Vet Med - Czech, 2020, 65(5):221-226 | DOI: 10.17221/13/2020-VETMED

Diagnostic imaging of a mass-shape hepatic steatosis in a dog treated with chemotherapyCase Report

N Lee ORCID...1,2, J Seo2, J Kim2, J Yoon1
1 College of Veterinary Medicine and the Research Institute for Veterinary Science, Seoul National University, Gwanak-ro, Gwanak-gu, Seoul, Republic of Korea
2 Time Animal Medical Center, Dunsan-ro, Seo-gu, Daejeon, Republic of Korea

A left medial liver mass was found through the monitoring of the metastasis in a 15-years-old, spayed female Maltese dog. The patient had a history of chemotherapy with carboplatin after surgical resection of the mammary gland tumour. Ultrasonography (US) showed a massive hyperechoic mass in the left liver. The left medial liver mass was identified as a poorly demarcated, hypoattenuated area on the non-enhanced and all the phases of contrast-enhanced computed tomography. The liver mass was surgically removed and the histopathological examination showed a fatty deposition and no evidence of neoplasm. Based on the patient's history, diagnostic imaging and histopathological findings, the liver mass was considered as a chemotherapy-induced hepatic steatosis. This report provides the diagnostic imaging characteristics of the hepatic steatosis that could help differentiate it from a malignancy in a dog treated with chemotherapy.

Keywords: chemotherapy; diagnostic imaging; dog; hepatic steatosis; mass shaped

Received: January 20, 2020; Accepted: March 23, 2020; Published: May 31, 2020  Show citation

ACS AIP APA ASA Harvard Chicago Chicago Notes IEEE ISO690 MLA NLM Turabian Vancouver
Lee N, Seo J, Kim J, Yoon J. Diagnostic imaging of a mass-shape hepatic steatosis in a dog treated with chemotherapy. Vet Med - Czech. 2020;65(5):221-226. doi: 10.17221/13/2020-VETMED.
Share...
Download citation
  • BibTeX (.bib)
  • Bookends (.ris)
  • EasyBib (.ris)
  • EndNote (.enw)
  • EndNote 8 (.xml)
  • ISI WoS (.isi)
  • Medlars (.medlars)
  • Mendeley (.ris)
  • MODS (.xml)
  • Papers (.ris)
  • RefWorks (.txt)
  • RefManager (.ris)
  • RIS (.ris)
  • MS Word (.xml)
  • Zotero (.ris)
    • Open full article

