Vet Med - Czech, 2015, 60(7):379-386 | DOI: 10.17221/8386-VETMED

Equine ocular squamous cell carcinoma: a case reportCase Report

M. Drazek1, M. Lew1, S. Lew1, J. Szarek1, I. Balicki2, L. Della Salda3
1 University of Warmia and Mazury, Olsztyn, Poland
2 University of Life Sciences, Lublin, Poland 2Teramo University, Teramo, Italy

An eight-year-old gelding, Wielkopolski Horse was presented with a pink tumour, which filled the entire palpebral fissure of the left eye. Ultrasonography revealed it to be well-demarcated from the cornea mass, which covered its entire surface. Due to the extensive size of the lesion and the lack of owner's consent to post-operative treatment, it was decided to perform enucleation. A histopathological examination revealed corneal squamous cell carcinoma (CSCC). The primary cause of the tumour has not been established. Immunohistochemistry was negative for p16 immunoreactivity which is typical for the E7 oncoprotein in PV infection, and is suspected of involvement in the aetiopathogenesis of ocular squamous cell carcinoma (OSCC).

Keywords: eyeball neoplasm; SCC; p16 protein; horse

Published: July 31, 2015  Show citation

ACS AIP APA ASA Harvard Chicago Chicago Notes IEEE ISO690 MLA NLM Turabian Vancouver
Drazek M, Lew M, Lew S, Szarek J, Balicki I, Della Salda L. Equine ocular squamous cell carcinoma: a case report. Vet Med - Czech. 2015;60(7):379-386. doi: 10.17221/8386-VETMED.
Share...
Download citation
  • BibTeX (.bib)
  • Bookends (.ris)
  • EasyBib (.ris)
  • EndNote (.enw)
  • EndNote 8 (.xml)
  • ISI WoS (.isi)
  • Medlars (.medlars)
  • Mendeley (.ris)
  • MODS (.xml)
  • Papers (.ris)
  • RefWorks (.txt)
  • RefManager (.ris)
  • RIS (.ris)
  • MS Word (.xml)
  • Zotero (.ris)
    • Open full article

