Vet Med - Czech, 2019, 64(10):462-466 | DOI: 10.17221/46/2019-VETMED

Improvement of systemic lupus erythematosus in dogs with canine adipose-derived stem cellsCase Report

Minho Ko1, Tae Hyeong Kim2, Yoonhwan Kim1, Doo Kim1, Jin-Ok Ahn1, Byung-Jae Kang3, Sooyoung Choi4, Inchul Park4, Jung Hoon Choi2, Jin Young Chung*,1
1 Department of Veterinary Internal Medicine and Institute of Veterinary Science, College of Veterinary Medicine, Kangwon National University, Chuncheon-si, Gangwon-do, Republic of Korea
2 Department of Veterinary Anatomy, College of Veterinary Medicine, Kangwon National University, Chuncheon-si, Gangwon-do, Republic of Korea
3 Department of Veterinary Surgery, College of Veterinary Medicine, Kangwon National University, Chuncheon-si, Gangwon-do, Republic of Korea
4 Department of Veterinary Diagnostic Imaging, College of Veterinary Medicine, Kangwon National University, Gangwondo, Republic of Korea

A 6-year-old, intact female, Maltese presented with limited movement of the hind limbs and intermittent pruritus for three months. The patient was diagnosed with systemic lupus erythematosus. Conventional immunosuppressive therapy was attempted for 70 days; however, the patient still suffered from life-threatening pancreatitis and hepatopathy. Therefore, we tried canine adipose-derived mesenchymal stem cells for immunomodulation and liver protection. After 6-months of the stem cell therapy, the patient's walking and hepatopathy improved. These findings indicate that stem cell therapy may be another option for systemic lupus erythematosus in dogs.

Keywords: dog; SLE; stem cell therapy

Published: October 31, 2019  Show citation

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Ko M, Kim TH, Kim Y, Kim D, Ahn J, Kang B, et al.. Improvement of systemic lupus erythematosus in dogs with canine adipose-derived stem cells. Vet Med - Czech. 2019;64(10):462-466. doi: 10.17221/46/2019-VETMED.
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