    References

    1. Brown DL, Van Wettere AJ, Cullen JM. Hepatobiliary system and exocrine pancreas. In: Zachary JF, editor. Pathologic basis of veterinary disease. St Louis, Missouri, USA: Elsevier; 2017. p. 438-9. Go to original source...
    2. Carloni A, Paninarova M, Cavina D, Romanucci M, Salda LD, Teodori S, Vignoli M. Negative hepatic computed tomographic attenuation pattern in a dog with vacuolar hepatopathy and hepatic fat accumulation secondary to cushing's syndrome. Vet Radiol Ultrasound. 2019 Sep; 60(5):E54-E7. Go to original source... Go to PubMed...
    3. Cullen JM, Stalker MJ. Liver and biliary system. In: Grant Maxie M, editor. Jubb, Kennedy, and Palmer's pathology of domestic animals. St Louis, Missouri, USA: Elsevier; 2016. p. 273-6.
    4. Day CP. Genes or environment to determine alcoholic liver disease and non-alcoholic fatty liver disease. Liver Int. 2006 Nov;26(9):1021-8. Go to original source... Go to PubMed...
    5. Decarie PO, Lepanto L, Billiard JS, Olivie D, Murphy-Lavallee J, Kauffmann C, Tang A. Fatty liver deposition and sparing: A pictorial review. Insights Imaging. 2011 Oct; 2(5):533-8. Go to original source... Go to PubMed...
    6. Gaschen L. Update on hepatobiliary imaging. Vet Clin Small Anim. 2009 May 1;39(3):439-67. Go to original source... Go to PubMed...
    7. Hamer OW, Aguirre DA, Casola G, Lavine JE, Woenckhaus M, Sirlin CB. Fatty liver: Imaging patterns and pitfalls. Radiographics. 2006 Nov-Dec;26(6):1637-53. Go to original source... Go to PubMed...
    8. Heo SH, Yoon YM, Hwang TS, Jung DI, Lee HC. Imaging diagnosis of hepatic lipidosis in a cat. Korean J Vet Res. 2018 Jun 1;58(2):99-101. Go to original source...
    9. Hume KR, Johnson JL, Williams LE. Adverse effects of concurrent carboplatin chemotherapy and radiation therapy in dogs. J Vet Intern Med. 2009 Jan-Feb;23(1):24-30. Go to original source... Go to PubMed...
    10. Hunt GB, Luff JA, Daniel L, Van den Bergh R. Evaluation of hepatic steatosis in dogs with congenital portosystemic shunts using Oil-Red-O staining. Vet Pathol. 2013 Nov; 50(6):1109-15. Go to original source... Go to PubMed...
    11. Jain KA, McGahan JP. Spectrum of CT and sonographic appearance of fatty infiltration of the liver. Clin Imaging. 1993 Apr-Jun;17(2):162-8. Go to original source... Go to PubMed...
    12. Kalil AN, Coral GP, Santos FA, Gonzalez MC, Neutzling CB. The association between preoperative chemotherapy and the prevalence of hepatic steatosis in hepatectomy for metastatic colorectal cancer. Arq Bras Cir Dig. 2014 Apr-Jun;27(2):120-5. Go to original source... Go to PubMed...
    13. King PD, Perry MC. Hepatotoxicity of chemotherapy. Oncologist. 2001;6(2):162-76. Go to original source... Go to PubMed...
    14. Maor Y, Malnick S. Liver injury induced by anticancer chemotherapy and radiation therapy. Int J Hepatol. 2013;2013: 815105. Go to original source... Go to PubMed...
    15. Oun R, Moussa YE, Wheate NJ. The side effects of platinum-base chemotherapy drugs: A review for chemists. Dalton Trans. 2018 May 15;47(19):6645-53. Go to original source... Go to PubMed...
    16. Rabinowich L, Shibolet O. Drug induced steatohepatitis: An uncommon culprit of a common disease. Biomed Res Int. 2015;2015:168905. Go to original source... Go to PubMed...
    17. Reddy SK, Reilly C, Zhan M, Mindikoglu AL, Jiang Y, Lane BF, Alexander HR, Culpepper WJ, El-Kamary SS. Longterm influence of chemotherapy on steatosis-associated advanced hepatic fibrosis. Med Oncol. 2014 Jun;31 (6):971. Go to original source... Go to PubMed...
    18. Sharma A, Houshyar R, Bhosale P, Choi JI, Gulati R, Lall C. Chemotherapy induced liver abnormalities: an imaging perspective. Clin Mol Hepatol. 2014 Sep;20(3):317-26. Go to original source... Go to PubMed...
    19. Van den Bossche L, Schoonenberg VAC, Burgener IA, Penning LC, Schrall IM, Kruitwagen HS, van Wolferen ME, Grinwis GCM, Kummeling A, Rothuizen J, van Velzen JF, Stathonikos N, Molenaar MR, Helms BJ, Brouwers JFHM, Spee B, van Steenbeek FG. Aberrant hepatic lipid storage and metabolism in canine portosystemic shunts. PLoS One. 2017 Oct 19;12(10):e0186491. Go to original source... Go to PubMed...
    20. Van Winkle T, Cullen JM, Van den lngh TSGAM, Charles JA, Desmet VJ. Morphologic classification of parenchymal disorders of the canine and feline liver. In: WSAVA liver standardization group. Standards for clinical and histopathological diagnosis of canine and feline liver disease. St Louis, Missouri, USA: Elsevier; 2006. p. 79-81.
    21. Vilgrain V, Ronot M, Abdel-Rehim M, Zappa M, d'Assignies G, Bruno O, Vullierme MP. Hepatic steatosis: A major trap in liver imaging. Diagn Interv Imaging. 2013 JulAug;94(7-8):713-27. Go to original source... Go to PubMed...
    22. Yeh MM, Brunt EM. Pathological features of fatty liver disease. Gastroenterology. 2014 Oct;147(4):754-64. Go to original source... Go to PubMed...
    23. You SH, Park BJ, Kim YH. Hepatic lesions that mimic metastasis on radiological imaging during chemotherapy for gastrointestinal malignancy: Recent updates. Korean J Radiol. 2017 May-Jun;18(3):413-26. Go to original source... Go to PubMed...

    This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International (CC BY NC 4.0), which permits non-comercial use, distribution, and reproduction in any medium, provided the original publication is properly cited. No use, distribution or reproduction is permitted which does not comply with these terms.


    Return to the content