    References

    1. Albanese V, Hanson R, McMaster M, Underwood K, Caldwell F (2014): Radical eye exenteration and second intention healing in horses: A case series. Journal of Equine Veterinary Science 34, 1342-1347. Go to original source...
    2. Albaric O, Bret L, Amardeihl M, Delverdier M (2001): Immunohistochemical expression of p53 in animal tumors: a methodological study using four anti-human p53 antibodies. Histology and Histopathology 16, 113-121. Go to PubMed...
    3. Auw-Haedrich C, Martin G, Spelsberg H, Sundmacher R, Freudenberg N, Maier P, Reinhard T (2008): Expression of p16 in conjunctival intraepithelial neoplasia does not correlate with HPV infection. The Open Ophthalmology Journal 2, 48-56. Go to original source... Go to PubMed...
    4. Beard WL, Wilkie DA (2002): Partial orbital rim resection, mesh skin expansion, and second intention healing combined with enucleation or exenteration for extensive periocular tumors in horses. Veterinary Ophthalmology 5, 23-28. Go to original source... Go to PubMed...
    5. Bosh G, Klein WR (2005): Superficial keratectomy and cryosurgery as therapy for limbal neoplasms in 13 horses. Veterinary Ophthalmology 8, 241-246. Go to original source... Go to PubMed...
    6. Brash DE, Rudolph JA, Simon JA, Lin A, McKenna GJ, Baden HP, Halperin AJ, Ponten J (1991): A role for sunlight in skin cancer: UV-induced p53 mutations in squamous cell carcinoma. Proceedings of the National Academy of Sciences 88, 10124-10128. Go to original source... Go to PubMed...
    7. Carvalho T, Vala H, Pinto C, Pinho M, Peleteiro MC (2005): Immunohistochemical studies of epithelial cell proliferation and p53 mutation in bovine ocular squamous cell carcinoma. Veterinary Pathology 42, 66-73. Go to original source... Go to PubMed...
    8. Chahory S, Clerc B, Devauchelle P, Tnibar A (2002): Treatment of a recurrent ocular squamous cell carcinoma in a horse with iridium-192 implantation. Journal of Equine Veterinary Science 22, 503-506. Go to original source...
    9. Chauhan S, Sen S, Sharma A, Dar L, Kashyap S, Kumar P, Bajaj MS, Tandon R (2012): Human papillomavirus: a predictor of better survival in ocular surface squamous neoplasia patients. British Journal of Ophthalmology 96, 1517-1521. Go to original source... Go to PubMed...
    10. Clode AB, Miller C, McMullen RJ Jr, Gilger BC (2012): A retrospective comparison of surgical removal and subsequent CO2 laser ablation versus topical administration of mitomycin C as therapy for equine corneolimbal squamous cell carcinoma. Veterinary Ophthalmology 15, 254-262. Go to original source... Go to PubMed...
    11. Dubielzig RR (2002): 15 Tumors of the eye. In: Meuten DJ (ed.):Tumors in Domestic Animals. 4th ed. Wiley-Blackwell, Ames, Iowa. 739-754. Go to original source...
    12. Dugan SJ, Curtis CR, Roberts SM, Severin GA (1991a): Epidemiologic study of ocular/adnexal squamous cell carcinoma in horses. Journal of the American Veterinary Medical Association 198, 251-256. Go to original source... Go to PubMed...
    13. Dugan SJ, Roberts SM, Curtis CR, Severin GA (1991b): Prognostic factors and survival of horses with ocular/ adnexal squamous cell carcinoma: 147 cases (1978-1988). Journal of the American Veterinary Medical Association 198, 298-303. Go to original source... Go to PubMed...
    14. English RV, Nasisse MP, Davidson MG (1990): Carbon dioxide laser ablation for treatment of limbal squamous cell carcinoma in horses. Journal of the American Veterinary Medical Association 196, 439-442. Go to original source... Go to PubMed...
    15. Eversole TG, Lavach JD (1978): Primary ocular squamous cell carcinoma with metastasis in a horse. Veterinary Medicine and Small Animal Clinician 73, 287-288.
    16. Gelatt KN (1975): Corneolimbal squamous cell carcinoma in the horse. Veterinary Medicine and Small Animal Clinician 50, 53.
    17. Gelatt KN, Myers VS Jr, Perman V, Jessen C (1974): Conjunctival squamous cell carcinoma in the horse. Journal of the American Veterinary Medical Association 165, 617-620. Go to PubMed...
    18. Gilger BC (2013): 28 Equine Ophthalmology. In: Gelatt KN, Gilger BC, Kern TJ (eds.): Veterinary Ophthalmology, 5th ed. Wiley-Blackwell, Ames, Iowa. 1560-1610.
    19. Gilger BC, Davidson MG (2002): How to prepare for ocular surgery in the standing horse. Proceedings of American Association of Equine Practitioners 48, 266-271.
    20. Giuliano EA, MacDonald I, McCaw DL, Dougherty TJ, Klauss G, Ota J, Pearce JW, Johnson PJ (2008): Photodynamic therapy for the treatment of periocular squamous cell carcinoma in horses: a pilot study. Veterinary Ophthalmology 11, 27-34. Go to original source... Go to PubMed...
    21. Gonzalez-Alonso-Alegre EM, Rodriguez-Alvaro A, Martinez-Nevado E, Martinez-de-Merlo EM, Sanchez-Maldonado B (2013): Conjunctival squamous cell carcinoma in a reindeer (Rangifer tarandus tarandus). Veterinary Ophthalmology 16, 113-116. Go to original source... Go to PubMed...
