed as giant cell type MFHs. The present study demonstrates concepts of MFHs based on newly described categories and suggests useful diagnostic approaches for uncertain sarcomatoid soft tissue tumours in canines.

Keywords: canine; giant cell; malignant fibrous histiocytoma; storiform-pleomorphic; vimentin

Published: December 31, 2013  Show citation

ACS AIP APA ASA Harvard Chicago Chicago Notes IEEE ISO690 MLA NLM Turabian Vancouver
Ko JS, Kim HJ, Choi YM, Kim JW, Park C, Do SH. Diagnostic approach to malignant fibrous histiocytomas of soft tissue in dogs: a case report. Vet Med - Czech. 2013;58(12):621-627. doi: 10.17221/7181-VETMED.
Share...
Download citation
  • BibTeX (.bib)
  • Bookends (.ris)
  • EasyBib (.ris)
  • EndNote (.enw)
  • EndNote 8 (.xml)
  • ISI WoS (.isi)
  • Medlars (.medlars)
  • Mendeley (.ris)
  • MODS (.xml)
  • Papers (.ris)
  • RefWorks (.txt)
  • RefManager (.ris)
  • RIS (.ris)
  • MS Word (.xml)
  • Zotero (.ris)
    • Open full article

    References

    1. Al-Agha OM, Igbokwe AA (2008): Malignant fibrous histiocytoma: between the past and the present. Archives of Pathology and Laboratory Medicine 132, 1030-1035. Go to original source... Go to PubMed...
    2. Andreasen CB, Mahaffey EA (1987): Immunohistochemical demonstration of desmin in canine smooth muscle tumors. Veterinary Pathology 24, 211-215. Go to original source... Go to PubMed...
    3. Cassidy M, Loftus B, Whelan A, Sabt B, Hickey D, Henry K, Leader M (1994): KP-1: not a specific marker. Staining of 137 sarcomas, 48 lymphomas, 28 carcinomas, 7 malignant melanomas and 8 cystosarcoma phyllodes. Virchows Arch 424, 635-640. Go to original source... Go to PubMed...
    4. Christopher DM, Krisjnan U, Fredrik M (2002): Pathology and genetics of tumours of soft tissue and bone: World Health Organization Classification of Tumours. International Agency For Research on Cancer, 109- 126.
    5. Enzinger FM, Weiss SW (eds.) (1995): Soft Tissue Tumors. 3rd ed. Mosby Year Book, St. Louis, Missouri. 139-163.
    6. Fletcher CD (1987): Malignant fibrous histiocytoma? Histopatholgy 11, 433-437. Go to original source... Go to PubMed...
    7. Fletcher CD (1992): Pleomorphic malignant fibrous histiocytoma: fact or fiction? A critical reappraisal based on 159 tumors diagnosed as pleomorphic sarcoma. American Journal of Surgical Pathology 16, 213-228. Go to original source... Go to PubMed...
    8. Hendrick MJ, Brooks JJ, Bruce EH (1992): Six cases of malignant fibrous histiocytoma of the canine spleen. Veterinary Pathology 29, 351-354. Go to original source... Go to PubMed...
    9. Hoffman MA, Dickersin GR (1983): Malignant fibrous histiocytoma: an ultrastructural study of eleven cases. Human Pathology 14, 913-922. Go to original source... Go to PubMed...
    10. Kerlin RL, Hendrick MJ (1996): Malignant fibrous histiocytoma and malignant histiocytosis in the dog - convergent or divergent phenotypic differentiation? Veterinary Pathology 33, 713-716. Go to original source... Go to PubMed...
    11. Kijima Y, Umekita Y, Yoshinaka H, Taguchi S, Owaki T, Funasako Y, Sakamoto A, Yoshida H, Aikou T (2007): Stromal sarcoma with features of giant cell malignant fibrous histiocytoma. Breast Cancer 14, 239-244. Go to original source... Go to PubMed...
    12. Leader M, Patel J, Collins M, Henry K (1987): Anti-alpha 1-antichymotrypsin staining of 194 sarcomas, 38 carcinomas, and 17 malignant melanomas. Its lack of specificity as a tumour marker. American Journal of Surgical Pathology 11, 133-139. Go to original source... Go to PubMed...
    13. Morris JS, McInnes EF, Bostock DE, Hoather TM, Dobson JM (2002): Immunohistochemical and histopathologic features of 14 malignant fibrous histiocytomas from Flat-Coated Retrievers. Veterinary Pathology 39, 473-479. Go to original source... Go to PubMed...
    14. Nonaka D, Chiriboga L, Rubin BP (2008): Differential expression of S100 protein subtypes in malignant melanoma, and benign and malignant peripheral nerve sheath tumors. Journal of Cutaneous Pathology 35, 1014-1019. Go to original source... Go to PubMed...
    15. Ozzello L, Stout AP, Murray MR (1963): Cultural characteristics of malignant histiocytomas and fibrous xanthomas. Cancer 16, 331-344. Go to original source...
    16. Perez J, Bautista MJ, Rollon E, de Lara FC, Carrasco L, Martin de las Mulas J (1996): Immunohistochemical characterization of hemangiopericytomas and other spindle cell tumors in the dog. Veterinary Pathology 33, 391-397. Go to original source... Go to PubMed...
    17. Phui-Ly Liew, Ming-Te Huang, Sey-En Lin, Hsin-An Chen, Chih-Hsiung Wu, Wei-Hwa Lee (2012): Primary hepatic malignant fibrous hisitocytoma mimicking hepatocellular carcinoma: Report of two cases with immunohistochemical detection of Ezirin, and ultrastructural and K-ras Mutation Analysis. Journal of Experimental and Clnical Medicine 4, 183-188. Go to original source...
    18. Schneider P, Busch U, Meister H, Qasem Q, Wünsch PH (1999): Malignant fibrous histiocytoma (MFH). A comparison of MFH in man and animals. A critical review. Histology and Histopathology 14, 845-860. Go to PubMed...
    19. Szollosi Z, Nemeth T, Egervari K, Nemes Z (2005): Histiocyte-like cells expressing factor XIIIa do not belong to the neoplastic cell population in malignant fibrous histiocytoma. Pathology - Research and Practice 201, 369-377. Go to original source... Go to PubMed...
    20. Thomas ME, Koshi R (2013): Electron microscopy in the diagnosis of malignant fibrous histiocytoma of the lung presenting as metastasis to the maxillary gingiva. International Journal of Oral and Maxillofacial Surgery 42, 99-101. Go to original source... Go to PubMed...
    21. Waters CB, Morrison WB, DeNicola DB, Widmer WR, White MR (1994): Giant cell variant of malignant fibrous histiocytoma in dogs: 10 cases (1986-1993). Journal of the American Veterinary Medical Association 205, 1420-1424. Go to PubMed...
    22. Williamson MM, Middleton DJ (1998): Cutaneous soft tissue tumours in dogs: classification, differentiation and histogenesis. Veterinary Dermatology 9, 43-48. Go to original source... Go to PubMed...

    This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International (CC BY NC 4.0), which permits non-comercial use, distribution, and reproduction in any medium, provided the original publication is properly cited. No use, distribution or reproduction is permitted which does not comply with these terms.


    Return to the content