    22. Hacker DV, Moore PF, Buyukmihci NC (1986): Ocular angiosarcoma in four horses. Journal of the American Veterinary Medical Association 189, 200-203. Go to PubMed...
    23. Hall PA, McKee PH, Menage HD, Dover R, Lane DP (1993): High levels of p53 protein in UV-irradiated normal human skin. Oncogene 8, 203-207. Go to PubMed...
    24. Kafarnik C, Rawlings M, Dubielzig RR (2009): Corneal stromal invasive squamous cell carcinoma: a retrospective morphological description in 10 horses. Veterinary Ophthalmology 12, 6-12. Go to original source... Go to PubMed...
    25. Kamb A (1994): Cancer. Sun protection factor p53. Nature 372, 730-731. Go to original source... Go to PubMed...
    26. Kaps S, Richter M, Philipp M, Bart M, Eule C, Spiess BM (2005): Primary invasive ocular squamous cell carcinoma in a horse. Veterinary Ophthalmology 8, 193-197. Go to original source... Go to PubMed...
    27. Kim DY, Cho HS, Schommer S, Giuliano EA, Johnson PJ (2009): A novel equine papillomavirus as a possible etiology of equine ocular squamous cell carcinoma. Veterinary Pathology 46, 1074.
    28. King TC, Priehs DR, Gum GG, Miller TR (1991): Therapeutic management of ocular squamous cell carcinoma in the horse: 43 cases (1979-1989). Equine Veterinary Journal 23, 449-452. Go to original source... Go to PubMed...
    29. Koch SA, Cowles RR Jr (1971): Surgical removal of a squamous cell carcinoma of the equine eye. Veterinary Medicine and Small Animal Clinician 66, 327-329.
    30. Konig F, Krekeler G, Honig JF, Cordon-Cardo C, Fischer G, Korabiowska M (2007): Relation between human papillomavirus positivity and p16 expression in head and neck carcinomas-a tissue microarray study. Anticancer Research 27, 283-288.
    31. Lane DP (1992): Cancer. p53, guardian of the genome. Nature 358, 15-16. Go to original source... Go to PubMed...
    32. Lassaline M, Cranford TL, Latimer CA, Bellone RR (2014): Limbal squamous cell carcinoma in Haflinger horses. Veterinary Ophthalmology. Oct 14. doi: 10.1111/vop.12229. Go to original source... Go to PubMed...
    33. Lavach JD (1990): Ocular neoplasia. In: Lavach JD (ed.): Large Animal Ophthalmology, 1st ed. Mosby, London. 270-288.
    34. Lavach JD, Severin GA (1977): Neoplasia of the equine eye, adnexa, and orbit: a review of 68 cases. Journal of the American Veterinary Medical Association 170, 202-203. Go to PubMed...
    35. Mair TS, Sherlock CE, Pearson GR (2012): Delayed metastasis of ocular squamous cell carcinoma following treatment in five horses. Equine Veterinary Education, doi: 10.1111/j.2042-3292.2012.00435.x Go to original source...
    36. Malalana F, Knottenbelt D, McKane S (2010): Mitomycin C, with or without surgery, for the treatment of ocular squamous cell carcinoma in horses. Veterinary Record 167, 373-376. Go to original source... Go to PubMed...
    37. McCalla TL, Moore CP, Collier LL (1992): Immunotherapy of periocular squamous cell carcinoma with metastasis in a pony. Journal of the American Veterinary Medical Association 200, 1678-1681. Go to original source... Go to PubMed...
    38. Michau TM, Davidson MG, Gilger BC (2012): Carbon dioxide laser photoablation adjunctive therapy following superficial lamellar keratectomy and bulbar conjunctivectomy for the treatment of corneolimbal squamous cell carcinoma in horses: a review of 24 cases. Veterinary Ophthalmology 15, 245-253. Go to original source... Go to PubMed...
    39. Monlux AW, Anderson WA, Davis CL (1957): The diagnosis of squamous cell carcinoma of the eye (cancer eye) in the cattle. American Journal of Veterinary Research 18, 5-34.
    40. Mosunic CB, Moore PA, Carmicheal KP, Chandler MJ, Vidyashankar A, Zhao Y, Roberts RE, Dietrich UM (2004): Effects of treatment with and without adjuvant radiation therapy on recurrence of ocular and adnexal squamous cell carcinoma in horses: 157 cases (1985-2002). Journal of the American Veterinary Medical Association 225, 1733-1738. Go to original source... Go to PubMed...
    41. Munday JS, French AF, Peters-Kennedy J, Orbell GM, Gwynne K (2011a): Increased p16CDKN2A protein within feline cutaneous viral plaques, bowenoid in situ carcinomas, and a subset of invasive squamous cell carcinomas. Veterinary Pathology 48, 460-465. Go to original source... Go to PubMed...
    42. Munday JS, Knight CG, French AF (2011b): Evaluation of feline oral squamous cell carcinomas for p16CDKN2A protein immunoreactivity and the presence of papillomaviral DNA. Research in Veterinary Science 90, 280-283. Go to original source... Go to PubMed...
    43. Munday JS, Fairley RA, Mills H, Kiupel M, Vaatstra BL (2015): Oral Papillomas Associated With Felis catus Papillomavirus Type 1 in 2 Domestic Cats. Veterinary Pathology, pii: 0300985814565133
    44. Nasir L, Brandt S (2013): Papillomavirus associated diseases of the horse. Veterinary Microbiology 167, 159-167. Go to original source... Go to PubMed...
    45. Payne RJ, Lean MS, Greet TR (2009): Third eyelid resection as a treatment for suspected squamous cell carcinoma in 24 horses. Veterinary Record 165, 740-743.
    46. Pierce KE Jr, Townsend WM (2012): 55 Surgery of the Globe and Orbit. In: Auer JA, Stick JA (eds.): Equine Surgery. 4th ed. Saunders. 728-743. Go to original source...
    47. Plummer CE, Smith S, Andrew SE, Lassaline ME, Gelatt KN, Brooks DE, Kallberg ME, Ollivier FJ (2007): Combined keratectomy, strontium-90 irradiation and permanent bulbar conjunctival grafts for corneolimbal squamous cell carcinomas in horses (1990-2002): 38 horses. Veterinary Ophthalmology 10, 37-42. Go to original source... Go to PubMed...
    48. Pucket JD, Gilmour MA (2014): Intralesional 5-fluorouracil (5-FU) for the treatment of eyelid squamous cell carcinoma in 5 horses. Equine Veterinary Education 26, 331-335 Go to original source...
    49. Ramadan RO (1975): Primary ocular melanoma in a young horse. Equine Veterinary Journal 7, 49-50. Go to original source... Go to PubMed...
    50. Rebhun WC (1990): Treatment of advanced squamous cell carcinomas involving the equine cornea. Veterinary Surgery 19, 297-302. Go to original source... Go to PubMed...
    51. Schnoke AT, Brooks DE, Wilkie DA, Dwyer AE, Matthews AG, Gilger BC, Hendrix DV, Pickett P, Grauwels M, Monroe C, Plummer CE (2013): Extraocular lymphoma in the horse. Veterinary Ophthalmology 16, 35-42. Go to original source...
    52. Schoster JV (1992): Using combined excision and cryotherapy to treat limbal squamous cell carcinoma. Veterinary Medicine 87, 357-365.
    53. Schwink K (1987): Factors influencing morbidity and outcome of equine ocular squamous cell carcinoma. Equine Veterinary Journal 19, 198-200. Go to original source... Go to PubMed...
    54. Scurrell EJ, Lewin G, Solomons M, Rozmanec M, Belford CJ (2013): Corneolimbal squamous cell carcinoma with intraocular invasion in two cats. Veterinary Ophthalmology 16, 151-154. Go to original source... Go to PubMed...
    55. Sironi G, Riccaboni P, Mertel L, Cammarata G, Brooks DE (1999): p53 protein expression in conjunctival squamous cell carcinomas of domestic animals. Veterinary Ophthalmology 2, 227-231. Go to original source... Go to PubMed...
    56. Takiyama N, Terasaki E, Uechi M (2010): Corneal squamous cell carcinoma in two dogs. Veterinary Ophthalmology 13, 266-269. Go to original source... Go to PubMed...
    57. Teifke JP, Lohr CV (1996): Immunohistochemical detection of P53 overexpression in paraffin wax-embedded squamous cell carcinomas of cattle, horses, cats and dogs. Journal of Comparative Pathology 114, 205-210. Go to original source... Go to PubMed...
    58. Theon AP, Pascoe JR (1995): Iridium-192 interstitial brachytherapy for equine periocular tumours: treatment results and prognostic factors in 115 horses. Equine Veterinary Journal 27, 117-121. Go to original source... Go to PubMed...
    59. Theon AP, Pascoe JR, Carlson GP, Krag DN (1993): Intratumoral chemotherapy with cisplatin in oily emulsion in horses. Journal of the American Veterinary Medical Association 202, 261-267. Go to original source... Go to PubMed...
    60. Theon AP, Pascoe JR, Galuppo LD, Fisher PE, Griffey SM, Madigan JE (1999): Comparison of perioperative versus postoperative intratumoral administration of cisplatin for treatment of cutaneous sarcoids and squamous cell carcinomas in horses. Journal of the American Veterinary Medical Association 215, 1655-1660. Go to original source... Go to PubMed...
    61. van der Woerdt A, Gilger BC, Wilkie DA (1996): Penetrating keratoplasty for treatment of recurrent squamous cell carcinoma of the cornea in a horse. Journal of the American Veterinary Medical Association 15, 1692-1694. Go to original source...
    62. Walker MA, Goble D, Geiser DR (1986): Two-year nonrecurrence rates for equine ocular and periorbital squamous cell carcinoma following radiotherapy. Veterinary Radiology 27, 146-148. Go to original source...
    63. Wilkie DA, Burt JK (1990): Combined treatment of ocular squamous cell carcinoma in a horse, using radiofrequency hyperthermia and interstitial 198Au implants. Journal of the American Veterinary Medical Association 196, 1831-1833. Go to original source... Go to PubMed...
    64. Woods M, Chow S, Heng B, Glenn W, Whitaker N, Waring D, Iwasenko J, Rawlinson W, Coroneo MT, Wakefield D, Di Girolamo N (2013): Detecting human papillomavirus in ocular surface diseases. Investigative Ophthalmology and Visual Science 54, 8069-8078. Go to original source... Go to PubMed...

    This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International (CC BY NC 4.0), which permits non-comercial use, distribution, and reproduction in any medium, provided the original publication is properly cited. No use, distribution or reproduction is permitted which does not comply with these terms.


    Return to the content